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公开(公告)号：US11459540B2
公开(公告)日：2022-10-04
申请号：US15983823
申请日：2018-05-18
发明人： Rui Tostoes , Bart Lipkens , Kedar Chitale , Benjamin Ross-Johnsrud , Walter M. Presz, Jr. , Jack Saloio
摘要： Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.
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公开(公告)号：US20210277381A1
公开(公告)日：2021-09-09
申请号：US17323868
申请日：2021-05-18
摘要： Methods and systems for processing material in a host fluid use an acoustophoresis device. These methods and systems can deflect material (e.g., a second fluid, cells, beads or other particles, exosomes, viruses, oil droplets) in host fluid streams at high flow rates.
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公开(公告)号：US20200308533A1
公开(公告)日：2020-10-01
申请号：US16880787
申请日：2020-05-21
发明人： Bart Lipkens , Erik Miller , Benjamin Ross-Johnsrud , Walter M. Presz, JR. , Kedar Chitale , Thomas J. Kennedy, III , Lauryn Winiarski
摘要： Acoustic perfusion devices for separating biological cells from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.
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公开(公告)号：US20190011407A9
公开(公告)日：2019-01-10
申请号：US15963809
申请日：2018-04-26
发明人： Bart Lipkens , Rui Tostoes , Kedar C. Chitale , Benjamin Ross-Johnsrud , Walter M. Presz, JR. , Jack Saloio
IPC分类号： G01N30/76 , G01N30/46 , G01N30/72 , G01N33/543
摘要： Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.
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公开(公告)号：USD797887S1
公开(公告)日：2017-09-19
申请号：US29562478
申请日：2016-04-26
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公开(公告)号：US20170217794A1
公开(公告)日：2017-08-03
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, JR. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
CPC分类号： C02F1/36 , B01D17/04 , B01D17/041 , B01D17/044 , B01D19/0078 , B01D21/28 , B06B1/0622 , B06B1/0644 , C02F1/40 , C12M35/04 , C12M47/02 , C12N1/02 , C12N13/00 , G10K11/28 , H01L41/0913
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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公开(公告)号：US20160339360A1
公开(公告)日：2016-11-24
申请号：US15161108
申请日：2016-05-20
CPC分类号： B01D21/283 , B01D17/00 , B01D17/0202 , B01D21/0084 , B01D43/00 , B06B1/0607 , C12M47/02 , C12M47/04 , C12M47/10
摘要： A method for separating a second fluid or a particulate from a host fluid is disclosed. The method includes flowing the mixture through an acoustophoretic device comprising an acoustic chamber, an ultrasonic transducer, and a reflector. The transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber. A voltage signal is sent to drive the ultrasonic transducer in a displacement profile that is a superposition of a combination of different mode shapes that are the same order of magnitude to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.
摘要翻译： 公开了一种从主流体分离第二流体或颗粒的方法。 该方法包括使混合物流过包括声学室，超声换能器和反射器的声学装置。 换能器包括由电压信号驱动以在声室中产生多维声驻波的压电材料。 发送电压信号以驱动超声波换能器的位移曲线，该位移曲线是相同数量级的不同模式形状的组合的叠加，以在声学室中产生多维声驻波使得第二流体 或颗粒物被连续地捕获在驻波中，然后聚集，聚集，团块或聚结在一起，并且随后由于浮力或重力而升高或沉降在主体流体中，并且离开声室。
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公开(公告)号：US11474085B2
公开(公告)日：2022-10-18
申请号：US15963809
申请日：2018-04-26
发明人： Bart Lipkens , Rui Tostoes , Kedar C. Chitale , Benjamin Ross-Johnsrud , Walter M. Presz, Jr. , Jack Saloio
IPC分类号： G01N30/76 , G01N30/46 , G01N30/72 , G01N33/543 , B01D15/38 , B01D15/18 , C07K1/22 , G01N30/02 , C12M1/42 , C12N13/00
摘要： Separation of materials is achieved using affinity binding and acoustophoretic techniques. A column provided with a fluid mixture of materials for separation and support structures may be used with acoustic waves to block flow of the support structures. The support structures can have an affinity for one or more materials in the fluid mixture. By blocking flow of the support structures, materials bound or adhered to the support structure are also blocked.
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公开(公告)号：US10322949B2
公开(公告)日：2019-06-18
申请号：US15490878
申请日：2017-04-18
发明人： Bart Lipkens , Walter M. Presz, Jr. , Kedar Chitale , Brian McCarthy , Benjamin Ross-Johnsrud , Thomas J. Kennedy, III , Dane Mealey , Brian Dutra , David Sokolowski
IPC分类号： C02F1/36 , B06B1/06 , B01D17/04 , C02F1/40 , B01D19/00 , B01D21/28 , C12M1/42 , G10K11/28 , C12N1/02 , C12N13/00 , C12M1/00 , H01L41/09
摘要： Separation of particles or droplets from a host fluid may be achieved using a transducer and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves operation of an acoustic standing wave generated by an acoustic transducer. The structure may operate as a pressure release boundary and may be constructed as plastic film.
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公开(公告)号：US20180362918A1
公开(公告)日：2018-12-20
申请号：US16010296
申请日：2018-06-15
发明人： Bart Lipkens , Rui Tostoes , Brian Dutra , Rudolf Gilmanshin , Jason Dionne , Walter M. Presz, JR. , Benjamin Ross-Johnsrud , Goutam Ghoshal , Kedar Chitale
摘要： A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.
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