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公开(公告)号：US12161625B2
公开(公告)日：2024-12-10
申请号：US18059806
申请日：2022-11-29
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192 , A61P31/20 , C07D487/04 , C07D519/00
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US10328053B2
公开(公告)日：2019-06-25
申请号：US15686499
申请日：2017-08-25
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , A61P31/20 , A61K31/03 , A61K31/16 , C07D487/04 , C07D519/00 , A61K31/38 , A61K31/4192
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US20180161307A1
公开(公告)日：2018-06-14
申请号：US15686499
申请日：2017-08-25
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , A61K31/16 , A61K31/03 , A61K31/38 , A61K31/4192 , A61P31/20
CPC classification number: A61K31/403 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192 , A61P31/20 , C07D487/04 , C07D519/00
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US20200061024A1
公开(公告)日：2020-02-27
申请号：US16403247
申请日：2019-05-03
Applicant: GILEAD SCIENCES, INC.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , A61K31/4192 , A61K31/38 , A61K31/16 , A61K31/03 , A61P31/20 , C07D519/00 , C07D487/04
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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Patent Agency Ranking
公开(公告)号：US20180282316A1
公开(公告)日：2018-10-04
申请号：US16001832
申请日：2018-06-06
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna M. Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Andrew Lee , Ruben Martinez , Samuel E. Metobo , Michael R. Mish , Manuel Munoz , Sophia L. Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/04 , C07D453/02 , C07D417/14 , C07D471/04 , C07D413/14
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
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公开(公告)号：US20230270719A1
公开(公告)日：2023-08-31
申请号：US18059806
申请日：2022-11-29
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , C07D487/04 , C07D519/00 , A61P31/20 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192
CPC classification number: A61K31/403 , C07D487/04 , C07D519/00 , A61P31/20 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US20230148157A1
公开(公告)日：2023-05-11
申请号：US17862896
申请日：2022-07-12
Applicant: Gilead Sciences, Inc.
Inventor： David Alan Gutierrez , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Philip Anthony Morganelli , Hyung-Jung Pyun
IPC: C07D487/04 , A61P31/20
CPC classification number: C07D487/04 , A61P31/20
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US11420974B2
公开(公告)日：2022-08-23
申请号：US17070236
申请日：2020-10-14
Applicant: GILEAD SCIENCES, INC.
Inventor： David Alan Gutierrez , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Philip Anthony Morganelli , Hyung-Jung Pyun
IPC: C07D487/04 , A61P31/20
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US20190292187A1
公开(公告)日：2019-09-26
申请号：US16284812
申请日：2019-02-25
Applicant: Gilead Sciences, Inc.
Inventor： David Alan Gutierrez , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Philip Anthony Morganelli , Hyung-Jung Pyun
IPC: C07D487/04 , A61P31/20
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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