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1.发明授权公开(公告)号：US06585975B1
公开(公告)日：2003-07-01
申请号：US09431705
申请日：1999-11-01
申请人： Harold Kleanthous , Patricia Londono-Arcila , Donna Freeman , Cynthia K. Lee , Thomas P. Monath
发明人： Harold Kleanthous , Patricia Londono-Arcila , Donna Freeman , Cynthia K. Lee , Thomas P. Monath
IPC分类号： A61K3902
CPC分类号： A61K39/105 , A61K2039/523 , A61K2039/541 , C12N15/74 , Y02A50/484
摘要： The invention provides a method of immunization against Helicobacter, involving mucosal administration of an attenuated Salmonella vector including a nucleic acid molecule encoding a Helicobacter antigen, and parenteral administration of a soluble Helicobacter antigen, co-administered with a suitable parenteral adjuvant. Also provided by the invention are attenuated Salmonella vectors for use in this method.
摘要翻译： 本发明提供了针对幽门螺杆菌免疫的方法，涉及粘膜施用减毒沙门氏菌载体，包括编码幽门螺杆菌抗原的核酸分子，以及肠胃外施用可溶性幽门螺杆菌抗原，与合适的肠胃外辅助剂共同施用。 本发明还提供了用于该方法的减毒沙门氏菌载体。
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公开(公告)号：US5837240A
公开(公告)日：1998-11-17
申请号：US920095
申请日：1997-08-26
申请人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
发明人： Cynthia K. Lee , Thomas P. Monath , Samuel K. Ackerman , William D. Thomas , Gopalan Soman , Harold Kleanthous , Richard A. Weltzin , Jacques Pappo , Thomas Ermak , Farshad Guirakhoo , Hitesh Bhagat , Ilene Sussman
IPC分类号： A61K38/46 , A61K39/02 , A61K39/106
CPC分类号： A61K39/105 , Y10S514/925 , Y10S514/926 , Y10S514/927
摘要： Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.
摘要翻译： 提供了用于幽门螺杆菌的预防和抗菌治疗的方法和组合物，特别是用于幽门螺杆菌，人的感染。 本发明的免疫原性组合物由多个多聚体复合物组成，每个复合物由重组的酶促活化的幽门螺旋杆菌脲酶组成。 每个多聚体复合物由六个脲酶A亚基和六个脲酶B亚基组成。 或者，组合物由多聚体复合物的混合物组成，其中混合物中的每个多聚复合物由六个脲酶A亚基和六个脲酶B亚基或四个脲酶A亚基和四个脲酶B亚基组成。
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3.发明授权公开(公告)号：US08741312B2
公开(公告)日：2014-06-03
申请号：US13012917
申请日：2011-01-25
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , Y02A50/388
摘要： The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.
摘要翻译： 本发明提供了一种非活性的非复制疫苗，其包含完整的病毒体，化学灭活的黄热病病毒，其使用确保保存关键的中和表位的方法灭活。 黄热病病毒已经适应于在细胞中传播比未适应病毒更高的产量。 本发明还提供了防止黄热病毒感染的方法。
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公开(公告)号：US20130177592A1
公开(公告)日：2013-07-11
申请号：US13457821
申请日：2012-04-27
IPC分类号： A61K39/08
CPC分类号： A61K39/08 , A61K39/00 , A61K39/39 , A61K2039/505 , A61K2039/521 , A61K2039/54 , A61K2039/55505 , A61K2039/55511 , C07K14/33 , C07K16/1282 , C07K2317/76 , C12N9/1051 , G01N33/56911 , G01N2333/33 , G01N2469/20
摘要： The invention provides active and passive immunization methods for preventing and treating Clostridium difficile infection, which involve percutaneous administration of C. difficile toxin-neutralizing polyclonal immune globulin, C. difficile toxoids, or combinations thereof. Also provided by the invention are C. difficile toxoids, C. difficile toxin-neutralizing polyclonal immune globulin, and methods of identifying subjects that produce C. difficile toxin-neutralizing polyclonal immune globulin.
