公开(公告)号：US20140088314A1

公开(公告)日：2014-03-27

申请号：US13626918

申请日：2012-09-26

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Brian James Grimmond ,  Michael James Rishel

IPC: C07F9/40 ,  C07C229/16 ,  C07F19/00 ,  C07F7/10

CPC classification number: C07F15/025 ,  A61K49/103 ,  C07C229/16 ,  C07C229/76 ,  C07F7/0812 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/409 ,  C07F9/65586 ,  Y02P20/55

Abstract: A chelating agent, a metal-chelate, and a contrast agent are provided, wherein the chelating agent comprises a compound of structure (I) wherein R1, R2, R3, R8, R7, R′7 R′1, R′2, R′3 and R8′ are selected from a hydrogen, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; R4 and R′4 are selected from a hydrogen, a hydroxyl group, a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5 and R′5 are selected from a hydrogen, a protecting group selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals; R9 and R′9 are selected form a hydrogen or a protecting group selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 0 and 10; and at least one of R7 and R′7 is acidic group or a protected acidic group.

Abstract translation: 提供螯合剂，金属螯合物和造影剂，其中螯合剂包括结构式（I）的化合物，其中R1，R2，R3，R8，R7，R'7R'1，R'2， R'3和R 8'选自氢，被保护的C 1 -C 3羟烷基，C 1 -C 3烷基; R 4和R 4选自氢，羟基，保护的羟基，被保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R 5和R 5选自氢，选自C 1 -C 30脂族基，C 3 -C 30脂环族基，C 2 -C 30芳族基的保护基; R 9和R 9选自由C 1 -C 30脂族基团，C 3 -C 30脂环族基团，C 2 -C 30芳族基团组成的组中的氢或保护基团，m为0至10的整数; 并且R 7和R 7中的至少一个是酸性基团或被保护的酸性基团。

公开(公告)号：US09155804B2

公开(公告)日：2015-10-13

申请号：US13626942

申请日：2012-09-26

Applicant: General Electric Company

Inventor： Brian James Grimmond ,  Michael James Rishel ,  Jeannette Christine Roberts

IPC: A61K51/00 ,  A61M36/14 ,  A61K49/12

CPC classification number: A61K49/126

Abstract: A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.

Abstract translation: 提供造影剂组合物和诊断成像方法。 该组合物包含药学上可接受的载体和包含具有结构（XXX）的配体的金属络合物：其中R1，R2，R3，R7，R8，R'1，R'2，R'3，R7'和R8'是 选自氢，受保护的C1-C3羟烷基或C1-C3烷基; R 4，R'4选自氢，羟基，被保护的羟基，保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R5，R'5选自氢，包含C1-C30脂族基团，C3-C30脂环族基团，C2-C30芳族基团的保护基，m是1-10之间的整数; R 7和R 7中的至少一个是酸性基团或被保护的酸性基团; Y包括蛋白质或肽部分，颗粒，胶束，脂质体，有机分子，低聚物，聚合物或亲水部分。

公开(公告)号：US20150198580A1

公开(公告)日：2015-07-16

申请号：US14153315

申请日：2014-01-13

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Brian James Grimmond ,  Brian Christopher Bales ,  Alex David Corwin ,  Adriana Ines Larriera Moreno ,  Christine Lynne Pitner

IPC: G01N33/483

CPC classification number: G01N33/4833 ,  B01L3/508 ,  B01L2300/041 ,  B01L2300/0822 ,  G01N2035/00138 ,  G02B21/34

Abstract: The invention provides a coverslip for automated decoverslipping of a tissue bearing slide comprising a horizontal base portion having a length, width, and height, at least two side wall portions extending downward from opposite sides of the base portion each having a length and width and h; and wherein the total wall volume to base volume ratio is greater than or equal to approximately 0.025.

Abstract translation: 本发明提供一种盖玻片，用于组织支承滑动件的自动倒瓶，其包括具有长度，宽度和高度的水平基部，至少两个侧壁部分，其从基部的相对侧向下延伸，每个侧壁具有长度和宽度，并且h ; 并且其中总壁体积与基体积体积比大于或等于大约0.025。

公开(公告)号：US20150285720A1

公开(公告)日：2015-10-08

申请号：US14247353

申请日：2014-04-08

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Bruce Allan Hay ,  Brian James Grimmond ,  Lisa Anne Lowery ,  Qing Li ,  Patrick McCoy Spooner ,  Christine Angela Morton

IPC: G01N1/42 ,  C12Q1/68 ,  G01N33/483

CPC classification number: C12Q1/6806 ,  G01N33/4833 ,  C12Q2527/101 ,  C12Q2527/125

Abstract: Disclosed are novel cold fixation methods and reagents comprising contacting a biological sample with a reagent for fixation at a temperature of less than 20° C. where the reagent comprises an aqueous buffer, a water soluble alkylnitrile, C2 to C6 alkyl ester, or combination thereof, and formaldehyde to the aqueous buffer solution and removing the biological sample from contact with the reagent.

Abstract translation: 公开了新颖的冷固定方法和试剂，包括使生物样品与低于20℃的温度的试剂接触，其中试剂包含水性缓冲液，水溶性烷基腈，C2至C6烷基酯或其组合 ，并将甲醛加入到缓冲溶液中，并将生物样品与试剂接触。

公开(公告)号：US20140086846A1

公开(公告)日：2014-03-27

申请号：US13626942

申请日：2012-09-26

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Brian James Grimmond ,  Michael James Rishel ,  Jeannette Christine Roberts

IPC: A61K49/00 ,  A61K49/14 ,  C07H21/00 ,  C07K14/00 ,  C07K16/00 ,  C07H99/00 ,  A61K49/10 ,  A61K49/16

CPC classification number: A61K49/126

Abstract: A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.

Abstract translation: 提供造影剂组合物和诊断成像方法。 该组合物包含药学上可接受的载体和包含具有结构（XXX）的配体的金属络合物：其中R1，R2，R3，R7，R8，R'1，R'2，R'3，R7'和R8'是 选自氢，受保护的C1-C3羟烷基或C1-C3烷基; R 4，R'4选自氢，羟基，被保护的羟基，保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R5，R'5选自氢，包含C1-C30脂族基团，C3-C30脂环族基团，C2-C30芳族基团的保护基，m是1-10之间的整数; R 7和R 7中的至少一个是酸性基团或被保护的酸性基团; Y包括蛋白质或肽部分，颗粒，胶束，脂质体，有机分子，低聚物，聚合物或亲水部分。