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    Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores
    1.
    发明申请
    Methods and compositions for detection and analysis of polynucleotide-binding protein interactions using light harvesting multichromophores 有权
    使用光采收多色谱探测和分析多核苷酸结合蛋白相互作用的方法和组合物

    公开(公告)号：US20050003386A1

    公开(公告)日：2005-01-06

    申请号：US10779412

    申请日：2004-02-13

    申请人： Guillermo Bazan ,  Shu Wang ,  Bin Liu

    发明人： Guillermo Bazan ,  Shu Wang ,  Bin Liu

    IPC分类号： C07F5/02 ,  C07H21/00 ,  C07H21/04 ,  C08G63/48 ,  C08G63/91 ,  C12Q1/68 ,  G01N20060101

    CPC分类号： C12Q1/6818 ,  Y10T436/143333 ,  C12Q2565/101

    摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PBP that can bind to the target polynucleotide. The sensor PBP comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.

    摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将怀疑含有靶多核苷酸的样品与聚阳离子多重色素和可与靶多核苷酸结合的传感器PBP接触。 传感器PBP包括信号发色团，以吸收来自激发的多色素的能量并在靶多核苷酸的存在下发光。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。

    Conformationally Flexible Cationic Conjugated Polymers
    2.
    发明申请
    Conformationally Flexible Cationic Conjugated Polymers 有权
    构象柔性阳离子共轭聚合物

    公开(公告)号：US20070088130A1

    公开(公告)日：2007-04-19

    申请号：US11561893

    申请日：2006-11-21

    申请人： Guillermo Bazan ,  Bin Liu

    发明人： Guillermo Bazan ,  Bin Liu

    IPC分类号： C08F297/02

    CPC分类号： H01B1/122 ,  C08G61/02 ,  C08G61/10 ,  C08G61/123 ,  C08G61/126 ,  C08G73/02 ,  C08G73/08 ,  C40B40/04

    摘要： Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the ability of the polymers to form extended-rod structures is provided. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

    摘要翻译： 提供涉及阳离子共轭构象柔性聚合物的方法，组合物和制品。 提供了一种用于合成阳离子水溶性聚合物的方法，所述聚合物具有沿聚合物主链结构的连接，其破坏聚合物形成延伸棒结构的能力。 这种聚合物可用于制造新的光电器件和开发高效生物传感器。 本发明还涉及这些聚合物在测定方法中的应用。

    Conformationally flexible cationic conjugated polymers
    4.
    发明申请
    Conformationally flexible cationic conjugated polymers 有权
    构象柔性阳离子共轭聚合物

    公开(公告)号：US20050059168A1

    公开(公告)日：2005-03-17

    申请号：US10666333

    申请日：2003-09-17

    申请人： Guillermo Bazan ,  Bin Liu

    发明人： Guillermo Bazan ,  Bin Liu

    IPC分类号： C08G61/02 ,  C08G61/10 ,  C08G61/12 ,  C08G73/02 ,  C08G73/08 ,  H01B1/12 ,  C08G63/48 ,  C08G63/91 ,  G01N33/543

    CPC分类号： H01B1/122 ,  C08G61/02 ,  C08G61/10 ,  C08G61/123 ,  C08G61/126 ,  C08G73/02 ,  C08G73/08 ,  C40B40/04

    摘要： Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the ability of the polymers to form extended-rod structures is provided. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

    摘要翻译： 提供涉及阳离子共轭构象柔性聚合物的方法，组合物和制品。 提供了一种用于合成阳离子水溶性聚合物的方法，所述聚合物具有沿聚合物主链结构的连接，其破坏聚合物形成延伸棒结构的能力。 这种聚合物可用于制造新的光电器件和开发高效生物传感器。 本发明还涉及这些聚合物在测定方法中的应用。

    Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays
    5.
    发明申请
    Cationic conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays 有权
    阳离子共轭聚合物适用于在均相和固相测定中的链特异性多核苷酸检测

    公开(公告)号：US20060183140A1

    公开(公告)日：2006-08-17

    申请号：US11329495

    申请日：2006-01-10

    申请人： Guillermo Bazan ,  Bin Liu

    发明人： Guillermo Bazan ,  Bin Liu

    IPC分类号： C12Q1/68 ,  C08G63/91

    CPC分类号： C08G61/02 ,  C08G61/122 ,  C08G61/123 ,  C12Q1/6818 ,  C12Q1/6837 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6439 ,  C12Q2563/131 ,  C12Q2537/119 ,  C12Q2525/107

    摘要： The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

    摘要翻译： 本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

    COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES
    7.
    发明申请
    COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDES USING LIGHT HARVESTING MULTICHROMOPHORES 有权
    使用光收集多色素检测和分析多核苷酸的组合物

    公开(公告)号：US20080064042A1

    公开(公告)日：2008-03-13

    申请号：US11854365

    申请日：2007-09-12

    申请人： Guillermo Bazan ,  Brent Gaylord ,  Shu Wang

    发明人： Guillermo Bazan ,  Brent Gaylord ,  Shu Wang

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6834 ,  C12Q1/6813 ,  C12Q1/6818 ,  C12Q1/6825 ,  Y10T436/143333 ,  C12Q2565/107 ,  C12Q2563/107 ,  C12Q2523/313

    摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from the excited multichromophore and increase emission in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.

