公开(公告)号：US12264173B2

公开(公告)日：2025-04-01

申请号：US18354362

申请日：2023-07-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory F. Chin ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Dustin S. Siegel ,  Hai Yang

IPC: A61P31/14 ,  A61K31/661 ,  A61K31/675 ,  A61P31/12 ,  C07F9/6561

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US20230303599A1

公开(公告)日：2023-09-28

申请号：US18040782

申请日：2021-08-05

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Petr Jansa ,  Devan Naduthambi ,  Neil H. Squires

IPC: C07F9/6561 ,  A61K45/06 ,  A61P31/18 ,  A61P31/20

CPC classification number: C07F9/65616 ,  A61K45/06 ,  A61P31/18 ,  A61P31/20

Abstract: Compounds, compositions, and method useful for treating a viral infection, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, are disclosed. In particular, prodrugs of phosphonamide nucleotide analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.

公开(公告)号：US20220081462A1

公开(公告)日：2022-03-17

申请号：US17458023

申请日：2021-08-26

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Hon C. Hui ,  Rao V. Kalla ,  Richard L. Mackman

IPC: C07H7/06 ,  A61P31/12

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts, crystalline forms, pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US12054507B2

公开(公告)日：2024-08-06

申请号：US17178156

申请日：2021-02-17

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Edward Doerffler ,  Dustin S. Siegel ,  Andrew C. Stevens ,  Tiago Vieira

IPC: A01N43/00 ,  A01N43/46 ,  A61K31/55 ,  A61P31/14 ,  A61P31/16 ,  C07D487/04 ,  C07F9/6561

CPC classification number: C07F9/6561 ,  A61P31/14 ,  A61P31/16 ,  C07D487/04

Abstract: The present disclosure provides a compound of Formula I:






which is useful in treating a variety of diseases, such as diseases caused by respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, HCV and/or HBV infections.

公开(公告)号：US20240199676A1

公开(公告)日：2024-06-20

申请号：US18174474

申请日：2023-02-24

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Michael O. Clarke ,  Deeba Ensan ,  Richard L. Mackman ,  Devan Naduthambi ,  Dustin S. Siegel

IPC: C07H7/06 ,  A61K31/706 ,  A61P31/14

CPC classification number: C07H7/06 ,  A61K31/706 ,  A61P31/14

Abstract: Antiviral compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230382940A1

公开(公告)日：2023-11-30

申请号：US18176864

申请日：2023-03-01

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Michael O. Clarke ,  Deeba Ensan ,  Rao V. Kalla ,  Richard L. Mackman ,  Devan Naduthambi ,  Dustin S. Siegel

IPC: C07H7/06 ,  A61P31/16

CPC classification number: C07H7/06 ,  A61P31/16

Abstract: Antiviral compounds and methods of using the same, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20230322813A1

公开(公告)日：2023-10-12

申请号：US18115895

申请日：2023-03-01

Applicant: Gilead Sciences, Inc.

Inventor： Byoung-Kwon Chun ,  Rao V. Kalla ,  Richard L. Mackman

IPC: C07D519/00 ,  C07F9/6561 ,  C07D487/04 ,  A61P31/14 ,  A61K45/06

CPC classification number: C07D519/00 ,  C07F9/6561 ,  C07D487/04 ,  A61P31/14 ,  A61K45/06

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US11718637B2

公开(公告)日：2023-08-08

申请号：US17207161

申请日：2021-03-19

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Petr Jansa ,  Richard L. Mackman ,  Devan Naduthambi ,  Neil H. Squires

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/16 ,  A61P31/18 ,  A61K31/7076 ,  A61K45/06 ,  C07H19/20

CPC classification number: C07H19/16 ,  A61K31/7076 ,  A61K45/06 ,  A61P31/18 ,  C07H19/20

Abstract: The present disclosure provides prodrugs of 4′-C-substituted-2-halo-2′-deoxyadenoside nucleosides, and compositions, methods, and kits thereof. Such compounds can be useful for treating viral infections including, but not limited to, human immunodeficiency virus.

公开(公告)号：US20230151043A1

公开(公告)日：2023-05-18

申请号：US18098950

申请日：2023-01-19

Applicant: Gilead Sciences, Inc.

Inventor： Elaine Bunyan ,  Byoung-Kwon Chun ,  Kassibla E. Dempah ,  Hon C. Hui ,  Rao V. Kalla ,  Richard L. Mackman

IPC: C07H7/06 ,  A61P31/12

CPC classification number: C07H7/06 ,  A61P31/12 ,  C07B2200/13

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and salts, crystalline forms, pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

公开(公告)号：US20220119426A1

公开(公告)日：2022-04-21

申请号：US17394630

申请日：2021-08-05

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Byoung-Kwon Chun ,  Michael O. Clarke ,  Petr Jansa ,  Devan Naduthambi ,  Neil H. Squires

IPC: C07F9/36

Abstract: Compounds, compositions, and method useful for treating a viral infection, such as human immunodeficiency virus (HIV) and/or hepatitis B virus (HBV) infection, are disclosed. In particular, prodrugs of phosphonamide nucleotide analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.