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公开(公告)号：US20050059168A1
公开(公告)日：2005-03-17
申请号：US10666333
申请日：2003-09-17
Applicant: Guillermo Bazan , Bin Liu
Inventor： Guillermo Bazan , Bin Liu
IPC: C08G61/02 , C08G61/10 , C08G61/12 , C08G73/02 , C08G73/08 , H01B1/12 , C08G63/48 , C08G63/91 , G01N33/543
CPC classification number: H01B1/122 , C08G61/02 , C08G61/10 , C08G61/123 , C08G61/126 , C08G73/02 , C08G73/08 , C40B40/04
Abstract: Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the ability of the polymers to form extended-rod structures is provided. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Abstract translation: 提供涉及阳离子共轭构象柔性聚合物的方法，组合物和制品。 提供了一种用于合成阳离子水溶性聚合物的方法，所述聚合物具有沿聚合物主链结构的连接，其破坏聚合物形成延伸棒结构的能力。 这种聚合物可用于制造新的光电器件和开发高效生物传感器。 本发明还涉及这些聚合物在测定方法中的应用。
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2.发明申请Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays 有权阳离子共轭聚合物适用于在均相和固相测定中的链特异性多核苷酸检测公开(公告)号：US20060183140A1
公开(公告)日：2006-08-17
申请号：US11329495
申请日：2006-01-10
Applicant: Guillermo Bazan , Bin Liu
Inventor： Guillermo Bazan , Bin Liu
CPC classification number: C08G61/02 , C08G61/122 , C08G61/123 , C12Q1/6818 , C12Q1/6837 , G01N21/6428 , G01N21/6452 , G01N2021/6419 , G01N2021/6439 , C12Q2563/131 , C12Q2537/119 , C12Q2525/107
Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.
Abstract translation: 本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。
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公开(公告)号：US20060054886A1
公开(公告)日：2006-03-16
申请号：US11221026
申请日：2005-09-06
Applicant: Guillermo Bazan , Alan Heeger , Parameswar Iyer , Bin Liu
Inventor： Guillermo Bazan , Alan Heeger , Parameswar Iyer , Bin Liu
CPC classification number: C08G73/0694 , C08G61/124 , C08G61/126 , C08G73/00 , C08G73/02 , C08G73/08 , H01L51/0034 , H01L51/0035 , H01L51/0036 , H01L51/0037 , H01L51/0038 , H01L51/0039 , H01L51/0042 , H01L51/0043 , H01L51/007 , H01L51/0085 , H01L51/5048 , H01L51/56
Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymers may desirably comprise monomers which alter their conductivity properties. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.
Abstract translation: 提供涉及可溶性共轭聚合物的方法，组合物和制品。 共轭聚合物具有足够的极性取代基密度，使其可溶于极性介质，例如水和/或甲醇。 共轭聚合物可以理想地包含改变其导电性能的单体。 这些聚合物的不同溶解度特性允许它们以多层形式沉积在其它共轭聚合物中。 还提供了包含具有不同溶解度特性的多层共轭聚合物的制品。 本文进一步描述本发明的实施例。
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4.发明申请Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores 有权使用光采收多色谱探测和分析多核苷酸结合蛋白相互作用的方法和组合物公开(公告)号：US20050003386A1
公开(公告)日：2005-01-06
申请号：US10779412
申请日：2004-02-13
Applicant: Guillermo Bazan , Shu Wang , Bin Liu
Inventor： Guillermo Bazan , Shu Wang , Bin Liu
CPC classification number: C12Q1/6818 , Y10T436/143333 , C12Q2565/101
Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PBP that can bind to the target polynucleotide. The sensor PBP comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
Abstract translation: 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将怀疑含有靶多核苷酸的样品与聚阳离子多重色素和可与靶多核苷酸结合的传感器PBP接触。 传感器PBP包括信号发色团，以吸收来自激发的多色素的能量并在靶多核苷酸的存在下发光。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。
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公开(公告)号：US20070088130A1
公开(公告)日：2007-04-19
申请号：US11561893
申请日：2006-11-21
Applicant: Guillermo Bazan , Bin Liu
Inventor： Guillermo Bazan , Bin Liu
IPC: C08F297/02
CPC classification number: H01B1/122 , C08G61/02 , C08G61/10 , C08G61/123 , C08G61/126 , C08G73/02 , C08G73/08 , C40B40/04
Abstract: Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the ability of the polymers to form extended-rod structures is provided. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Abstract translation: 提供涉及阳离子共轭构象柔性聚合物的方法，组合物和制品。 提供了一种用于合成阳离子水溶性聚合物的方法，所述聚合物具有沿聚合物主链结构的连接，其破坏聚合物形成延伸棒结构的能力。 这种聚合物可用于制造新的光电器件和开发高效生物传感器。 本发明还涉及这些聚合物在测定方法中的应用。
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Patent Agency Ranking
公开(公告)号：US20060079647A1
公开(公告)日：2006-04-13
申请号：US11221123
申请日：2005-09-06
Applicant: Guillermo Bazan , Bin Liu
Inventor： Guillermo Bazan , Bin Liu
IPC: C08F297/02
CPC classification number: C08G61/123 , C08F8/44 , C08F257/00 , C08F279/02 , C08F287/00 , C08F289/00 , C08F291/00 , C08G61/02 , C08G61/124 , C08G61/125 , C08G61/126 , C08G73/00 , C08G73/06 , C08G73/08 , C08L51/006 , C08L51/04 , H01L51/0034 , H01L51/0035 , H01L51/0036 , H01L51/0037 , H01L51/0038 , H01L51/0039 , H01L51/0043 , H01L51/5048 , C08L2666/02
Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.
