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1.发明申请COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF 审中-公开具有TRPV4活性的化合物，组合物及其相关方法公开(公告)号：US20130303539A1
公开(公告)日：2013-11-14
申请号：US13841790
申请日：2013-03-15
申请人： David Krizaj , Glenn D. Prestwich , Peter Barabas , Yong Xu , Daniel Ryskamp
发明人： David Krizaj , Glenn D. Prestwich , Peter Barabas , Yong Xu , Daniel Ryskamp
IPC分类号： C07D207/34 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/5377 , A61K45/06 , C07D207/34 , C07D209/42 , C07D471/04
摘要： Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed.
摘要翻译： 提供了可用于治疗眼部疾病的化合物，组合物和方法。 特别地，公开了TRPV4的拮抗剂，它们的合成，其药物组合物和治疗眼部疾病如青光眼的方法。
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公开(公告)号：US20130172985A1
公开(公告)日：2013-07-04
申请号：US13522032
申请日：2011-01-13
IPC分类号： C07K14/435 , A61F2/06 , A61N5/06
CPC分类号： C07K14/435 , A61F2/06 , A61K41/0042 , A61L27/222 , A61L27/38 , A61L27/48 , A61L27/52 , A61N5/062 , C07K14/78 , C08H1/06 , C08J3/246 , C08J2305/08 , C08J2389/00 , C08K5/0025 , C08L89/06 , C08L2312/00 , C08L89/00
摘要： Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
摘要翻译： 本文描述的是修饰明胶或其药学上可接受的盐或酯，其包含共价键合到明胶上的至少一种可光化交联的基团。 修饰的明胶可用于生产最终可用于生产三维工程生物构建体的复合材料。 复合材料是改性明胶与至少一种可光化交联的大分子之间的聚合产物。 本文还描述了制备改性明胶的方法。
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3.发明授权Alkylated semi synthetic glycosaminoglycosan ethers, and methods for making and using thereof 有权烷基化半合成糖胺聚糖醚，及其制备和使用方法公开(公告)号：US08329673B2
公开(公告)日：2012-12-11
申请号：US13304292
申请日：2011-11-23
IPC分类号： A61K31/728 , A61K9/00 , C08B37/08 , A61P27/02 , A61P27/04
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment.
摘要翻译： 本文所述的是烷基化和半合成的糖胺聚糖醚，在本文中称为SAGE。 还描述了硫酸化和烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括用于眼部或眼部治疗。
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公开(公告)号：US07981871B2
公开(公告)日：2011-07-19
申请号：US10581571
申请日：2004-12-06
申请人： Glenn D. Prestwich , Xiao Zheng Shu , Yanchun Liu
发明人： Glenn D. Prestwich , Xiao Zheng Shu , Yanchun Liu
IPC分类号： A01N43/04 , A01N25/00 , A61K31/715 , A61K31/727 , A61K47/00 , A61K9/14 , A61K9/50 , C07H5/04 , C07H5/06 , C08B37/00 , C08B37/10
CPC分类号： C08B37/0063 , A61L27/20 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08H1/06 , C08J3/075 , C08J2305/08 , C08L5/08 , C12N5/0068 , C12N2533/54 , C12N2533/80
摘要： Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.
摘要翻译： 本文描述的是已经通过引入至少一个酰肼反应性基团和/或氨氧基反应性基团来促进交联而被修饰的化合物，以及制备和使用它们用于无瘢痕伤口愈合的方法，用于递送 生物活性剂或活细胞，用于防止外科手术之后的粘连或用于骨和软骨修复。 大分子可以是寡核苷酸，碳酸，多肽，脂质，糖蛋白，糖脂，多糖，蛋白质或合成聚合物，优选糖胺聚糖如透明质酸。
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公开(公告)号：US20100330143A1
公开(公告)日：2010-12-30
申请号：US12764466
申请日：2010-04-21
IPC分类号： C07K14/78 , C08B37/00 , C08G63/91 , C08F120/10 , A61K31/728 , A61K38/39 , A61K31/74 , A61F2/00 , B05D5/00 , C12Q1/02 , C12N5/073
CPC分类号： C08B37/0072 , A61K31/728 , A61K31/74 , C08B15/10 , C08B37/003 , C08B37/0045 , C08B37/0069 , C08B37/0075 , C08B37/0084 , C08G63/91 , C08L2203/02 , C12N5/0068 , C12N2533/80 , C12N2537/10
摘要： Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods described herein permit the cross-linking of a variety of different thiolated macromolecules with one another. The composites described herein have a variety of biomedical and pharmaceutical applications, which are also described herein.
摘要翻译： 本文描述的是通过使第一硫醇化大分子与至少一种具有至少一个硫醇反应性亲电官能团的化合物反应制备的复合材料。 本文描述的方法允许各种不同硫醇化的大分子彼此交联。 本文描述的复合材料具有各种生物医学和药物应用，其也在本文中描述。
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公开(公告)号：US5652347A
公开(公告)日：1997-07-29
申请号：US484567
申请日：1995-06-07
申请人： Tara Pouyani , Glenn D. Prestwich
发明人： Tara Pouyani , Glenn D. Prestwich
CPC分类号： C08B37/0072 , Y10S514/944 , Y10S514/95 , Y10S514/964
摘要： Hyaluronate functionalized with dihydrazide is provided and may be cross-linked. A method for producing hyaluronate functionalized with dihydrazide includes mixing hyaluronate and dihydrazide in aqueous solution, then adding carbodiimide so that the hyaluronate and dihydrazide react to form functionalized hyaluronate.
