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    SYSTEM AND METHOD FOR ATTACHING A BIOPSY COLLECTING DEVICE TO A SPECTROSCOPY SYSTEM
    2.
    发明申请
    SYSTEM AND METHOD FOR ATTACHING A BIOPSY COLLECTING DEVICE TO A SPECTROSCOPY SYSTEM 有权
    将生物收集装置连接到光谱系统的系统和方法

    公开(公告)号：US20150185140A1

    公开(公告)日：2015-07-02

    申请号：US14657204

    申请日：2015-03-13

    Applicant: General Electric Company

    Inventor： Siavash Yazdanfar ,  Victor Petrovich Ostroverkhov ,  Dmitry Vladimirovich Dylov ,  Stephen B. Solomon ,  Jeremy C. Durack

    IPC: G01N21/27

    CPC classification number: A61B10/0275 ,  A61B10/0233

    Abstract: A method for classifying a tissue sample of a biopsy specimen includes receiving a signal from at least one location of the tissue sample including a plurality of chromophores. Further, the method includes verifying whether the received signal comprises a predetermined amount of at least one of an attenuated illumination light and a re-emitted light. Also, the method includes determining that a spectrum of the received signal is within a predetermined range. In addition, the method includes processing the spectrum of the received signal to decompose the signal into a plurality of components. Furthermore, the method includes classifying tissue in the at least one location of the tissue sample into one of a plurality of tissue types based on the plurality of components.

    Abstract translation: 用于分类活检标本的组织样本的方法包括从包括多个发色团的组织样本的至少一个位置接收信号。 此外，该方法包括验证接收信号是否包括预定量的衰减照明光和再发射光中的至少一种。 此外，该方法包括确定接收信号的频谱在预定范围内。 此外，该方法包括处理接收信号的频谱以将信号分解为多个分量。 此外，该方法包括基于多个组件将组织样本的至少一个位置中的组织分类为多个组织类型之一。

    System and method for optical biopsy tissue characterization
    3.
    发明授权
    System and method for optical biopsy tissue characterization 有权
    光学活检组织表征的系统和方法

    公开(公告)号：US08912512B1

    公开(公告)日：2014-12-16

    申请号：US13927543

    申请日：2013-06-26

    Applicant: General Electric Company

    Inventor： Rajesh Veera Venkata Lakshmi Langoju ,  Abhijit Vishwas Patil ,  Sridhar Dasaratha ,  Vignesh Thirukazhukundram Subrahmaniam ,  Dmitry Vladimirovich Dylov ,  Siavash Yazdanfar ,  Stephen B. Solomon

    IPC: G01N21/64

    CPC classification number: G01N21/31 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/6849

    Abstract: A method for classifying a tissue sample of a biopsy specimen into one of a plurality of classes is presented. The method includes receiving a light from at least one location of the tissue sample including a plurality of chromophores, wherein the received light comprises at least one of an attenuated illumination light and a re-emitted light. The method further includes processing a spectrum of the received light to determine a feature for each of the chromophores in the at least one location of the tissue sample. In addition, the method includes estimating a Z-score for each of the chromophores based on the determined feature. Also, the method includes classifying the tissue sample into one of the plurality of classes based on the estimated Z-score for each of the chromophores.

    Abstract translation: 提出了将活检标本的组织样本分类为多个类别之一的方法。 该方法包括从包括多个发色团的组织样本的至少一个位置接收光，其中所接收的光包括衰减照明光和再发射光中的至少一个。 该方法还包括处理所接收的光的光谱以确定组织样本的至少一个位置中的每个发色团的特征。 此外，该方法包括基于所确定的特征来估计每个发色团的Z分数。 此外，该方法包括基于每个发色团的估计的Z分数将组织样本分类为多个类中的一个。

    SYSTEM AND METHOD FOR HOLDING A BIOPSY COLLECTING DEVICE
    4.
    发明申请
    SYSTEM AND METHOD FOR HOLDING A BIOPSY COLLECTING DEVICE 审中-公开
    用于保存生物收集装置的系统和方法

    公开(公告)号：US20150004641A1

    公开(公告)日：2015-01-01

    申请号：US13927807

    申请日：2013-06-26

    Applicant: General Electric Company

    Inventor： Dmitry Vladimirovich Dylov ,  Juan Pablo Cilia ,  Victor Petrovich Ostroverkhov ,  Siavash Yazdanfar ,  Stephen B. Solomon

    IPC: G01N1/30 ,  B01L3/00

    CPC classification number: G01N1/30 ,  A61B10/0233

    Abstract: An apparatus for holding a biopsy collecting device is presented. The apparatus includes a base unit configured to receive the biopsy collecting device comprising at least a needle unit and an activator unit, wherein the needle unit comprises a biopsy specimen. The apparatus further includes a fastening unit disposed at a first end of the base unit and configured to fasten at least a first portion of the needle unit to the base unit. Also, the apparatus includes a holding unit disposed at a second end of the base unit and configured to attach the activator unit of the biopsy collecting device to the base unit.