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公开(公告)号：US20070274357A1
公开(公告)日：2007-11-29
申请号：US10595179
申请日：2004-09-17
Applicant: Guillermo Bazan , Bin Liu , Xiong Gong , Alan Heeger , Wanll Ma , Parameswar Iyer
Inventor： Guillermo Bazan , Bin Liu , Xiong Gong , Alan Heeger , Wanll Ma , Parameswar Iyer
CPC classification number: H01L51/0003 , C08G61/02 , C08G61/10 , C08G61/123 , C08G61/126 , C08G73/02 , C08G73/08 , H01B1/127 , H01B1/128 , H01L51/0007 , H01L51/0036 , H01L51/0038 , H01L51/0039 , H01L51/0043 , H01L51/56 , H01S3/168 , Y10T428/31504
Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.
Abstract translation: 提供涉及可溶性共轭聚合物的方法，组合物和制品。 共轭聚合物具有足够的极性取代基密度，使其可溶于极性介质，例如水和/或甲醇。 共轭聚合物可以理想地包括改变其导电性能的单体。 在一些实施方案中，本发明人提供了包含增溶基团和导电基团的阳离子共轭聚合物（CCPs），导致可溶于极性介质的导电共轭聚合物。 这些聚合物的不同溶解度特性允许它们以多层形式沉积在其它共轭聚合物中。 还提供了包含具有不同溶解度特性的多层共轭聚合物的制品。 本文进一步描述本发明的实施例。
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公开(公告)号：US20060247384A9
公开(公告)日：2006-11-02
申请号：US11221123
申请日：2005-09-06
Applicant: Guillermo Bazan , Bin Liu
Inventor： Guillermo Bazan , Bin Liu
IPC: C08F297/02
CPC classification number: C08G61/123 , C08F8/44 , C08F257/00 , C08F279/02 , C08F287/00 , C08F289/00 , C08F291/00 , C08G61/02 , C08G61/124 , C08G61/125 , C08G61/126 , C08G73/00 , C08G73/06 , C08G73/08 , C08L51/006 , C08L51/04 , H01L51/0034 , H01L51/0035 , H01L51/0036 , H01L51/0037 , H01L51/0038 , H01L51/0039 , H01L51/0043 , H01L51/5048 , C08L2666/02
Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.
Abstract translation: 提供涉及可溶性共轭聚合物的方法，组合物和制品。 共轭聚合物具有足够的极性取代基密度，使其可溶于极性介质，例如水和/或甲醇。 共轭聚合物可以理想地包括改变其导电性能的单体。 在一些实施方案中，本发明人提供了包含增溶基团和导电基团的阳离子共轭聚合物（CCPs），导致可溶于极性介质的导电共轭聚合物。 这些聚合物的不同溶解度特性允许它们以多层形式沉积在其它共轭聚合物中。 还提供了包含具有不同溶解度特性的多层共轭聚合物的制品。 本文进一步描述本发明的实施例。
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9.发明申请Methods and articles for strand-specific polynucleotide detection with cationic multichromophores 有权用阳离子多重色谱法检测链特异性多核苷酸的方法和文章公开(公告)号：US20060216734A1
公开(公告)日：2006-09-28
申请号：US11329861
申请日：2006-01-10
Applicant: Guillermo Bazan , Bin Liu
Inventor： Guillermo Bazan , Bin Liu
CPC classification number: C12Q1/6818 , C12Q2563/119 , C12Q2565/101 , C12Q2565/519 , C12Q2565/607 , C12Q2523/313
Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.
Abstract translation: 本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。
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公开(公告)号：US20060204984A1
公开(公告)日：2006-09-14
申请号：US11344942
申请日：2006-01-31
Applicant: Guillermo Bazan , Bin Liu
Inventor： Guillermo Bazan , Bin Liu
CPC classification number: G01N21/6486 , C08G61/02 , C08G61/123 , C12Q1/6818 , C12Q1/6825 , G01N33/542 , G01N33/54373 , Y10T436/143333 , C12Q2565/113 , C12Q2563/173 , C12Q2565/101
Abstract: This invention relates to an aggregation sensor useful for the detection and analysis of aggregants in a sample, and methods, articles and compositions relating to such a sensor. The sensor comprises first and second optically active units, where energy may be transferred from an excited state of the first optically active unit to the second optically active unit. The second optically active unit is present in a lesser amount, but its relative concentration is increased upon aggregation, increasing its absorption of energy from the first optically active units. This increase in energy transfer can be detected in variety of formats to produce an aggregation sensing system for various aggregants, including for quantitation. Other variations of the inventions are described further herein.
Abstract translation: 本发明涉及可用于检测和分析样品中的聚集体的聚集传感器，以及与这种传感器相关的方法，制品和组合物。 传感器包括第一和第二光学有源单元，其中能量可以从第一光学活性单元的激发状态转移到第二光学活性单元。 第二光学活性单元以较小的量存在，但是其聚集时其相对浓度增加，从而增加其从第一光学活性单元的能量吸收。 可以以各种格式检测能量转移的这种增加，以产生用于各种聚合物的聚集感测系统，包括用于定量。 本文进一步描述了本发明的其它变型。
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