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公开(公告)号：US12110294B2
公开(公告)日：2024-10-08
申请号：US17243911
申请日：2021-04-29
Applicant: Gilead Sciences, Inc.
Inventor： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Hon C. Hui , Richard L. Mackman , Michael R. Mish , Scott D. Schroeder , Nathan D. Shapiro , Dustin S. Siegel , Doris T. Tang , Hai Yang
IPC: C07D487/04 , A61K45/06 , C07D519/00 , C07K16/28
CPC classification number: C07D487/04 , A61K45/06 , C07D519/00 , C07K16/2818 , C07K16/2827
Abstract: The present disclosure provides pyrimidine dione compounds of Formula I
and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.-
公开(公告)号：US20230039553A1
公开(公告)日：2023-02-09
申请号：US17243911
申请日：2021-04-29
Applicant: Gilead Sciences, Inc.
Inventor： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Hon C. Hui , Richard L. Mackman , Michael R. Mish , Scott D. Schroeder , Nathan D. Shapiro , Dustin S. Siegel , Doris T. Tang , Hai Yang
IPC: C07D487/04 , C07D519/00 , A61K45/06 , C07K16/28
Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.
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公开(公告)号：US20210292348A1
公开(公告)日：2021-09-23
申请号：US17178115
申请日：2021-02-17
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Gregory F. Chin , Michael O. Clarke , Bindu Goyal , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel
IPC: C07F9/6561 , A61K45/06
Abstract: The present disclosure describes 4′-fluoromethyl nucleosides for treating viral infections, including Dengue.
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公开(公告)号：US20210284670A1
公开(公告)日：2021-09-16
申请号：US17178463
申请日：2021-02-18
Applicant: Gilead Sciences, Inc.
Inventor： Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC: C07F9/6561 , A61P31/14
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号：US11767337B2
公开(公告)日：2023-09-26
申请号：US17178463
申请日：2021-02-18
Applicant: Gilead Sciences, Inc.
Inventor： Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC: C07F9/6561 , A61P31/14
CPC classification number: C07F9/6561 , A61P31/14
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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Patent Agency Ranking
公开(公告)号：US20230295201A1
公开(公告)日：2023-09-21
申请号：US18171950
申请日：2023-02-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Gregory F. Chin , Byoung-kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel , David Sperandio , Hai Yang , Lijun Zhang
IPC: C07F9/6561 , A61K31/706
CPC classification number: C07F9/6561 , A61K31/706
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号：US20240226130A1
公开(公告)日：2024-07-11
申请号：US18479576
申请日：2023-10-02
Applicant: Gilead Sciences, Inc.
Inventor： Michael O. Clarke , Bindu Goyal , Richard L. Mackman , Devan Naduthambi , Neil H. Squires
IPC: A61K31/7076 , A61K31/7068 , A61K31/708 , A61K45/06 , A61P31/18 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/207
CPC classification number: A61K31/7076 , A61K31/7068 , A61K31/708 , A61K45/06 , A61P31/18 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/207
Abstract: Compounds, compositions, and methods useful for treating a viral infection, such as human immunodeficiency virus (HIV) infection, are disclosed. In particular, 4′-thionucleoside analogues and methods for their preparation and use as therapeutic or prophylactic agents are disclosed.
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公开(公告)号：US20240043427A1
公开(公告)日：2024-02-08
申请号：US17997594
申请日：2021-04-29
Applicant: Gilead Sciences, Inc.
Inventor： Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Hon C. Hui , Richard L. Mackman , Michael R. Mish , Scott D. Schroeder , Nathan D. Shapiro , Dustin S. Siegel , Doris T. Tang , Hai Yang
IPC: C07D487/04 , C07D519/00 , A61K45/06 , C07K16/28
CPC classification number: C07D487/04 , C07D519/00 , C07K16/2827 , C07K16/2818 , A61K45/06
Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.
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公开(公告)号：US12264173B2
公开(公告)日：2025-04-01
申请号：US18354362
申请日：2023-07-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC: A61P31/14 , A61K31/661 , A61K31/675 , A61P31/12 , C07F9/6561
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号：US20250051375A1
公开(公告)日：2025-02-13
申请号：US18677586
申请日：2024-05-29
Applicant: Gilead Sciences, Inc.
Inventor： Gediminas J. Brizgys , Michael O’ Neil Hanrahan Clarke , Raheel Fondekar , Bindu Goyal , Luisruben P. Martinez , Bradley Thomas Reid , Nathan D. Shapiro , Doris T. Tang
IPC: C07F9/6561 , A61K31/675
Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
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