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    Method of isolation of polypeptide-aptamer-polymer conjugates
    1.
    发明授权
    Method of isolation of polypeptide-aptamer-polymer conjugates 有权

    公开(公告)号：US10450345B2

    公开(公告)日：2019-10-22

    申请号：US15619148

    申请日：2017-06-09

    Applicant: General Electric Company

    Inventor： Erik Leeming Kvam ,  Bruce Allan Hay ,  Ernest William Kovacs

    IPC: C07K1/36 ,  C08L71/02 ,  C07K16/00 ,  B01D11/04 ,  C12N15/11 ,  B01D17/02 ,  C07K1/14 ,  B01J20/26 ,  B01D15/38 ,  C12N15/115

    Abstract: A method for purification of a target in a solution includes providing a target in a solution, the solution comprising one or more contaminants, providing a polymer conjugate in the solution, wherein the polymer conjugate is configured to specifically bind the target, incubating the solution at a first temperature to facilitate binding of the polymer conjugate to the target, providing an environmentally-responsive block copolymer in the solution, wherein the environmentally-responsive block copolymer comprises one or more of an ethylene oxide (EO), a propylene oxide (PO), or an EO/PO block copolymer, and heating the solution comprising the environmentally-responsive block copolymer and the polymer conjugate bound to the target at a second temperature to initiate a liquid-liquid phase separation, wherein the liquid-liquid phase separation produces an aqueous phase and a liquid polymer phase, and wherein the liquid polymer phase comprises the polymer conjugate bound to the target.

    Systems and methods for magnetic material imaging
    2.
    发明授权
    Systems and methods for magnetic material imaging 有权

    公开(公告)号：US09846206B2

    公开(公告)日：2017-12-19

    申请号：US13970339

    申请日：2013-08-19

    Applicant: General Electric Company

    Inventor： Dominic Michael Graziani ,  Thomas Kwok-Fah Foo ,  Luca Marinelli ,  Daniel Eugene Meyer ,  Bruce Allan Hay

    IPC: G01N27/72 ,  A61B5/00 ,  G01R33/12 ,  A61B5/05

    CPC classification number: G01R33/1276 ,  A61B5/00 ,  A61B5/0515

    Abstract: Magnetic material imaging (MMI) system including first and second sets of field-generating coils. Each of the field-generating coils of the first and second sets has an elongated segment that extends along an imaging axis of the medical imaging system. The imaging axis extends through a region-of-interest (ROI) of an object. The elongated segments of the first set of field-generating coils are positioned opposite the elongated segments of the second set of field-generating coils and the ROI is located between the first and second sets of field-generating coils. The MMI system also includes a coil-control module configured to control a flow of current through the first and second sets of field-generating coils to generate a selection field and to generate a drive field. The selection and drive fields combine to form a movable 1D field free region (FFR) that extends through the ROI.

    LABELED MOLECULAR IMAGING AGENTS AND METHODS OF USE
    5.
    发明申请
    LABELED MOLECULAR IMAGING AGENTS AND METHODS OF USE 有权
    标记分子成像剂及其使用方法

    公开(公告)号：US20150202333A1

    公开(公告)日：2015-07-23

    申请号：US14161863

    申请日：2014-01-23

    Applicant: General Electric Company

    Inventor： Bruce Allan Hay ,  Jack Mathew Webster

    IPC: A61K51/04 ,  G01N33/50 ,  A61K49/00

    CPC classification number: A61K51/0446 ,  A61K49/0004 ,  A61K51/0406 ,  C07B59/002 ,  G01N33/5091

    Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

    Abstract translation: 描述了包含能够通过胱氨酸/谷氨酸反向转运体引入细胞的标记底物的成像剂。 通过将标记的试剂通过胱氨酸/谷氨酸反转录酶引入细胞并随后检测，底物可用于成像或检测细胞中的氧化应激。

    METHOD OF ISOLATION OF POLYPEPTIDE-APTAMER-POLYMER CONJUGATES
    6.
    发明申请
    METHOD OF ISOLATION OF POLYPEPTIDE-APTAMER-POLYMER CONJUGATES 审中-公开

    公开(公告)号：US20180354987A1

    公开(公告)日：2018-12-13

    申请号：US15619148

    申请日：2017-06-09

    Applicant: General Electric Company

    Inventor： Erik Leeming Kvam ,  Bruce Allan Hay ,  Ernest William Kovacs

    IPC: C07K1/36 ,  C12N15/115 ,  C08F20/56 ,  C08L71/02 ,  C08L33/26 ,  C07K16/00 ,  B01D11/04

    Abstract: A method for purification of a target in a solution includes providing a target in a solution, the solution comprising one or more contaminants, providing a polymer conjugate in the solution, wherein the polymer conjugate is configured to specifically bind the target, incubating the solution at a first temperature to facilitate binding of the polymer conjugate to the target, providing an environmentally-responsive block copolymer in the solution, wherein the environmentally-responsive block copolymer comprises one or more of an ethylene oxide (EO), a propylene oxide (PO), or an EO/PO block copolymer, and heating the solution comprising the environmentally-responsive block copolymer and the polymer conjugate bound to the target at a second temperature to initiate a liquid-liquid phase separation, wherein the liquid-liquid phase separation produces an aqueous phase and a liquid polymer phase, and wherein the liquid polymer phase comprises the polymer conjugate bound to the target.

    Labeled molecular imaging agents and methods of use
    7.
    发明授权
    Labeled molecular imaging agents and methods of use 有权
    标记分子成像剂和使用方法

    公开(公告)号：US09468693B2

    公开(公告)日：2016-10-18

    申请号：US14161863

    申请日：2014-01-23

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Bruce Allan Hay ,  Jack Mathew Webster

    IPC: A61K49/00 ,  A61K51/04 ,  G01N33/50

    CPC classification number: A61K51/0446 ,  A61K49/0004 ,  A61K51/0406 ,  C07B59/002 ,  G01N33/5091

    Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.

    Abstract translation: 描述了包含能够通过胱氨酸/谷氨酸反向转运体引入细胞的标记底物的成像剂。 通过将标记的试剂通过胱氨酸/谷氨酸反转录酶引入细胞并随后检测，底物可用于成像或检测细胞中的氧化应激。

    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS
    10.
    发明申请
    TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS 有权
    用水解ALPHA-羟基磷酸共聚物处理水不溶性纳米颗粒，该改性纳米粒子及其作为对比剂的用途

    公开(公告)号：US20160038617A1

    公开(公告)日：2016-02-11

    申请号：US14919077

    申请日：2015-10-21

    Applicant: General Electric Company

    Inventor： Brian Christopher Bales ,  Bruce Allan Hay ,  Binil Itty Ipe Kandapallil

    IPC: A61K49/18

    CPC classification number: A61K49/1857 ,  A61K49/0428 ,  A61K49/1842 ,  A61K49/186 ,  B82Y5/00

    Abstract: The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.

    Abstract translation: 本申请公开了处理水不溶性纳米颗粒，特别是金属和金属化合物的纳米颗粒，其在诊断成像如MR和X射线成像中具有与亲水部分的α-羟基膦酸缀合物的效用，以使纳米颗粒充分亲水以发现 在诊断成像中的应用。 所公开的改性亲水性纳米粒子中的那些是其中改性缀合物的亲水部分是环氧乙烷基聚合物和共聚物和两性离子，并且纳米颗粒由过渡金属氧化物如超顺磁性氧化铁和氧化钽组成。 公开了足够亲水以形成稳定的水性胶体悬浮液的纳米颗粒。 还公开了使用修饰的亲水性纳米颗粒作为造影剂的诊断成像如MR和X射线。

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