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公开(公告)号：US20130172985A1
公开(公告)日：2013-07-04
申请号：US13522032
申请日：2011-01-13
IPC分类号： C07K14/435 , A61F2/06 , A61N5/06
CPC分类号： C07K14/435 , A61F2/06 , A61K41/0042 , A61L27/222 , A61L27/38 , A61L27/48 , A61L27/52 , A61N5/062 , C07K14/78 , C08H1/06 , C08J3/246 , C08J2305/08 , C08J2389/00 , C08K5/0025 , C08L89/06 , C08L2312/00 , C08L89/00
摘要： Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
摘要翻译： 本文描述的是修饰明胶或其药学上可接受的盐或酯，其包含共价键合到明胶上的至少一种可光化交联的基团。 修饰的明胶可用于生产最终可用于生产三维工程生物构建体的复合材料。 复合材料是改性明胶与至少一种可光化交联的大分子之间的聚合产物。 本文还描述了制备改性明胶的方法。
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公开(公告)号：US20100330143A1
公开(公告)日：2010-12-30
申请号：US12764466
申请日：2010-04-21
IPC分类号： C07K14/78 , C08B37/00 , C08G63/91 , C08F120/10 , A61K31/728 , A61K38/39 , A61K31/74 , A61F2/00 , B05D5/00 , C12Q1/02 , C12N5/073
CPC分类号： C08B37/0072 , A61K31/728 , A61K31/74 , C08B15/10 , C08B37/003 , C08B37/0045 , C08B37/0069 , C08B37/0075 , C08B37/0084 , C08G63/91 , C08L2203/02 , C12N5/0068 , C12N2533/80 , C12N2537/10
摘要： Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods described herein permit the cross-linking of a variety of different thiolated macromolecules with one another. The composites described herein have a variety of biomedical and pharmaceutical applications, which are also described herein.
摘要翻译： 本文描述的是通过使第一硫醇化大分子与至少一种具有至少一个硫醇反应性亲电官能团的化合物反应制备的复合材料。 本文描述的方法允许各种不同硫醇化的大分子彼此交联。 本文描述的复合材料具有各种生物医学和药物应用，其也在本文中描述。
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3.发明授权公开(公告)号：US09938502B2
公开(公告)日：2018-04-10
申请号：US13882429
申请日：2011-11-04
申请人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
发明人： Yuanyuan Zhang , Shay Soker , Anthony Atala , Aleksander Skardal
CPC分类号： C12N5/0671 , C12N5/0068 , C12N2513/00 , C12N2533/54 , C12N2533/80 , C12N2533/90
摘要： The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a tissue-specific extracellular matrix wherein the matrix provides a substrate for which the cultured cell originated from. The tissue-specific extracellular matrix can further comprise a component of a whole tissue-specific homogenate.
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