    Abstract translation: 提出了一种用于保持活检收集装置的装置。 所述装置包括基本单元，其被配置为接收包括至少针单元和活化单元的活检收集装置，其中所述针单元包括活检样本。 该装置还包括紧固单元，该紧固单元设置在基座单元的第一端，并被配置为将针单元的至少第一部分固定到基座单元。 此外，该装置还包括一个保持单元，该保持单元设置在基座单元的第二端，并被配置成将活检收集装置的活化单元附着到基座单元。

    QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING
    5.
    发明申请
    QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING 有权
    用于无标记高对比度细胞成像的定量相显微镜

    公开(公告)号：US20130286400A1

    公开(公告)日：2013-10-31

    申请号：US13663069

    申请日：2012-10-29

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Evgenia Mikhailovna Kim ,  Siavash Yazdanfar ,  Dmitry Vladimirovich Dylov

    IPC: G01B9/02

    CPC classification number: G01B9/0209 ,  G01B9/04 ,  G01B11/0675 ,  G01N21/45 ,  G02B21/14

    Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

    Abstract translation: 本文描述的系统和方法使用多个相差图像，其在由样品衍射的光和不被样品衍射的光之间具有各种相对相移，以产生定量相位图像。 所产生的定量相图可能具有足够的对比度，用于细胞体和细胞核的无标记自动分割。

    QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING USING FREQUENCY DOMAIN PHASE SHIFT
    6.
    发明申请
    QUANTITATIVE PHASE MICROSCOPY FOR LABEL-FREE HIGH-CONTRAST CELL IMAGING USING FREQUENCY DOMAIN PHASE SHIFT 审中-公开
    使用频域相移的无标度高对比度细胞成像的定量相位显微镜

    公开(公告)号：US20130162800A1

    公开(公告)日：2013-06-27

    申请号：US13663043

    申请日：2012-10-29

    Applicant: GENERAL ELECTRIC COMPANY

    Inventor： Evgenia Mikhailovna Kim ,  William Albert Challener ,  Dmitry Vladimirovich Dylov

    IPC: H04N7/18

    CPC classification number: G02B21/14

    Abstract: Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

    Abstract translation: 本文描述的一些系统包括频率相关相位板，用于产生每个来自不同频率范围的样品的多个相位对比图像，用于由被样品干涉的未衍射的光形成的光的频率范围的每个相位对比度图像 具有频率相关基准的相对于相位板相对相移的光。 在一些实施例中，多个相位对比图像可用于产生样本的定量相位图像。 相位对比图像或产生的定量相位图像可以具有足够的对比度，用于无标记的细胞体和核的自动分割。

    SYSTEM AND METHOD FOR ALIGNING A BIOPSY COLLECTING DEVICE
    10.
    发明申请
    SYSTEM AND METHOD FOR ALIGNING A BIOPSY COLLECTING DEVICE 有权
    用于校正生物收集装置的系统和方法

    公开(公告)号：US20150002845A1

    公开(公告)日：2015-01-01

    申请号：US13927683

    申请日：2013-06-26

    Applicant: General Electric Company

    Inventor： Victor Petrovich Ostroverkhov ,  Dmitry Vladimirovich Dylov ,  Siavash Yazdanfar ,  Stephen B. Solomon

    IPC: G01B11/14 ,  A61B10/02

    CPC classification number: A61B10/02 ,  G01B11/002 ,  G01J3/00 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/6417

    Abstract: A spectroscopy system for auto-aligning a biopsy collecting device is presented. The spectroscopy system includes an illumination subsystem configured to emit an illumination light towards the biopsy collecting device, whereas the biopsy collecting device includes an activator unit and a needle unit and wherein the needle unit includes a cannula and a stylet having a biopsy specimen. Also, the spectroscopy system includes a fixation subsystem capable of holding the biopsy collecting device and configured to place the needle unit comprising the biopsy specimen across the illumination light. Further, the spectroscopy system includes a detection subsystem configured to receive a light comprising at least one of an attenuated illumination light and a re-emitted light from the needle unit. In addition, the detection subsystem is configured to send a control signal to align the needle unit at a predetermined position in the spectroscopy system based on the received light.

    Abstract translation: 提出了一种用于自动对准活检收集装置的光谱系统。 光谱系统包括被配置为朝向活检收集装置发射照明光的照明子系统，而活检收集装置包括激活器单元和针单元，并且其中针单元包括插管和具有活检样本的探针。 此外，光谱系统包括固定子系统，其能够保持活检收集装置并且构造成将包括活检标本的针单元放置在照明光上。 此外，光谱系统包括被配置为接收包括衰减照明光和来自针单元的再发射光中的至少一种的光的检测子系统。 此外，检测子系统被配置为发送控制信号，以根据所接收的光将针单元对准在光谱系统中的预定位置。

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