-
公开(公告)号：US20150198580A1
公开(公告)日：2015-07-16
申请号：US14153315
申请日：2014-01-13
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brian James Grimmond , Brian Christopher Bales , Alex David Corwin , Adriana Ines Larriera Moreno , Christine Lynne Pitner
IPC: G01N33/483
CPC classification number: G01N33/4833 , B01L3/508 , B01L2300/041 , B01L2300/0822 , G01N2035/00138 , G02B21/34
Abstract: The invention provides a coverslip for automated decoverslipping of a tissue bearing slide comprising a horizontal base portion having a length, width, and height, at least two side wall portions extending downward from opposite sides of the base portion each having a length and width and h; and wherein the total wall volume to base volume ratio is greater than or equal to approximately 0.025.
Abstract translation: 本发明提供一种盖玻片，用于组织支承滑动件的自动倒瓶，其包括具有长度，宽度和高度的水平基部，至少两个侧壁部分，其从基部的相对侧向下延伸，每个侧壁具有长度和宽度，并且h ; 并且其中总壁体积与基体积体积比大于或等于大约0.025。
-
公开(公告)号：US20140248618A1
公开(公告)日：2014-09-04
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: C12Q1/68 , G01N33/543
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
-
公开(公告)号：US09797767B2
公开(公告)日：2017-10-24
申请号：US14469362
申请日：2014-08-26
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: G01J1/0228 , G01N21/274 , G01N21/64 , G01N21/6458 , G02B21/365
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
-
公开(公告)号：US20170175105A1
公开(公告)日：2017-06-22
申请号：US15453719
申请日：2017-03-08
Applicant: General Electric Company
Inventor： John Richard Nelson , Wei Gao , Christopher Michael Puleo , Todd Frederick Miller , Christine Lynne Pitner , David Andrew Shoudy , Alex David Corwin
CPC classification number: C12N15/1013 , B01L3/502 , B01L2200/025 , B01L2200/0689 , B01L2300/06 , B01L2300/0654 , B01L2300/0861 , C12Q1/6806 , G01N1/02 , G01N1/10 , G01N1/40 , G01N2001/028 , G01N2001/4038
Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base, a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
-
公开(公告)号：US09581800B2
公开(公告)日：2017-02-28
申请号：US14550187
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Alex David Corwin , Kevin Bernard Kenny , Christine Lynne Pitner
CPC classification number: G02B21/34 , B01L9/52 , B01L2200/025 , B01L2300/0822 , G02B27/32
Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.
Abstract translation: 本发明提供了一种利用边缘检测算法来确定幻灯片的各种边缘的位置的滑块架。 从这些边缘，并整合特征滑动尺寸，确定支架中滑块边缘的线性偏移和滑块相对于显微镜载物台轴线的任何旋转。 使用本发明的滑块保持器的过程确保在第一轮成像期间精确和准确地放置滑块，并在随后的回合中重新加载。
-
Patent Agency Ranking
公开(公告)号：US09150907B2
公开(公告)日：2015-10-06
申请号：US14277836
申请日：2014-05-15
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Kashan Ali Shaikh , Mengli Wang , Adriana Ines Larriera Moreno , Jessica Godin Karp , Christine Lynne Pitner
IPC: G01N1/28 , G01N21/64 , C12Q1/68 , G01N33/543 , B01L3/00 , B01L9/00 , B32B37/00 , B32B37/18 , B32B38/00
CPC classification number: C12Q1/6813 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2300/0816 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B32B37/0076 , B32B37/182 , B32B38/0008 , B32B2535/00 , G01N33/54306
Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.
Abstract translation: 描述了可以组装成具有在主底物外部的流体连接的流动池的微流体流动池子组件，用于封装样品以允许随后控制的试剂递送到样品中，例如原位复合生物标记染色和分析 。 流体连接器是能够连接到流体输送系统的薄膜流体连接器。 子组件可以密封在固体支撑件上以形成流动池。 还公开了使用方法。
-
公开(公告)号：US09625355B2
公开(公告)日：2017-04-18
申请号：US14557169
申请日：2014-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： John Richard Nelson , Wei Gao , Christopher Michael Puleo , Todd Frederick Miller , Christine Lynne Pitner , David Andrew Shoudy , Alex David Corwin
CPC classification number: C12N15/1013 , B01L3/502 , B01L2200/025 , B01L2200/0689 , B01L2300/06 , B01L2300/0654 , B01L2300/0861 , C12Q1/6806 , G01N1/02 , G01N1/10 , G01N1/40 , G01N2001/028 , G01N2001/4038
Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base; a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
-
公开(公告)号：US20160153868A1
公开(公告)日：2016-06-02
申请号：US14557169
申请日：2014-12-01
Applicant: GENERAL ELECTRIC COMPANY
Inventor： John Richard Nelson , Wei Gao , Christopher Michael Puleo , Todd Frederick Miller , Christine Lynne Pitner , David Andrew Shoudy , Alex David Corwin
IPC: G01N1/10
CPC classification number: C12N15/1013 , B01L3/502 , B01L2200/025 , B01L2200/0689 , B01L2300/06 , B01L2300/0654 , B01L2300/0861 , C12Q1/6806 , G01N1/02 , G01N1/10 , G01N1/40 , G01N2001/028 , G01N2001/4038
Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base; a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.
Abstract translation: 用于从感兴趣区域提取材料的系统包括流体输送基底，其包括形成在流体输送基底内的入口通道和出口通道; 固定到流体输送基座上的垫圈，其中垫圈包括暴露入口通道的开口端和出口通道的开口端的至少一个开口; 支撑件，其包括面向所述垫圈的样品支撑表面和相对表面; 以及对准构件，其在固定位置联接到所述相对表面，并且使得所述支撑件定位在所述流体输送基座和所述对准构件之间，其中所述对准构件或所述流体输送基座中的一个或两个被朝向彼此偏置 力（例如，磁体或弹簧力），并且其中流体输送基座可与支撑件分离并且构造成沿着样品支撑表面的平面移动以与对准构件对准。
-
公开(公告)号：US20160147056A1
公开(公告)日：2016-05-26
申请号：US14550187
申请日：2014-11-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Alex David Corwin , Kevin Bernard Kenny , Christine Lynne Pitner
IPC: G02B21/34
CPC classification number: G02B21/34 , B01L9/52 , B01L2200/025 , B01L2300/0822 , G02B27/32
Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.
Abstract translation: 本发明提供了一种利用边缘检测算法来确定幻灯片的各种边缘的位置的滑块架。 从这些边缘，并整合特征滑动尺寸，确定支架中滑块边缘的线性偏移和滑块相对于显微镜载物台轴线的任何旋转。 使用本发明的滑块保持器的过程确保在第一轮成像期间精确和准确地放置滑块，并在随后的回合中重新加载。
-
公开(公告)号：US20160061654A1
公开(公告)日：2016-03-03
申请号：US14469362
申请日：2014-08-26
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: G01J1/0228 , G01N21/274 , G01N21/64 , G01N21/6458 , G02B21/365
Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.
Abstract translation: 公开了用于校准诸如显微镜的多个成像装置的方法。 在某些实施方案中，采用包括各种校准特征的校准板。 根据本方法校准的成像装置可用于生成具有一致属性（例如亮度）的图像，而不管采用何种成像装置。
-
-
-
-
-
-
-
-
-
Search Results
12
records
(took 0.017 seconds)
