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公开(公告)号:US12274699B2
公开(公告)日:2025-04-15
申请号:US18346029
申请日:2023-06-30
Applicant: Foundation Medicine, Inc.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , A61K31/19 , A61K31/404 , A61K31/435 , A61K31/4412 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/5383 , A61K31/553 , A61K45/06 , C07K14/705 , C07K14/71 , C07K16/40 , C12N9/12 , C12N15/113 , C12Q1/6883 , C12Q1/6886 , G01N33/573
Abstract: Methods and compositions for treating cholangiocarcinoma.
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公开(公告)号:US20180280391A1
公开(公告)日:2018-10-04
申请号:US15839560
申请日:2017-12-12
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , C12N15/113 , A61K31/513 , C07K14/82 , A61K31/4412 , A61K31/404 , A61K31/47 , C12Q1/6886 , C12N9/14 , A61K31/444
Abstract: Novel RET fusion molecules and uses are disclosed.
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公开(公告)号:US09861633B2
公开(公告)日:2018-01-09
申请号:US14333368
申请日:2014-07-16
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jeffrey S. Ross , Philip James Stephens
IPC: C12Q1/68 , A61K31/517 , A61K47/48 , A61K31/5365 , C07K14/82 , C07K16/32 , A61K45/06 , A61K31/475 , A61K31/519 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24
CPC classification number: A61K31/517 , A61K31/475 , A61K31/519 , A61K31/5365 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , C07K14/82 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , A61K2300/00
Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
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公开(公告)号:US20140037622A1
公开(公告)日:2014-02-06
申请号:US13958502
申请日:2013-08-02
Applicant: UCL Business PLC , FOUNDATION MEDICINE, INC.
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Roman Yelensky , Garrett Michael Frampton
IPC: C12Q1/70 , A61K31/519 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/506
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
Abstract translation: 公开了治疗头颈癌的方法。
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公开(公告)号:US11771698B2
公开(公告)日:2023-10-03
申请号:US17204830
申请日:2021-03-17
Applicant: Foundation Medicine, Inc.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , A61K31/498 , A61K31/19 , A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/496 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
CPC classification number: A61K31/5025 , A61K31/404 , A61K31/435 , A61K31/4412 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5383 , A61K31/553 , A61K45/06 , C07K14/705 , C07K14/71 , C07K16/40 , C12N9/12 , C12N15/1137 , C12Q1/6883 , C12Q1/6886 , C12Y207/10001 , G01N33/573 , C07K2319/00 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Q2600/156 , C12Q2600/158 , G01N2333/912 , G01N2500/04
Abstract: Methods and compositions for treating cholangiocarcinoma.
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公开(公告)号:US11766439B2
公开(公告)日:2023-09-26
申请号:US17344777
申请日:2021-06-10
Applicant: FOUNDATION MEDICINE, INC. , UCL BUSINESS LTD
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/55 , A61K38/00 , A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/505 , A61K31/555 , A61K33/243 , A61K33/24 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10 , A61K39/00
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K33/243 , A61K39/39558 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , G01N33/571 , A61K2039/505 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , A61K31/404 , A61K2300/00 , A61K31/454 , A61K2300/00 , A61K31/506 , A61K2300/00 , A61K31/513 , A61K2300/00 , A61K31/519 , A61K2300/00 , A61K31/52 , A61K2300/00 , A61K33/24 , A61K2300/00 , A61K31/436 , A61K2300/00 , A61K31/05 , A61K2300/00 , A61K31/366 , A61K2300/00 , A61K31/505 , A61K2300/00 , A61K31/555 , A61K2300/00 , A61K31/337 , A61K2300/00 , A61K31/282 , A61K2300/00 , A61K31/4196 , A61K2300/00 , A61K31/4709 , A61K2300/00 , A61K31/496 , A61K2300/00 , A61K31/5377 , A61K2300/00 , A61K31/105 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US11450438B2
公开(公告)日:2022-09-20
申请号:US16579496
申请日:2019-09-23
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
Abstract: A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.
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公开(公告)号:US20180338977A1
公开(公告)日:2018-11-29
申请号:US15873703
申请日:2018-01-17
Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/6886 , A61K31/496 , A61K31/4709 , A61K31/05 , A61K31/436 , A61K39/395 , A61K31/513 , A61K31/337 , A61K31/282 , A61K33/24 , A61K31/4196 , A61K31/404 , A61K31/52 , A61K31/454 , A61K31/506 , C12Q1/70 , A61N5/00 , A61K31/352 , A61N5/10 , G01N33/571 , A61K31/439 , A61K31/4745
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US20170014413A1
公开(公告)日:2017-01-19
申请号:US15045716
申请日:2016-02-17
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , A61K31/47 , A61K31/513 , A61K31/4412 , A61K31/404
CPC classification number: A61K31/517 , A61K31/404 , A61K31/4412 , A61K31/444 , A61K31/47 , A61K31/513 , C07K14/82 , C07K2319/00 , C12N9/14 , C12N15/1135 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
Abstract: Novel RET fusion molecules and uses are disclosed. In one embodiment, a KIF5B-RET fusion includes an in-frame fusion of an exon of KIF5B (e.g., one or more exons encoding a kinesin motor domain or a fragment thereof) and an exon of RET (e.g., one or more exons encoding a RET tyrosine kinase domain or a fragment thereof). For example, the KIF5B-RET fusion can include an in-frame fusion of at least exon 15 of KIF5B or a fragment thereof (e.g., exons 1-15 of KIF5B or a fragment thereof) with at least exon 12 of RET or a fragment thereof (e.g., exons 12-20 of RET or a fragment thereof).
Abstract translation: 公开了新型RET融合分子和用途。 在一个实施方案中,KIF5B-RET融合包括KIF5B的外显子(例如,编码驱动蛋白运动区或其片段的一个或多个外显子)和RET的外显子(例如,一个或多个外显子编码 RET酪氨酸激酶结构域或其片段)。 例如,KIF5B-RET融合可以包括至少外显子15的KIF5B或其片段(例如,KIF5B的外显子1-15或其片段)与至少外显子12的RET或片段的片段内融合 (例如,RET的外显子12-20或其片段)。
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公开(公告)号:US20160375025A1
公开(公告)日:2016-12-29
申请号:US15200088
申请日:2016-07-01
Applicant: FOUNDATION MEDICINE, INC. , UCL Business PLC
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/68 , A61N5/10 , A61K31/506
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
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