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1.APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20100298323A1
公开(公告)日:2010-11-25
申请号:US12793413
申请日:2010-06-03
申请人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: A61K31/496 , C07D405/12 , C07D405/14 , C07D413/14 , C07D413/12 , C07D295/155 , C07D403/14 , C07D401/12 , C07D417/14 , A61K31/5377 , A61K31/495 , A61P35/00 , A61P35/02
CPC分类号: C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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公开(公告)号:US08586754B2
公开(公告)日:2013-11-19
申请号:US12793418
申请日:2010-06-03
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: C07D209/32 , C07D401/10
CPC分类号: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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3.
公开(公告)号:US20100298321A1
公开(公告)日:2010-11-25
申请号:US12793418
申请日:2010-06-03
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: A61K31/5377 , A61P35/04 , A61K31/497 , A61K31/4439 , A61K31/415 , A61K31/405 , A61K31/18 , C07D413/02 , C07D413/12 , C07D413/14 , C07D401/12 , C07D235/04 , C07D209/04 , C07C311/00 , A61P35/00
CPC分类号: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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4.APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20100305122A1
公开(公告)日:2010-12-02
申请号:US12787682
申请日:2010-05-26
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC分类号: A61K31/5377 , A61P35/00 , A61P35/04 , C07D471/04 , A61K31/496
CPC分类号: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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5.APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20120190688A1
公开(公告)日:2012-07-26
申请号:US13430610
申请日:2012-03-26
申请人: Milan Bruncko , Hong Ding , George A. Doherly , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherly , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC分类号: A61K31/496 , A61P37/00 , A61P35/02 , C07D471/04 , A61P35/00
CPC分类号: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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公开(公告)号:US20110124628A1
公开(公告)日:2011-05-26
申请号:US12951344
申请日:2010-11-22
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号: A61K31/496 , C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14 , A61K31/5377 , A61K31/517 , A61K31/541 , A61P35/00 , A61P35/02
CPC分类号: C07D471/04 , C07D491/052 , C07D519/00
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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7.Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases 有权
标题翻译: 凋亡诱导剂用于治疗癌症和免疫和自身免疫性疾病公开(公告)号:US08546399B2
公开(公告)日:2013-10-01
申请号:US12787682
申请日:2010-05-26
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号: A61K31/407 , C07D401/12
CPC分类号: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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公开(公告)号:US08557983B2
公开(公告)日:2013-10-15
申请号:US12793413
申请日:2010-06-03
申请人: George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
发明人: George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
IPC分类号: C07D403/14 , C07D413/14
CPC分类号: C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号:US08580794B2
公开(公告)日:2013-11-12
申请号:US12951344
申请日:2010-11-22
申请人: George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Andrew J. Souers , Zhi-Fu Tao , Gary T. Wang , Le Wang , Robert Mantei , Todd M. Hansen
发明人: George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Andrew J. Souers , Zhi-Fu Tao , Gary T. Wang , Le Wang , Robert Mantei , Todd M. Hansen
IPC分类号: A61K31/407 , C07D401/12
CPC分类号: C07D471/04 , C07D491/052 , C07D519/00
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号:US08202878B2
公开(公告)日:2012-06-19
申请号:US11947005
申请日:2007-11-29
申请人: Andrew J. Souers , Ju Gao , Todd M. Hansen , Rajesh R. Iyengar , Philip R. Kym , Bo Liu , Zhonghua Pei , Vince S. Yeh , Gang Zhao , Zhili Xin
发明人: Andrew J. Souers , Ju Gao , Todd M. Hansen , Rajesh R. Iyengar , Philip R. Kym , Bo Liu , Zhonghua Pei , Vince S. Yeh , Gang Zhao , Zhili Xin
IPC分类号: C07D487/04 , A61K31/519 , A61P3/04 , A61P3/10 , C07D231/20 , A61K31/4152
CPC分类号: C07D487/04 , C07C59/54 , C07C275/42 , C07D211/60 , C07D231/12 , C07D231/20 , C07D249/08 , C07D263/48 , C07D277/40 , C07D401/04 , C07D407/12 , C07D407/14 , C07D413/12 , C07D413/14
摘要: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, a pharmaceutical composition of formula (I), and related methods for treating or preventing metabolic diseases or conditions.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,式(I)的药物组合物以及用于治疗或预防代谢性疾病或病症的相关方法。
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