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公开(公告)号：USD797887S1
公开(公告)日：2017-09-19
申请号：US29562478
申请日：2016-04-26
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公开(公告)号：US20170217794A1
公开(公告)日：2017-08-03
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, JR. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
CPC分类号： C02F1/36 , B01D17/04 , B01D17/041 , B01D17/044 , B01D19/0078 , B01D21/28 , B06B1/0622 , B06B1/0644 , C02F1/40 , C12M35/04 , C12M47/02 , C12N1/02 , C12N13/00 , G10K11/28 , H01L41/0913
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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公开(公告)号：US09512395B2
公开(公告)日：2016-12-06
申请号：US14533753
申请日：2014-11-05
发明人： Bart Lipkens , Jason Barnes , Dane Mealey , Walter M. Presz, Jr. , Stanley Kowalski, III , Louis Masi , Thomas J. Kennedy, III , Brian McCarthy , Ben Ross-Johnsrud
CPC分类号： C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
摘要： An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
摘要翻译： 公开了一种由模块化部件组成的消声器。 本文公开了多个模块，包括超声换能器模块，输入/输出模块，收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒（例如生物细胞）的适当流体动力学的不同系统。
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公开(公告)号：US10814253B2
公开(公告)日：2020-10-27
申请号：US15690263
申请日：2017-08-29
发明人： Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
摘要： Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号：US20200215109A1
公开(公告)日：2020-07-09
申请号：US16244100
申请日：2019-01-09
发明人： Bart Lipkens , Rui Tostoes , Walter M. Presz, JR. , Benjamin Ross-Johnsrud , Kedar Chitale , Thomas J. Kennedy, III , Brian Dutra , Brian McCarthy , Jack Saloio
摘要： A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
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公开(公告)号：US09744483B2
公开(公告)日：2017-08-29
申请号：US15249129
申请日：2016-08-26
发明人： Bart Lipkens , Walter M. Presz, Jr. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
CPC分类号： B01D21/283 , B01D21/0042 , B01D21/0045 , B01D21/0087 , B01D21/2422 , B06B1/06 , C02F1/36 , C12M47/02
摘要： Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号：US20150209695A1
公开(公告)日：2015-07-30
申请号：US14678841
申请日：2015-04-03
发明人： Brian McCarthy , Ben Ross-Johnsrud , Bart Lipkens
CPC分类号： B01D21/28 , B01D17/04 , B01D17/044 , B01J19/10 , B01J2219/0869 , B06B1/0644 , C12M35/04 , C12M47/02
摘要： An apparatus includes a flow chamber having at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber, which operates to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer. The reflector is formed from a thin structure that provides a pressure release boundary, such as a plastic film/air interface.
摘要翻译： 一种装置包括具有至少一个入口和至少一个出口的流动室。 至少一个超声波换能器位于流动室的壁上，其操作以在流动室中产生多维声驻波。 反射器位于流动室的与至少一个超声换能器相反的一侧的壁上。 反射器由提供压力释放边界的薄结构形成，例如塑料膜/空气界面。
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公开(公告)号：US10975368B2
公开(公告)日：2021-04-13
申请号：US15672288
申请日：2017-08-08
发明人： Bart Lipkens , Brian McCarthy , Ben Ross-Johnsrud , Jason Barnes , Dane Mealey , Thomas J. Kennedy, III
摘要： An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
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公开(公告)号：US10322949B2
公开(公告)日：2019-06-18
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, Jr. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
IPC分类号： C02F1/36 , B06B1/06 , B01D17/04 , C02F1/40 , B01D19/00 , B01D21/28 , C12M1/42 , G10K11/28 , C12N1/02 , C12N13/00 , C12M1/00 , H01L41/09
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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公开(公告)号：US20180015392A1
公开(公告)日：2018-01-18
申请号：US15690263
申请日：2017-08-29
发明人： Bart Lipkens , Walter M. Presz, JR. , Jeffrey King , Jason Barnes , Dane Mealey , Brian McCarthy , Ben Ross-Johnsrud , Kedar Chitale
摘要： Devices for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a concentrate outlet at a bottom end of the acoustic chamber, and an inlet on a first side end of the acoustic chamber. An ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the acoustic chamber that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet, and the particulates are collected via the concentrate outlet. The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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