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公开(公告)号：US20190241608A1
公开(公告)日：2019-08-08
申请号：US16386628
申请日：2019-04-17
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Jean-Luc Maloisel , Ola Lind , Bjorn Noren , Ronnie Palmgren
CPC classification number: C07K1/22 , C07K1/145 , C07K16/00 , C07K16/065 , C07K2317/55
Abstract: The present invention relates to a method for removal of large contaminants, such as virus, in a chromatographic process for purification of a target molecule, preferably monoclonal antibodies, mAbs, by using a specifically designed chromatographic bead having a thin outer layer and a core functionalized with a ligand adsorbing the mAbs or parts thereof.
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公开(公告)号：US10266563B2
公开(公告)日：2019-04-23
申请号：US15308327
申请日：2015-06-04
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Jean-Luc Maloisel , Ola Lind , Bjorn Noren , Ronnie Palmgren
Abstract: The present invention relates to a method for removal of large contaminants, such as virus, in a chromatographic process for purification of a target molecule, preferably monoclonal antibodies, mAbs, by using a specifically designed chromatographic bead having a thin outer layer and a core functionalized with a ligand adsorbing the mAbs or parts thereof.
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公开(公告)号：US20170247407A1
公开(公告)日：2017-08-31
申请号：US15596040
申请日：2017-05-16
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Hans J. Johansson , Ronnie Palmgren
IPC: C07K1/22 , B01D15/38 , B01J20/285 , C07K14/31 , B01J20/289
CPC classification number: C07K1/22 , B01D15/34 , B01D15/3809 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3274 , C07K14/245 , C07K14/31 , C07K2319/00
Abstract: The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein Z or the C domain of protein A or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin-containing proteins.
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公开(公告)号：US20170051010A1
公开(公告)日：2017-02-23
申请号：US15308327
申请日：2015-06-04
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Jean-Luc Maloisel , Ola Lind , Bjorn Noren , Ronnie Palmgren
CPC classification number: C07K1/22 , C07K1/145 , C07K16/00 , C07K16/065 , C07K2317/55
Abstract: The present invention relates to a method for removal of large contaminants, such as virus, in a chromatographic process for purification of a target molecule, preferably monoclonal antibodies, mAbs, by using a specifically designed chromatographic bead having a thin outer layer and a core functionalized with a ligand adsorbing the mAbs or parts thereof.
Abstract translation: 本发明涉及在用于纯化目标分子的色谱方法（优选单克隆抗体mAb）中通过使用具有薄的外层和核心功能化的专门设计的色谱珠来去除大污染物如病毒的方法 具有吸附mAb或其部分的配体。
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Patent Agency Ranking
公开(公告)号：US10662261B2
公开(公告)日：2020-05-26
申请号：US15937428
申请日：2018-03-27
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Mattias Algotsson , Lars C. Andersson , Eggert Brekkan , Lee Hedemyr , Jean-Luc Maloisel , Ronnie Palmgren
IPC: C08B37/00 , B01J20/289 , B01J20/32 , C07C237/10 , C07C323/60 , B01J20/281
Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.
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公开(公告)号：US20190184358A1
公开(公告)日：2019-06-20
申请号：US16328129
申请日：2017-09-04
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Jimmy Hedin Dahlstrom , Jonas Bengtsson , Per Erik Emilsson , Maranda Fordham , Eva Holmgren , Ronnie Palmgren , Fernando Polanco
CPC classification number: B01J2/06 , B01F3/0811 , B01F5/0696 , B01F2003/0834 , B01F2003/0842
Abstract: A system and method for producing fine droplets of polysaccharide from a premixed water-in-oil emulsion uses a packed bed (5) comprising hydrophilic beads (7).
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公开(公告)号：US20190381480A1
公开(公告)日：2019-12-19
申请号：US16486653
申请日：2018-02-15
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Ronnie Palmgren , Jean-Luc Maloisel , Gustav Rodrigo , Tomas Bjorkman
Abstract: A separation matrix comprising porous particles to which antibody-binding protein ligands have been covalently immobilized, wherein the density of said ligands is above 5 mg/ml, the volume-weighted median diameter of said porous particles is at least 10 and below 30 μm and the said porous particles have a gel phase distribution coefficient, expressed as KD for dextran of molecular weight 110 kDa, of 0.5-0.9.
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公开(公告)号：US20180223003A1
公开(公告)日：2018-08-09
申请号：US15937428
申请日：2018-03-27
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Mattias Algotsson , Lars C. Andersson , Eggert Brekkan , Lee Hedemyr , Jean-Luc Maloisel , Ronnie Palmgren
IPC: C08B37/00 , C07C323/60 , C07C237/10 , B01J20/32 , B01J20/281 , B01J20/289
CPC classification number: C08B37/0039 , B01J20/281 , B01J20/289 , B01J20/3219 , B01J20/3251 , B01J20/3265 , C07C237/10 , C07C323/60
Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.
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公开(公告)号：US09657055B2
公开(公告)日：2017-05-23
申请号：US14358821
申请日：2012-11-28
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Hans J. Johansson , Ronnie Palmgren
IPC: B01D15/38 , C07K1/22 , C07K14/31 , C07K19/00 , B01J20/286 , B01J20/32 , C07K14/245 , B01D15/34
CPC classification number: C07K1/22 , B01D15/34 , B01D15/3809 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3274 , C07K14/245 , C07K14/31 , C07K2319/00
Abstract: The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein Z or the C domain of protein A or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin-containing proteins.
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