公开(公告)号：US20230270719A1

公开(公告)日：2023-08-31

申请号：US18059806

申请日：2022-11-29

申请人： Gilead Sciences, Inc.

发明人： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC分类号： A61K31/403 ,  C07D487/04 ,  C07D519/00 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192

CPC分类号： A61K31/403 ,  C07D487/04 ,  C07D519/00 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192

摘要： This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US10328053B2

公开(公告)日：2019-06-25

申请号：US15686499

申请日：2017-08-25

申请人： Gilead Sciences, Inc.

发明人： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC分类号： A61K31/403 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  C07D487/04 ,  C07D519/00 ,  A61K31/38 ,  A61K31/4192

摘要： This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20180161307A1

公开(公告)日：2018-06-14

申请号：US15686499

申请日：2017-08-25

申请人： Gilead Sciences, Inc.

发明人： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC分类号： A61K31/403 ,  A61K31/16 ,  A61K31/03 ,  A61K31/38 ,  A61K31/4192 ,  A61P31/20

CPC分类号： A61K31/403 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192 ,  A61P31/20 ,  C07D487/04 ,  C07D519/00

摘要： This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20200061024A1

公开(公告)日：2020-02-27

申请号：US16403247

申请日：2019-05-03

申请人： GILEAD SCIENCES, INC.

发明人： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC分类号： A61K31/403 ,  A61K31/4192 ,  A61K31/38 ,  A61K31/16 ,  A61K31/03 ,  A61P31/20 ,  C07D519/00 ,  C07D487/04

摘要： This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20180282316A1

公开(公告)日：2018-10-04

申请号：US16001832

申请日：2018-06-06

申请人： Gilead Sciences, Inc.

发明人： Evangelos Aktoudianakis ,  Gregory Chin ,  Britton Kenneth Corkey ,  Jinfa Du ,  Kristyna M. Elbel ,  Robert H. Jiang ,  Tetsuya Kobayashi ,  Rick Andrew Lee ,  Ruben Martinez ,  Samuel E. Metobo ,  Michael R. Mish ,  Manuel Munoz ,  Sophia L. Shevick ,  David Sperandio ,  Hai Yang ,  Jeff Zablocki

IPC分类号： C07D413/04 ,  C07D453/02 ,  C07D417/14 ,  C07D471/04 ,  C07D413/14

摘要： This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.