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公开(公告)号：US5512569A
公开(公告)日：1996-04-30
申请号：US408069
申请日：1995-03-21
申请人： Hamid A. Mansour , Thierry Taverne , Raymond Houssin , Isabelle Lesieur , Patrick Depreux , Geard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
发明人： Hamid A. Mansour , Thierry Taverne , Raymond Houssin , Isabelle Lesieur , Patrick Depreux , Geard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
IPC分类号： A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07D277/68 , C07D417/02
CPC分类号： C07D277/68
摘要： The invention relates to the compounds of formula (I): ##STR1## in which R.sub.1 and R.sup.2 are as defined in the description, the optical isomers thereof,and an addition salt thereof with a pharmaceutically-acceptable acid or base, and medicinal product useful for treating a mammal afflicted with a disease associated with sigma receptors.
摘要翻译： 本发明涉及式（I）化合物：其中R 1和R 2如说明书中所定义，其光学异构体及其与药学上可接受的酸或碱的加成盐，和 用于治疗患有与σ受体相关的疾病的哺乳动物的药用产品。
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公开(公告)号：US5688820A
公开(公告)日：1997-11-18
申请号：US569576
申请日：1995-12-08
申请人： Ange Mouithys-Mickalad , Patrick Depreux , Daniel Lesieur , Gerard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
发明人： Ange Mouithys-Mickalad , Patrick Depreux , Daniel Lesieur , Gerard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/55 , A61P1/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P43/00 , C07D263/58 , C07D277/68 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D413/10 , A61K31/40 , C07D417/10
CPC分类号： C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06 , C07D417/12
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the description, the optical isomers thereof, and the addition salts thereof with a pharmaceutically acceptable acid or base and medicinal product containing the same, useful for treating a mammal afflicted with a pathology associated with the sigma receptors.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，X和n如说明书中所定义，其光学异构体及其加成盐与 药学上可接受的酸或碱和含有该药物的药用产品，其可用于治疗患有与σ受体相关的病理学的哺乳动物。
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公开(公告)号：US5919784A
公开(公告)日：1999-07-06
申请号：US966040
申请日：1997-11-07
申请人： Daniel Lesieur , Pascal Carato , Jean-Paul Bonte , Patrick Depreux , Daniel-Henri Caignard , Mark Millan , Adrian Newman-Tancredi , Pierre Renard , Marie-Claire Rettori
发明人： Daniel Lesieur , Pascal Carato , Jean-Paul Bonte , Patrick Depreux , Daniel-Henri Caignard , Mark Millan , Adrian Newman-Tancredi , Pierre Renard , Marie-Claire Rettori
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61P25/00 , A61P25/18 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , A61K413/10 , A61K417/10 , C07D31/495 , C07D31/535
CPC分类号： C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16
摘要： A compound of general formula (I): ##STR1## where A, X, R.sub.1, Y, n and Ar are defined in the description. Medicinal products containing the same are useful as D.sub.4 receptor Ligands.
摘要翻译： 通式（I）的化合物：其中A，X，R 1，Y，n和Ar在说明书中定义。 含有它们的药物可用作D4受体配体。
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公开(公告)号：US5534511A
公开(公告)日：1996-07-09
申请号：US407238
申请日：1995-03-21
申请人： Ange Mouithys-Mickalad , Patrick Depreux , Daniel Lesieur , Gerard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
发明人： Ange Mouithys-Mickalad , Patrick Depreux , Daniel Lesieur , Gerard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/55 , A61P1/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P43/00 , C07D263/58 , C07D277/68 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D403/00
CPC分类号： C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06 , C07D417/12
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the description, the optical isomers thereof, and the addition salts thereof with a pharmaceutically acceptable acid or base and medicinal product containing the same, useful for treating a mammal afflicted with a pathology associated with the sigma receptors.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，X和n如说明书中所定义，其光学异构体及其加成盐与 药学上可接受的酸或碱和含有该药物的药用产品，其可用于治疗患有与σ受体相关的病理学的哺乳动物。
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公开(公告)号：US5688811A
公开(公告)日：1997-11-18
申请号：US569568
申请日：1995-12-08
申请人： Ange Mouithys-Mickalad , Patrick Depreux , Daniel Lesieur , Gerard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
发明人： Ange Mouithys-Mickalad , Patrick Depreux , Daniel Lesieur , Gerard Adam , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/55 , A61P1/00 , A61P25/18 , A61P25/28 , A61P29/00 , A61P43/00 , C07D263/58 , C07D277/68 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D413/10 , C07D417/10
CPC分类号： C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06 , C07D417/12
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, X and n are as defined in the description, the optical isomers thereof, and the addition salts thereof with a pharmaceutically acceptable acid or base and medicinal product containing the same, useful for treating a mammal afflicted with a pathology associated with the sigma receptors.
