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公开(公告)号：US11701422B2
公开(公告)日：2023-07-18
申请号：US16800384
申请日：2020-02-25
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Alessandra Vitelli , Alfredo Nicosia , Riccardo Cortese
IPC: A61K39/155 , A61K39/145 , A61K39/12 , C07K14/005 , C12N15/85 , C12N15/86 , A61K39/00
CPC classification number: A61K39/145 , A61K39/12 , A61K39/155 , C07K14/005 , C12N15/85 , C12N15/86 , A61K2039/53 , C12N2710/10343 , C12N2760/18522 , C12N2760/18534 , C12N2800/22 , C12N2840/20
Abstract: The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or variant thereof, which induces a T cell response, and a second polynucleotide encoding at least one protein, peptide or variant thereof, which induces an anti-pathogenic B cell response. The invention further relates to protein mixtures encoded by the expression system and cells comprising the expression system or the protein mixture and pharmaceutical compositions comprising the expression system or the protein mixture.
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公开(公告)号：US20240075125A1
公开(公告)日：2024-03-07
申请号：US18200421
申请日：2023-05-22
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Alessandra Vitelli , Alfredo Nicosia , Riccardo Cortese
IPC: A61K39/145 , A61K39/12 , A61K39/155 , C07K14/005 , C12N15/85 , C12N15/86
CPC classification number: A61K39/145 , A61K39/12 , A61K39/155 , C07K14/005 , C12N15/85 , C12N15/86 , A61K2039/53
Abstract: The invention relates to an expression system comprising polynucleotides encoding proteins, wherein the expression system comprises a first polynucleotide encoding at least one protein, peptide or variant thereof, which induces a T cell response, and a second polynucleotide encoding at least one protein, peptide or variant thereof, which induces an anti-pathogenic B cell response. The invention further relates to protein mixtures encoded by the expression system and cells comprising the expression system or the protein mixture and pharmaceutical compositions comprising the expression system or the protein mixture.
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Patent Agency Ranking
公开(公告)号：US11957749B2
公开(公告)日：2024-04-16
申请号：US16772194
申请日：2018-12-14
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Virginia Ammendola , Babak Bayat , Clarisse Lorin , Ventzislav Bojidarov Vassilev , Alessandra Vitelli
CPC classification number: A61K39/292 , A61K39/39 , A61P31/20 , C07K14/005 , C12N7/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C07K2319/40 , C12N2710/10343 , C12N2710/24143 , C12N2730/10122 , C12N2730/10134
Abstract: The present invention relates to immunogenic compositions and combinations thereof which may find use in immunisation regimens for the treatment of chronic hepatitis B. An immunogenic composition comprises a replication-defective chimpanzee adenoviral (ChAd) vector comprising polynucleotides encoding HBs, HBc human invariant chain (hIi) fused to the HBc. Another immunogenic composition comprises a Modified Vaccinia Virus Ankara (MVA) vector comprising polynucleotides encoding HBs and HBc. Another immunogenic composition comprises recombinant HBs, C-terminal truncated recombinant HBc and an adjuvant containing MPL and QS-21.
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公开(公告)号：US11571472B2
公开(公告)日：2023-02-07
申请号：US15318490
申请日：2015-06-12
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Ann-Muriel Steff , Jean-Francois Toussaint , Alessandra Vitelli
IPC: A61K39/155 , A61K39/235 , A61K39/12 , A61K39/00
Abstract: Immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent administration are provided, as well as methods for making and for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.
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5.发明公开公开(公告)号：US20240091338A1
公开(公告)日：2024-03-21
申请号：US18115556
申请日：2023-02-28
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Alfredo Nicosia , Ricardo Cortese , Alessandra Vitelli
IPC: A61K39/155 , A61K39/12 , A61K39/235 , A61K39/275
CPC classification number: A61K39/155 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/545
Abstract: The present invention relates to administration regimens which are particularly suited for vaccine composition comprising polynucleotides which encode immunogenic polypeptides. Said administration regimens involve the repeated administration of a vaccine composition and enhance the immune response against the immunogenic polypeptide.
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公开(公告)号：US11268108B2
公开(公告)日：2022-03-08
申请号：US16756376
申请日：2018-10-16
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Virginia Ammendola , Stefano Colloca , Alessandra Vitelli
Abstract: Replication competent simian adenoviral vectors are provided for the delivery of exogenous immunogens. Vectors of the invention demonstrate superior replication and expression of exogenous immunogens. They are useful as prophylactic and therapeutic vaccines as well as in gene therapy.
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公开(公告)号：US11254711B2
公开(公告)日：2022-02-22
申请号：US15735872
申请日：2016-06-10
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Virginia Ammendola , Stefano Colloca , Riccardo Cortese , Fabiana Grazioli , Alfredo Nicosia , Alessandra Vitelli
IPC: C07K14/005 , C12N15/86 , C07K14/075 , A61K39/12 , A61K39/21 , C07K14/75 , C12N15/861 , A61K39/155 , C12N7/00 , A61K39/00
Abstract: There is provided inter alia an isolated polynucleotide, wherein the polynucleotide encodes a polypeptide selected from the group consisting of:
(a) a polypeptide having the amino acid sequence according to SEQ ID NO: 1,
(b) a functional derivative of a polypeptide having the amino acid sequence according to SEQ ID NO: 1, wherein the functional derivative has an amino acid sequence which is at least 80% identical over its entire length to the amino acid sequence of SEQ ID NO: 1, and (c) a polypeptide having the amino acid sequence according to SEQ ID NO: 3.
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