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公开(公告)号:US09783775B2
公开(公告)日:2017-10-10
申请号:US15432737
申请日:2017-02-14
发明人: Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, Jr. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC分类号: C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B01J19/10 , B01J19/18 , B06B1/0644 , C02F1/36 , C02F3/00 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/10 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/10
摘要: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号:US09688958B2
公开(公告)日:2017-06-27
申请号:US15245112
申请日:2016-08-23
IPC分类号: C12N13/00 , C12N5/0783 , C12M1/42 , C12M1/00 , B01D17/04 , B01D17/06 , B01D21/28 , B06B1/06 , C07K1/14
CPC分类号: C12N5/0636 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0622 , C07K1/145 , C12M29/04 , C12M35/02 , C12M35/04 , C12M47/02 , C12M47/10 , C12N13/00 , C12N2510/00
摘要: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. The nutrient fluid stream dislodges some cells from the cell culture, which can then be recovered for cell therapy applications. The cell culture continues to expand and reproduce, permitting continuous recovery of cells from the bioreactor.
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公开(公告)号:US20170175073A1
公开(公告)日:2017-06-22
申请号:US15453582
申请日:2017-03-08
发明人: Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin , John Rozembersky
IPC分类号: C12M1/00
CPC分类号: C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B01J19/10 , B01J19/18 , B01J2219/00094 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/10 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02
摘要: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号:US20160369236A1
公开(公告)日:2016-12-22
申请号:US15245112
申请日:2016-08-23
IPC分类号: C12N5/0783 , C12M1/42 , C12M1/00 , C12N13/00
CPC分类号: C12N5/0636 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0622 , C07K1/145 , C12M29/04 , C12M35/02 , C12M35/04 , C12M47/02 , C12M47/10 , C12N13/00 , C12N2510/00
摘要: A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. The nutrient fluid stream dislodges some cells from the cell culture, which can then be recovered for cell therapy applications. The cell culture continues to expand and reproduce, permitting continuous recovery of cells from the bioreactor.
摘要翻译: 在生物反应器的生长体积内建立一系列多维声驻波。 声波驻波被用于将细胞培养物保持在适当的位置,因为营养液流流过细胞培养物。 营养液流从细胞培养物中除去一些细胞,然后将其回收用于细胞治疗应用。 细胞培养继续扩大和繁殖,允许从生物反应器连续回收细胞。
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公开(公告)号:US09512395B2
公开(公告)日:2016-12-06
申请号:US14533753
申请日:2014-11-05
发明人: Bart Lipkens , Jason Barnes , Dane Mealey , Walter M. Presz, Jr. , Stanley Kowalski, III , Louis Masi , Thomas J. Kennedy, III , Brian McCarthy , Ben Ross-Johnsrud
CPC分类号: C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
摘要: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
摘要翻译: 公开了一种由模块化部件组成的消声器。 本文公开了多个模块,包括超声换能器模块,输入/输出模块,收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒(例如生物细胞)的适当流体动力学的不同系统。
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公开(公告)号:US09272234B2
公开(公告)日:2016-03-01
申请号:US13943529
申请日:2013-07-16
发明人: Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
CPC分类号: B01D17/04 , B01D43/00 , B06B1/0644 , C12M47/02
摘要: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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7.
公开(公告)号:US20150274550A1
公开(公告)日:2015-10-01
申请号:US14711627
申请日:2015-05-13
发明人: Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, JR. , Thomas J. Kennedy, III , Louis Masi
CPC分类号: C02F1/36 , B01D17/045 , B01D17/12 , B01D21/283 , B01D43/00 , B06B1/0644 , C02F1/40 , C02F2103/007 , C02F2103/10
摘要: An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
摘要翻译: 使用声驻波在具有声流装置的流体流动方案中将组分与多组分流体(例如来自油 - 水混合物的油)分离。 例如,流动方案和装置允许在油聚结,聚集并且变得比水更浮力时捕获油。
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公开(公告)号:US20140154795A1
公开(公告)日:2014-06-05
申请号:US14175766
申请日:2014-02-07
发明人: Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
IPC分类号: C12M1/12
CPC分类号: C12M25/00 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M29/10 , C12M33/08 , C12M35/04 , C12M47/02 , H01L41/0973
摘要: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
摘要翻译: 灌注生物反应器包括至少一个可声学地产生多维驻波的超声换能器。 驻波可用于将细胞保留在生物反应器中,并且也可用于从生物反应器中生产的废物中脱水或进一步收获产品。
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公开(公告)号:US20170204360A1
公开(公告)日:2017-07-20
申请号:US15475469
申请日:2017-03-31
发明人: Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin
CPC分类号: C12M47/10 , B01D17/04 , B01D17/06 , B01D21/283 , B06B1/0644 , C12M23/14 , C12M23/22 , C12M27/00 , C12M27/02 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/02 , C12M47/04 , C12P21/02
摘要: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号:US20170191022A1
公开(公告)日:2017-07-06
申请号:US15466289
申请日:2017-03-22
发明人: Bart Lipkens , Louis Masi , Stanley Kowalski, III , Walter M. Presz, JR. , Jason Dionne , Brian Dutra , Ari Mercado , Thomas J. Kennedy, III , Arthur Martin , John Rozembersky
CPC分类号: C12M47/02 , B01D17/04 , B01D17/06 , B01D21/283 , B01J19/10 , B01J19/18 , B01J2219/00094 , B06B1/0644 , C02F1/004 , C02F1/36 , C02F1/40 , C02F3/1268 , C02F11/12 , C12M23/14 , C12M23/22 , C12M27/02 , C12M29/02 , C12M29/04 , C12M29/18 , C12M33/08 , C12M33/14 , C12M35/04 , C12M47/10 , Y02W10/15
摘要: A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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