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公开(公告)号：US5925665A
公开(公告)日：1999-07-20
申请号：US984673
申请日：1997-12-03
申请人： Marc Payard , Saadia Danoun , Genevieve Baziard-Mouysset , Maria Anastassiadou , Daniel-Henri Caignard , Pierre Renard , Dominique Manechez , Elizabeth Scalbert , Marie-Claire Rettori
发明人： Marc Payard , Saadia Danoun , Genevieve Baziard-Mouysset , Maria Anastassiadou , Daniel-Henri Caignard , Pierre Renard , Dominique Manechez , Elizabeth Scalbert , Marie-Claire Rettori
IPC分类号： A61K31/415 , A61K31/425 , A61P3/04 , A61P3/08 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/24 , A61P25/26 , A61P35/00 , A61P43/00 , C07D233/06 , C07D233/18 , C07D233/20 , C07D233/22 , C07D233/24 , C07D233/26 , C07D233/64 , C07D233/90 , C07D401/04 , C07D403/04 , C07D417/10
CPC分类号： C07D401/04 , C07D233/06 , C07D233/18 , C07D233/20 , C07D233/22 , C07D233/24 , C07D233/90 , C07D403/04 , C07D417/10
摘要： Compound of formula (I): in which R is as defined in the description, as well as their isomers and their pharmaceutically acceptable acid additions salts. Medicinal products containing the same are useful as Imidazoline receptors ligand.
摘要翻译： 式（I）化合物：其中R如说明书中所定义，以及它们的异构体及其药学上可接受的酸加成盐。 含有该药物的药物可用作咪唑啉受体配体。
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公开(公告)号：US5569669A
公开(公告)日：1996-10-29
申请号：US401768
申请日：1995-03-10
申请人： G erald Guillaumet , Marie-Claude Viaud , Pierre Renard , G erard Adam , Daniel-Henri Caignard , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
发明人： G erald Guillaumet , Marie-Claude Viaud , Pierre Renard , G erard Adam , Daniel-Henri Caignard , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
IPC分类号： A61K31/335 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/382 , A61K31/39 , A61K31/47 , A61K31/472 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C217/14 , C07C217/60 , C07C217/62 , C07D215/24 , C07D215/26 , C07D217/02 , C07D237/28 , C07D239/74 , C07D241/42 , C07D307/79 , C07D311/04 , C07D311/58 , C07D317/64 , C07D317/66 , C07D319/08 , C07D319/18 , C07D327/06 , C07D335/06 , C07D339/08
CPC分类号： C07D307/79 , C07C217/60 , C07C217/62 , C07D215/26 , C07D217/02 , C07D237/28 , C07D239/74 , C07D241/42 , C07D311/58 , C07D317/66 , C07D319/08 , C07D319/18 , C07D327/06 , C07D335/06 , C07D339/08 , C07C2102/08
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.2', R.sub.2", R.sub.2'", R.sub.3 and n are as defined in the description, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable acid or base,and medicinal product containing the same useful for treating a mammal afflicted with a disorder associated to 5-HT.sub.1A or 5-HT.sub.2C receptors.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R1，R2，R2'，R2“，R2”'，R3和n如说明书中所定义， 光学异构体及其与药学上可接受的酸或碱的加成盐，以及含有可用于治疗患有与5-HT1A或5-HT2C受体相关的病症的哺乳动物的药物。
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公开(公告)号：US5691340A
公开(公告)日：1997-11-25
申请号：US528251
申请日：1995-09-14
