摘要:
Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): [wherein Ar1 represents 2-methoxy-4-(2-pyridylmethoxy)phenyl etc. and Ar2 represents a 1H-indol-6-yl group etc.] or a salt thereof.
摘要:
Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): [wherein Ar1 represents 2-methoxy-4-(2-pyridylmethoxy)phenyl etc. and Ar2 represents a 1H-indol-6-yl group etc.] or a salt thereof.
摘要:
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要:
A first Peltier device Pe1 and at least one second Peltier device Pe2 having a current consumption smaller than that of the first Peltier device Pe1 are connected to each other in series, while a bypass circuit B for diverting an excess current I3 with respect to the second Peltier device Pe2 is connected to the second Peltier device Pe2 in parallel, so that a driving current I1 from a current control section A drives the first Peltier device Pe1 at its optimum operating point, and the excess current I3 with respect to the second Peltier device Pe2 in the driving current I1 is diverted into the bypass circuit B, so as to allow the second Peltier device Pe2 to be driven at its optimum operating point as well, where by the cooling efficiency can be improved. Also, the first and second Peltier devices Pe1, Pe2 are stacked on each other, while all the Peltier devices Pe1, Pe2 are driven by the single common current control section A, so as to attain a smaller size.
摘要:
A road map display system comprises a map memory for storing map image data, a sensor for detecting the travelling distance and travelling direction and outputting a signal representative of the angular offset between the direction of travel and an axis of a map coordinate system, an arithmetic means for calculating the map coordinates of a point halfway between the vehicle position and the destination, a coordinate transforming means which transforms the map image data to a display coordinate system, the origin of which lies halfway between the vehicle and the destination and the y-axis of which lies parallel to the direction of travel, a display memory in which the map data and symbols representing the destination and the position and the direction of travel of the vehicle are stored in terms of the display coordinate system, and a display means displaying the information stored in the display memory on the display screen.
摘要:
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要:
An electronic apparatus of the invention uses memory information in each of the first memory area to store the end time of the power supply which was executed from the apparatus main body side to a memory card and the second memory area to store information regarding a residue time of a backup power supply element in the memory card which are provided in a memory element in the memory card and the present time information, thereby actually updating the residue information of the backup power supply element in the memory card. The residue information of the backup power supply element every memory card can be individually accurately managed.
摘要:
A navigation instrument comprises a first counter for counting travelling distance from a start point, a second counter for counting travelling time from starting, a means for setting a scheduled average vehicle speed, an arithmetic means for calculating average vehicle speed, the deviation of travelling distance from the scheduled distance and the deviation of travelling time from the scheduled time, and a display means for displaying the result of calculation. The first counter is capable of subtractively counting travelling distance in response to switching operation of a switching means which is incorporated to the first counter. The first counter is also incorporated with a means for stopping navigating operation which is operative when the first counter counts down the travelling distance until a given value.
摘要:
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
摘要:
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.