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    Control of Cell Electroporation
    2.
    发明申请
    Control of Cell Electroporation 有权

    公开(公告)号：US20210371796A1

    公开(公告)日：2021-12-02

    申请号：US17326897

    申请日：2021-05-21

    Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

    Inventor： Bastien Duckert ,  Dries Braeken ,  Maarten Fauvart

    IPC: C12M1/42 ,  C12N13/00

    Abstract: An electrode unit for performing electroporation of a biological cell is provided, including at least one electrode which can contact a cell. A stimulation unit and an impedance measurement device are connected to the cell, respectively to provide signals to provide cell electroporation and to measure the impedance of the electrode in contact with the cell. Further, a memory stores a predetermined value of an impedance parameter of the biological cell, and it is arranged to be readable by a comparing element. The comparing element is configured to compare the value stored in the memory with a value measured with the impedance measurement device, and to produce an adjustment signal to the stimulation unit, forming a feedback loop. The unit is further configured to apply a further electrical signal for providing electroporation of the cell upon receiving the adjustment signal from the comparing element.

    Method and Device for Drug Screening
    6.
    发明申请
    Method and Device for Drug Screening 审中-公开

    公开(公告)号：US20170115201A1

    公开(公告)日：2017-04-27

    申请号：US15129267

    申请日：2015-04-03

    Applicant: IMEC VZW

    Inventor： Veerle Reumers ,  Dries Braeken ,  Geert Vanmeerbeeck ,  Richard Stahl ,  Andy Lambrechts

    IPC: G01N15/10 ,  G01N15/14 ,  G03H1/04 ,  G01N33/50 ,  G03H1/00 ,  G01N21/47 ,  G01N21/17

    Abstract: The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.

    Methods and Systems for Labelling Nucleic Acids
    8.
    发明申请
    Methods and Systems for Labelling Nucleic Acids 有权

    公开(公告)号：US20220333196A1

    公开(公告)日：2022-10-20

    申请号：US17720005

    申请日：2022-04-13

    Applicant: IMEC VZW

    Inventor： Dries Braeken

    IPC: C12Q1/6881 ,  C12N13/00

    Abstract: Systems and methods are provided for labelling nucleic acids in a cell of a cell culture or of a tissue. The systems and methods include contacting the cell culture or tissue with a first label and applying an electrical field to the cell, thereby increasing the permeability of the cell membrane, allowing the first label to be introduced into the cell. The cell culture or tissue can be disposed on a multielectrode array, and the electrical field can be applied by operating one or more electrodes of the array that are proximate to (e.g., beneath) the cell in order to control the location of the cell whose permeability is increased and/or to control the timing of such permeability increase.

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