申请人： Genevieve Baziard-Mouysset , Sallouma Younes , Youssef Labssita , Marc Payard , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
发明人： Genevieve Baziard-Mouysset , Sallouma Younes , Youssef Labssita , Marc Payard , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
IPC分类号： C07D295/08 , A61K31/495 , A61P19/02 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P29/00 , A61P43/00 , C07D295/092 , C07D295/18 , C07D295/185 , C07D307/81 , C07D311/16 , C07D311/20 , C07D311/58 , C07D311/66 , C07D405/06
CPC分类号： C07D295/185 , C07D295/088 , C07D307/81 , C07D311/16 , C07D311/58 , C07D311/66
摘要： A compound selected from those of formula (I): ##STR1## where RA, RB, RC, RD, A, n, X, Y and Ar are defined in the description, and a medicinal product comprising the same for treating a mammal afflicted with a disease associated with sigma receptors.
摘要翻译： 选自式（I）的化合物：其中RA，RB，RC，RD，A，n，X，Y和Ar在说明书中定义，其中包含其的治疗药物 患有与σ受体相关的疾病的哺乳动物。
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公开(公告)号：US5668138A
公开(公告)日：1997-09-16
申请号：US677795
申请日：1996-07-10
申请人： Genevieve Baziard-Mouysset , Sallouma Younes , Youssef Labssita , Marc Payard , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
发明人： Genevieve Baziard-Mouysset , Sallouma Younes , Youssef Labssita , Marc Payard , Daniel-Henri Caignard , Pierre Renard , Marie-Claire Rettori
IPC分类号： C07D295/08 , A61K31/495 , A61P19/02 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P29/00 , A61P43/00 , C07D295/092 , C07D295/18 , C07D295/185 , C07D307/81 , C07D311/16 , C07D311/20 , C07D311/58 , C07D311/66 , C07D409/06
CPC分类号： C07D295/185 , C07D295/088 , C07D307/81 , C07D311/16 , C07D311/58 , C07D311/66
摘要： A compound selected from those of formula (I): ##STR1## where RA, RB, RC, RD, A, n, X, Y and Ar are defined in the description, and a medicinal product comprising the same for treating a mammal afflicted with a disease associated with sigma receptors.
摘要翻译： 选自式（I）的化合物：其中RA，RB，RC，RD，A，n，X，Y和Ar在说明书中定义，其中包含其的治疗药物 患有与σ受体相关的疾病的哺乳动物。
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10.发明授权(Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression 失效（芳基（烷基）羰基） - 杂环化合物及其在治疗焦虑和抑郁中的应用
公开(公告)号：US5534517A
公开(公告)日：1996-07-09
申请号：US296665
申请日：1994-08-26
申请人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
发明人： Ousmane Diouf , Daniel Lesieur , Patrick Depreux , Beatrice Guardiola-Lemaitre , Daniel-Henri Caignard , Pierre Renard , Gerard Adam
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06 , A61K31/495 , A61K31/535
CPC分类号： C07D263/58 , C07D277/68 , C07D413/06 , C07D417/06
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## wherein Ar, n, B and A are as defined in the description, to their optical isomers, and to their addition salts there of with a pharmaceutically-acceptable acid or base. The compounds are useful for treating or preventing anxiety and depression.
摘要翻译： 本发明涉及从式（I）的化合物中选择的化合物：其中Ar，n，B和A如说明书中所定义，与它们的光学异构体及其与 药学上可接受的酸或碱。 该化合物可用于治疗或预防焦虑和抑郁。
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