摘要翻译： 提供用二酰肼官能化的透明质酸盐并且可以是交联的。 用二酰肼官能化的透明质酸盐的制备方法包括将透明质酸盐和二酰肼在水溶液中混合，然后加入碳二亚胺使得透明质酸盐和二酰肼反应形成官能化的透明质酸盐。
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公开(公告)号：US08859523B2
公开(公告)日：2014-10-14
申请号：US12234445
申请日：2008-09-19
申请人： Glenn D. Prestwich , Xiao Zheng Shu , Yi Luo , Kelly R. Kirker , Yanchun Liu
发明人： Glenn D. Prestwich , Xiao Zheng Shu , Yi Luo , Kelly R. Kirker , Yanchun Liu
IPC分类号： A01N43/04 , A61K31/715 , A61K31/727 , A61K38/39 , A61K47/48 , A61K9/14 , C07K14/78 , A61K8/73 , C07K1/107
CPC分类号： A61K47/4823 , A61K47/61 , C07K1/1072 , C07K14/78
摘要： Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at least one thiol-reactive compound.
摘要翻译： 本文描述了可用于许多处理的交联化合物。 本文描述的是通过（1）两种或多种硫醇化合物的氧化偶联或（2）通过至少一种硫醇化合物与至少一种硫醇反应性化合物之间的反应制备交联化合物的方法。
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8.发明申请HYDROGELS CROSSLINKED WITH GOLD NANOPARTICLES AND METHODS OF MAKING AND USING THEREOF 审中-公开与金纳米颗粒交联的水凝胶及其制备和使用方法公开(公告)号：US20110280914A1
公开(公告)日：2011-11-17
申请号：US13146564
申请日：2009-12-17
IPC分类号： A61K9/00 , C07K14/435 , A61K47/36 , A61K47/38 , A61K47/42 , A61K35/12 , A61K35/30 , A61K35/34 , A61K35/407 , A61K35/36 , A61K35/14 , A61K35/39 , C12N5/071 , C12N5/077 , C12N5/0793 , C12N5/078 , C12Q1/02 , C12P21/08 , C12P21/00 , C07H23/00 , B82Y5/00
CPC分类号： G01N33/585 , A61L27/38 , A61L27/446 , B22F1/0062 , B22F1/0096 , B82Y5/00 , C12N5/0068 , C12N2533/10 , C12N2533/80 , G01N33/532 , G01N2400/10
摘要： Described herein are composites useful in tissue and organ engineering. In one aspect, the composite comprises the reaction product between a macromolecule comprising at least one thiol group and a gold nanoparticle. The thiolated macro-molecule crosslinks with the gold nanoparticle to produce a composite that is useful in anchoring cells. The composites can be used to form multi-layer 3-D structures, where the cells in each layer can aggregate and fuse with one another to form tissues and organs.
摘要翻译： 这里描述的是在组织和器官工程中有用的复合材料。 在一个方面，复合物包含包含至少一个硫醇基的大分子和金纳米颗粒之间的反应产物。 硫醇化的大分子与金纳米颗粒交联以产生可用于锚定细胞的复合物。 复合材料可用于形成多层3-D结构，其中每层中的细胞可以彼此聚集并融合以形成组织和器官。
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9.发明申请ALKYLATED SEMI SYNTHETIC GLYCOSAMINOGLYCOSAN ETHERS, AND METHODS FOR MAKING AND USING THEREOF 有权烷基半胱氨酸合成谷氨酰胺聚糖酯及其制备及使用方法公开(公告)号：US20110082104A1
公开(公告)日：2011-04-07
申请号：US12870774
申请日：2010-08-27
IPC分类号： A61K31/726 , C08B37/08 , A61P17/02 , A61P17/00 , A61P17/06 , A61P17/10 , A61P17/12 , A61P17/08
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders.
摘要翻译： 本文描述的是合成烷基化和半合成的糖胺聚糖醚，本文称为“SAGE”。还描述了硫酸化烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括伤口愈合，药物递送以及治疗许多炎性疾病和皮肤病症。
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10.发明授权Alkylated semi-synthetic glycosaminoglycosan ethers, and methods of making and using thereof 有权烷基化半合成糖胺聚糖醚，及其制备和使用方法公开(公告)号：US07855187B1
公开(公告)日：2010-12-21
申请号：US12870763
申请日：2010-08-27
IPC分类号： A61K31/715
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders.
摘要翻译： 本文描述的是合成烷基化和半合成的糖胺聚糖醚，本文称为“SAGE”。还描述了硫酸化烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括伤口愈合，药物递送以及治疗许多炎性疾病和皮肤病症。
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