公开(公告)号：US20080108910A1

公开(公告)日：2008-05-08

申请号：US11868505

申请日：2007-10-07

申请人： Heinz-Michael Hein ,  Reto Abt ,  Stephan Korner ,  Irio Calasso ,  Emad Sarofim ,  Patrick Griss ,  Rainer Jaeggi

发明人： Heinz-Michael Hein ,  Reto Abt ,  Stephan Korner ,  Irio Calasso ,  Emad Sarofim ,  Patrick Griss ,  Rainer Jaeggi

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61M5/00

CPC分类号： A61B5/150503 ,  A61B5/0531 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15186

摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.

摘要翻译： 本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。 穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。 随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。 在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。 在等待期开始和结束后的前进阶段之后检测穿刺元件与体液之间的接触。

公开(公告)号：US20070118051A1

公开(公告)日：2007-05-24

申请号：US11539675

申请日：2006-10-09

申请人： Stephan Korner ,  Rainer Jaeggi ,  Patrick Griss ,  Emad Sarofim ,  Irio Calasso

发明人： Stephan Korner ,  Rainer Jaeggi ,  Patrick Griss ,  Emad Sarofim ,  Irio Calasso

IPC分类号： A61B5/00

CPC分类号： A61B5/150068 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150816 ,  A61B5/150954 ,  A61B5/15113 ,  A61B5/157

摘要： A system and method for carrying out the withdrawal of body fluid with as little body fluid as possible visible to the user at the end of the process. The present invention provides a pressure piece for exerting pressure on a body part. The pressure piece is moved relative to a support for the body part, and in the final phase of fluid withdrawal, the compressive or resistive force of the pressure piece on the body part is reduced in order to avoid the escape of body fluid from the puncture site. The support results in a defined positioning of the body part that rests against it for the lancing process, whereas the relative movement of the pressure piece enables an additional increase in pressure and thus an improved collection of fluid.

摘要翻译： 一种系统和方法，用于在过程结束时用尽可能少的体液抽出体液，以使用户可以看到。 本发明提供一种用于在身体部位施加压力的压力片。 压片相对于身体部分的支撑件移动，并且在流体抽出的最后阶段中，压力片在身体部分上的压缩或阻力减小，以避免体液从穿刺中逸出 现场。 支撑件导致身体部分的定位，其靠在其上以用于穿刺过程，而压力片的相对运动使得能够额外增加压力，从而改善流体的收集。

公开(公告)号：US20110257493A1

公开(公告)日：2011-10-20

申请号：US13167243

申请日：2011-06-23

申请人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer

发明人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer

IPC分类号： A61B5/157 ,  A61B5/15

CPC分类号： A61B5/14532 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150251 ,  A61B5/150297 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117

摘要： Body fluid sampling device comprising a sampling element having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving means (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving means initially. The fluid receiving means has two or more test zones (45) for performing analytical reactions. Fluid from the channel is contacted with the fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.

摘要翻译： 体液取样装置包括具有用于接收体液的流体通道（11）的采样元件，流体通路的至少一部分对环境开放，并且还包括与流体通道间隔开的流体接收装置（40） 路径中的流体最初不会接触流体接收装置。 流体接收装置具有用于进行分析反应的两个或更多个测试区（45）。 来自通道的流体通过使流体接收装置和流体机械接触或者将流体从流路电输送到流体接收装置上而与流体接收装置接触。

公开(公告)号：US20070038149A1

公开(公告)日：2007-02-15

申请号：US11470021

申请日：2006-09-05

申请人： Irio Calasso ,  Patrick Griss ,  Rainer Jaeggi ,  Emad Sarofim

发明人： Irio Calasso ,  Patrick Griss ,  Rainer Jaeggi ,  Emad Sarofim

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150251 ,  A61B5/150297 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117

摘要： Body fluid sampling device comprising a skin-piercing element (10) having a fluid pathway (11) for receiving body fluid, at least a portion of said fluid pathway is open to the environment and further comprising a fluid receiving means (40) being spaced from said fluid pathway so that fluid in said pathway will not contact the fluid receiving means initially. Said fluid receiving means may have a test zone (45) for performing an analytical reaction. Fluid from said channel is contacted with said fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.

摘要翻译： 体液取样装置包括具有用于接收体液的流体通道（11）的皮肤刺穿元件（10），所述流体通道的至少一部分对环境开放，并且还包括间隔开的流体接收装置（40） 从所述流体通道使得所述通路中的流体最初不会接触流体接收装置。 所述流体接收装置可以具有用于进行分析反应的测试区（45）。 来自所述通道的流体与所述流体接收装置接触，通过使流体接收装置和流体进入机械接触或者将流体从通道电输送到流体接收装置上。

公开(公告)号：US20070016103A1

公开(公告)日：2007-01-18

申请号：US11470368

申请日：2006-09-06

申请人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilfried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven Roe

发明人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilfried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven Roe

IPC分类号： A61B5/00

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150396 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/15045 ,  A61B5/150503 ,  A61B5/15151 ,  A61B5/15163

摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid, and the device further comprising a fluid receiving means remote spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially. The collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0.5 seconds. The fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from the collection zone is automatically or manually transported to the fluid receiving means to contact the fluid with the test zone.