    摘要翻译： 提供了用于测定靶多核苷酸样品的方法，组合物和制品。 将涉及含有靶多核苷酸的样品与聚阳离子多重色素和与靶多核苷酸互补的传感器多核苷酸接触。 所述传感器多核苷酸包含用于从所述激发的多色素载体接收能量的信号发色团，并且在靶多核苷酸的存在下增加发射。 该方法可以多路复用形式使用。 还提供了包含用于执行这些方法的试剂的试剂盒。

    Multilayer polymer light-emitting diodes for solid state lighting applications
    8.
    发明申请
    Multilayer polymer light-emitting diodes for solid state lighting applications 有权
    用于固态照明应用的多层聚合物发光二极管

    公开(公告)号：US20060202616A1

    公开(公告)日：2006-09-14

    申请号：US11366186

    申请日：2006-03-01

    申请人： Xiong Gong ,  Alan Heeger ,  Daniel Moses ,  Guillermo Bazan ,  Shu Wang

    发明人： Xiong Gong ,  Alan Heeger ,  Daniel Moses ,  Guillermo Bazan ,  Shu Wang

    IPC分类号： H01L51/54 ,  H01L51/56

    CPC分类号： H01L51/50 ,  H01L51/0003 ,  H01L51/0037 ,  H01L51/0039 ,  H01L51/0042 ,  H01L51/0043 ,  H01L51/007 ,  H01L51/0085 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5036 ,  H01L51/5048 ,  H01L51/5088 ,  Y10S428/917 ,  Y10T428/24942

    摘要： Multilayer polymer light-emitting diodes (PLEDs) are demonstrated using semiconducting polymers blended with organometallic emitters as the emissive layer and one or both of an electron transport layer and a hole transparent layer on the appropriate electron injection and hole injection sides of the emissive layer. The transport layers reduce energy potential gaps between the hole injection electrode and the emissive polymer and between the electron injection electrode and the emissive polymer. A solvent-processing based procedure for preparing these devices is also disclosed It uses nonpolar solvent-based solutions of emissive polymers to form the emissive layer and polar solvent-based solutions to form the transport layers to minimize etching and other undesirable interactions as the multiple layers are being laid down. Illumination quality white light can be obtained with stable Commission Internationale de l'Eclairage coordinates, stable color temperatures, and stable color rendering indices, all close to those of “pure” white light. These multilayer white light-emitting PLEDs are useful as backlights for liquid crystal displays and for solid state lighting applications.

    摘要翻译： 使用与有机金属发射体混合的半导体聚合物作为发射层和在发射层的合适的电子注入和空穴注入侧的电子传输层和空穴透明层中的一个或两个的多层聚合物发光二极管（PLED）。 传输层减少空穴注入电极和发射聚合物之间以及电子注入电极和发射聚合物之间的能量势隙。 还公开了用于制备这些装置的基于溶剂处理的方法。它使用发射聚合物的非极性溶剂型溶液形成发射层和极性溶剂型溶液以形成传输层，以使蚀刻和其它不希望的相互作用最小化，因为多层 正在放下 照明质量白光可以通过稳定的国际照明坐标，稳定的色温和稳定的显色指数获得，均接近于“纯”白光。 这些多层白色发光PLED可用作液晶显示器和固态照明应用的背光。

    Soluble conjugated polymers
    10.
    发明申请
    Soluble conjugated polymers 有权
    可溶性共轭聚合物

    公开(公告)号：US20060247384A9

    公开(公告)日：2006-11-02

    申请号：US11221123

    申请日：2005-09-06

    申请人： Guillermo Bazan ,  Bin Liu

    发明人： Guillermo Bazan ,  Bin Liu

    IPC分类号： C08F297/02

    CPC分类号： C08G61/123 ,  C08F8/44 ,  C08F257/00 ,  C08F279/02 ,  C08F287/00 ,  C08F289/00 ,  C08F291/00 ,  C08G61/02 ,  C08G61/124 ,  C08G61/125 ,  C08G61/126 ,  C08G73/00 ,  C08G73/06 ,  C08G73/08 ,  C08L51/006 ,  C08L51/04 ,  H01L51/0034 ,  H01L51/0035 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/0038 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/5048 ,  C08L2666/02

    摘要： Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.

    摘要翻译： 提供涉及可溶性共轭聚合物的方法，组合物和制品。 共轭聚合物具有足够的极性取代基密度，使其可溶于极性介质，例如水和/或甲醇。 共轭聚合物可以理想地包括改变其导电性能的单体。 在一些实施方案中，本发明人提供了包含增溶基团和导电基团的阳离子共轭聚合物（CCPs），导致可溶于极性介质的导电共轭聚合物。 这些聚合物的不同溶解度特性允许它们以多层形式沉积在其它共轭聚合物中。 还提供了包含具有不同溶解度特性的多层共轭聚合物的制品。 本文进一步描述本发明的实施例。