-
1.APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20110237553A1
公开(公告)日:2011-09-29
申请号:US13049569
申请日:2011-03-16
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/635 , C07D295/155 , A61P35/00 , A61P35/02 , C07D211/58 , C07C311/51 , A61K31/63
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
-
公开(公告)号:US08188077B2
公开(公告)日:2012-05-29
申请号:US13049569
申请日:2011-03-16
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/5377 , A61K31/5375 , A61K31/435 , A61K31/437 , C07D413/02 , C07D241/02 , C07D295/00 , C07D211/00
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
公开(公告)号:US20120214796A1
公开(公告)日:2012-08-23
申请号:US13458968
申请日:2012-04-27
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/18 , A61K31/495 , A61K31/55 , A61K31/439 , A61K31/5377 , A61K31/496 , A61P35/00 , A61K31/451
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
公开(公告)号:US08343967B2
公开(公告)日:2013-01-01
申请号:US13458968
申请日:2012-04-27
申请人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
发明人: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC分类号: A61K31/5377 , A61K31/5375 , A61K31/435 , A61K31/437 , C07D413/02 , C07D241/02 , C07D295/00 , C07D211/00
CPC分类号: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
5.Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 有权
标题翻译: 凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病公开(公告)号:US08338466B2
公开(公告)日:2012-12-25
申请号:US12689133
申请日:2010-01-18
申请人: Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
发明人: Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
IPC分类号: C07D277/00
CPC分类号: C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
-
公开(公告)号:US20100184766A1
公开(公告)日:2010-07-22
申请号:US12689133
申请日:2010-01-18
申请人: Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
发明人: Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
IPC分类号: A61K31/496 , C07D409/02 , C07D409/14 , C07D417/02 , C07D413/02 , A61K31/4535 , A61K31/5377 , A61P35/00 , A61P35/02
CPC分类号: C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
公开(公告)号:US20100184750A1
公开(公告)日:2010-07-22
申请号:US12689106
申请日:2010-01-18
申请人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号: A61K31/549 , C07D241/04 , A61K31/495 , C07D403/12 , A61K31/496 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D417/12 , C07D405/12 , A61P35/00 , A61P35/02
CPC分类号: C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
公开(公告)号:US08426422B2
公开(公告)日:2013-04-23
申请号:US12689106
申请日:2010-01-18
申请人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号: A61K31/496 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14 , C07D295/155
CPC分类号: C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
-
9.
公开(公告)号:US08586754B2
公开(公告)日:2013-11-19
申请号:US12793418
申请日:2010-06-03
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: C07D209/32 , C07D401/10
CPC分类号: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
-
10.APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20100298323A1
公开(公告)日:2010-11-25
申请号:US12793413
申请日:2010-06-03
申请人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: A61K31/496 , C07D405/12 , C07D405/14 , C07D413/14 , C07D413/12 , C07D295/155 , C07D403/14 , C07D401/12 , C07D417/14 , A61K31/5377 , A61K31/495 , A61P35/00 , A61P35/02
CPC分类号: C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
-
-
-
-
-
-
-
-
-