摘要翻译： 体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件，并且该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液不会接触流体接收装置 原来。 收集区在小于0.5秒的非常短的时间段内占据非常小体积的体液约10至500nl。 流体接收装置可以具有用于进行分析反应的测试区域。 来自收集区的流体样品被自动或手动地输送到流体接收装置以使流体与测试区接触。

公开(公告)号：US20060293611A1

公开(公告)日：2006-12-28

申请号：US11469123

申请日：2006-08-31

申请人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer

发明人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1411 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150251 ,  A61B5/150297 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117

摘要： Body fluid sampling device comprising a sampling element having a fluid pathway (11) for receiving body fluid, at least a portion of the fluid pathway is open to the environment and further comprising a fluid receiving means (40) being spaced from the fluid pathway so that fluid in the pathway will not contact the fluid receiving means initially. The fluid receiving means has two or more test zones (45) for performing analytical reactions. Fluid from the channel is contacted with the fluid receiving means either by bringing the fluid receiving means and the fluid into mechanical contact or by electrically transporting fluid from the channel onto the fluid receiving means.

摘要翻译： 体液取样装置包括具有用于接收体液的流体通道（11）的采样元件，流体通路的至少一部分对环境开放，并且还包括与流体通道间隔开的流体接收装置（40） 路径中的流体最初不会接触流体接收装置。 流体接收装置具有用于进行分析反应的两个或更多个测试区（45）。 来自通道的流体通过使流体接收装置和流体机械接触或通过将流体从流路电输送到流体接收装置上而与流体接收装置接触。

公开(公告)号：US20110009774A1

公开(公告)日：2011-01-13

申请号：US12879500

申请日：2010-09-10

申请人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilifried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven N. Roe

发明人： Irio Calasso ,  Patrick Griss ,  Emad Sarofim ,  Rainer Jaeggi ,  Uwe Kraemer ,  Dave Hasker ,  Volker Zimmer ,  Wilifried Schmid ,  Otto Fuerst ,  Hans List ,  Hans-Peter Haar ,  Theo Arnitz ,  Steven N. Roe

IPC分类号： A61B5/151

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150396 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/15045 ,  A61B5/150503 ,  A61B5/15151 ,  A61B5/15163

摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.

摘要翻译： 体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。 在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。 孔尺寸可以较小，例如具有0.01至0.5mm的直径。 这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。 在一些实施例中，孔的深度为50至500μm。 在其它实施方案中，收集区是多孔的，或者是粗糙区域。 收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。 在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

公开(公告)号：US20070197937A1

公开(公告)日：2007-08-23

申请号：US11676398

申请日：2007-02-19

申请人： Emad Sarofim ,  Irio Calasso ,  Patrick Griss

发明人： Emad Sarofim ,  Irio Calasso ,  Patrick Griss

IPC分类号： A61B5/00

CPC分类号： B01L3/502707 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/15045 ,  A61B5/15105 ,  A61B5/15142 ,  A61B2562/0295 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/0825 ,  B01L2400/0406

摘要： The invention generally concerns a microfluidic system having a support body provided with a lancing member and a semi-open microchannel, for the capillary transport of a sample fluid from a receiving site to a target site. In order to obtain a higher aspect ratio the support body is coated with a build-up layer which laterally defines the microchannel in the upper region.

摘要翻译： 本发明一般涉及具有支撑体的微流体系统，所述支撑体设有穿刺构件和半开放微通道，用于将样品流体从接收部位毛细管输送到目标部位。 为了获得更高的纵横比，支撑体涂覆有在上部区域中侧向限定微通道的积聚层。

公开(公告)号：US20070299365A1

公开(公告)日：2007-12-27

申请号：US11746386

申请日：2007-05-09

申请人： Irio Calasso ,  Emad Sarofim

发明人： Irio Calasso ,  Emad Sarofim

IPC分类号： A61B5/00

CPC分类号： A61B5/150503 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/15105 ,  A61B5/15142

摘要： The invention generally relates to a sampling system for sample liquid having a support, a lancing element arranged thereon and a semi-open channel for the capillary transport of the sample liquid from the lancing element to a collecting site on the support. A receiving structure is provided for receiving excess sample liquid escaping from the side of the channel.

摘要翻译： 本发明一般涉及一种用于样品液体的采样系统，其具有支撑件，布置在其上的穿刺元件和用于将样品液体从穿刺元件毛细管输送到支撑体上的收集位置的半开口通道。 提供接收结构，用于接收从通道侧排出的多余的样品液体。

公开(公告)号：US20080056947A1

公开(公告)日：2008-03-06

申请号：US11828959

申请日：2007-07-26

申请人： Michael Glauser ,  Hans-Peter Wahl ,  Irio Calasso ,  Emad Sarofim

发明人： Michael Glauser ,  Hans-Peter Wahl ,  Irio Calasso ,  Emad Sarofim

IPC分类号： B01J19/00 ,  B05D1/02 ,  B05D3/00 ,  B05D3/04 ,  B05D7/22

CPC分类号： A61B5/1411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15142 ,  A61B2562/0295 ,  B01L3/502707 ,  B01L2300/0825 ,  B01L2300/161 ,  B01L2300/163 ,  B01L2400/0406 ,  Y10T436/2575

摘要： A microfluidic system having a microchannel for the capillary transport of a liquid, in particular a body fluid for analytical purposes. The microchannel is provided with a surface coating comprising at least one hydrophilic substance selected from the group consisting of polyacrylic acid, polyacrylate, dextran sulfate and chondroitin sulfate. The invention also concerns a coating method that is suitable for this.

摘要翻译： 一种微流体系统，具有用于毛细管理液体的微通道，特别是用于分析目的的体液。 微通道设置有包含至少一种选自聚丙烯酸，聚丙烯酸酯，硫酸葡聚糖和硫酸软骨素的亲水性物质的表面涂层。 本发明还涉及适合于此的涂布方法。