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公开(公告)号：US20120288520A1
公开(公告)日：2012-11-15
申请号：US13406153
申请日：2012-02-27
CPC分类号： C12N7/00 , C07K14/005 , C12N2710/16234 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
摘要翻译： 本发明提供可用于预防和治疗黄病毒感染的重组黄病毒疫苗。 本发明的疫苗含有重组黄病毒，包括减毒突变。
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公开(公告)号：US07459160B2
公开(公告)日：2008-12-02
申请号：US10345036
申请日：2003-01-15
CPC分类号： A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394
摘要： The invention provides flavivirus vaccines and methods of making and using these vaccines.
摘要翻译： 本发明提供黄病毒疫苗和制备和使用这些疫苗的方法。
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公开(公告)号：US20080193477A1
公开(公告)日：2008-08-14
申请号：US12063365
申请日：2006-08-09
申请人： Thomas P. Monath , Farshad Guirakhoo , Niranjan Kanesa-thasan , Thomas H. Ermak , Jean Lang , Remi Forrat
发明人： Thomas P. Monath , Farshad Guirakhoo , Niranjan Kanesa-thasan , Thomas H. Ermak , Jean Lang , Remi Forrat
IPC分类号： A61K39/295 , A61K39/12 , A61P31/14
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/70 , C12N2770/24134 , Y02A50/386 , Y02A50/388
摘要： This invention relates to methods and kits for use in vaccination against dengue virus infection.
摘要翻译： 本发明涉及用于针对登革热病毒感染的疫苗接种中的方法和试剂盒。
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公开(公告)号：US20080175862A1
公开(公告)日：2008-07-24
申请号：US11912482
申请日：2006-04-24
CPC分类号： C12N7/00 , C07K14/005 , C12N2710/16234 , C12N2770/24122 , C12N2770/24134 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The invention provides recombinant flavivirus vaccines that can be used in the prevention and treatment of flavivirus infection. The vaccines of the invention contain recombinant flaviviruses including attenuating mutations.
摘要翻译： 本发明提供可用于预防和治疗黄病毒感染的重组黄病毒疫苗。 本发明的疫苗含有重组黄病毒，包括减毒突变。
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公开(公告)号：US20120201852A1
公开(公告)日：2012-08-09
申请号：US13251424
申请日：2011-10-03
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The invention provides attenuated Flavivirus vaccines, such as vaccines against Japanese encephalitis virus and West Nile virus, as well as methods of making and using these vaccines.
摘要翻译： 本发明提供减毒黄病毒疫苗，例如针对日本脑炎病毒和西尼罗河病毒的疫苗，以及制备和使用这些疫苗的方法。
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公开(公告)号：US20100278773A1
公开(公告)日：2010-11-04
申请号：US12592529
申请日：2009-11-25
IPC分类号： A61K39/12 , A61K39/29 , A61K39/00 , A61K38/21 , A61K38/20 , A61P35/00 , A61P31/14 , C12N7/01 , C07H21/04
CPC分类号： A61K39/29 , A61K35/13 , A61K39/00 , A61K39/12 , A61K39/193 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24143 , C12N2770/24161 , C12N2770/24162 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional prM-E protein is not expressed, and integrated into the genome of the yellow fever virus, a nucleotide sequence encoding a prM-E protein of a second, different flavivirus, so that the prM-E protein of the second flavivirus is expressed.
摘要翻译： 含有黄热病毒的嵌合的活的，感染性的，减毒的病毒，其中prM-E蛋白的核苷酸序列被缺失，截短或突变，使得功能性prM-E蛋白不被表达并整合到基因组中 的黄热病病毒，编码第二种不同黄病毒的prM-E蛋白的核苷酸序列，从而表达第二种黄病毒的prM-E蛋白。
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