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    System and Method for Label-Free Cell Identification and/or Classification and/or Selection
    1.
    发明申请
    System and Method for Label-Free Cell Identification and/or Classification and/or Selection 有权

    公开(公告)号：US20250114793A1

    公开(公告)日：2025-04-10

    申请号：US18909640

    申请日：2024-10-08

    Applicant: IMEC VZW

    Inventor： Christopher Adams ,  Peter Peumans ,  Andy Lambrechts ,  Murali Jayapala ,  Tim Stakenborg

    IPC: B01L3/00 ,  G01N15/1429

    Abstract: A system for label-free identification and/or classification and/or selection of at least one cell is provided. The system comprises a microfluidic environment configured to be traversable by the at least one cell, an imaging sensor configured to gather imaging information with respect to at least a part of the microfluidic environment, and a processing unit connected to the imaging sensor. In this context, the microfluidic environment comprises at least one sub-environment configured to interact with the at least one cell. Furthermore, the processing unit is configured to detect at least one sub-environment interaction event based on persistence of the at least one cell imaged by the imaging sensor in the temporal domain. In addition to this, the processing unit is configured to identify and/or classify and/or select the at least one cell based on the at least one sub-environment interaction event.

    Use of spectral leaks to obtain high spatial resolution information for hyperspectral imaging
    3.
    发明授权
    Use of spectral leaks to obtain high spatial resolution information for hyperspectral imaging 有权

    公开(公告)号：US11095835B2

    公开(公告)日：2021-08-17

    申请号：US16722877

    申请日：2019-12-20

    Applicant: IMEC VZW

    Inventor： Nicolaas Tack ,  Andy Lambrechts

    IPC: H04N5/33 ,  G02B5/28 ,  H04N5/357 ,  H04N5/374

    Abstract: An example method and hyperspectral imaging (HSI) system for imaging a scene are provided. The method is for imaging the scene with the HSI system including a sensor with a plurality of sensor pixels and a plurality of spectral filters, each of the spectral filters being associated with one of the sensor pixels. The method comprises obtaining a higher-resolution spatial image by illuminating the scene with a first set of wavelengths, wherein each spectral filter passes the first set of wavelengths to the sensor pixel it is associated with. The method further comprises obtaining a lower-resolution hyperspectral image by illuminating the scene with a second set of wavelengths, wherein each spectral filter passes only a subset of the second set of wavelengths to the sensor pixel it is associated with.

    Apparatus and method for performing in-line lens-free digital holography of an object
    4.
    发明授权
    Apparatus and method for performing in-line lens-free digital holography of an object 有权

    公开(公告)号：US10126709B2

    公开(公告)日：2018-11-13

    申请号：US15727832

    申请日：2017-10-09

    Applicant: IMEC VZW

    Inventor： Richard Stahl ,  Murali Jayapala ,  Andy Lambrechts ,  Geert Vanmeerbeeck

    IPC: G03H1/04 ,  G03H1/26 ,  G01N15/14 ,  G01N15/10

    Abstract: Embodiments described herein relate to lens-free imaging. One example embodiment may include a lens-free imaging device for imaging a moving sample. The lens-free imaging device may include a radiation source configured to emit a set of at least two different wavelengths towards the moving sample. The lens-free imaging device is configured to image samples for which a spectral response does not substantially vary for a set of at least two different wavelengths. The lens-free imaging device may also include a line scanner configured to obtain a line scan per wavelength emitted by the radiation source and reflected by, scattered by, or transmitted through the moving sample. The line scanner is configured to regularly obtain a line scan per wavelength. Either the radiation source or the line scanner is configured to isolate data of the at least two different wavelengths.

    SPECTROMETER MODULE
    9.
    发明申请
    SPECTROMETER MODULE 审中-公开

    公开(公告)号：US20170184452A1

    公开(公告)日：2017-06-29

    申请号：US15389043

    申请日：2016-12-22

    Applicant: IMEC VZW

    Inventor： Jerome Baron ,  Jonathan Borremans ,  Andy Lambrechts

    IPC: G01J3/02 ,  G01J3/28 ,  G01J3/12

    CPC classification number: G01J3/0264 ,  G01J3/0262 ,  G01J3/0291 ,  G01J3/12 ,  G01J3/28 ,  G01J3/2803 ,  G01J2003/1213 ,  G01J2003/2806 ,  G01J2003/2826 ,  G01J2003/2866

    Abstract: A spectrometer module comprising a plurality of separate electronic circuit modules is disclosed. Each separate electronic module comprises an integrated sensor circuit including a light sensitive area occupying part of an area of the integrated sensor circuit, the integrated sensor circuit being arranged to detect incident light. In one aspect, the plurality of separate electronic circuit modules includes a group of adjacent electronic circuit modules. The light sensitive areas of the electronic circuit modules in the group are so arranged on the respective integrated sensor circuits that the group of adjacent electronic circuit modules is mounted so that the light sensitive areas thereof are arranged in vicinity to each other. The spectrometer module includes an optical module, which is common to said plurality of separate electronic circuit modules and arranged to direct incident light towards the light sensitive areas of each of said electronic circuit modules.

    Apparatus and Method for Performing In-Line Lens-Free Digital Holography of an Object
    10.
    发明申请
    Apparatus and Method for Performing In-Line Lens-Free Digital Holography of an Object 有权
    用于执行对象的在线无镜头数字全息摄影的装置和方法

    公开(公告)号：US20170031318A1

    公开(公告)日：2017-02-02

    申请号：US15039549

    申请日：2014-12-02

    Applicant: IMEC VZW

    Inventor： Richard Stahl ,  Murali Jayapala ,  Andy Lambrechts ,  Geert Vanmeerbeeck

    IPC: G03H1/04 ,  H04N5/33 ,  H04N9/04

    CPC classification number: G03H1/0443 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/147 ,  G01N2015/1454 ,  G03H1/0404 ,  G03H1/0465 ,  G03H1/0486 ,  G03H1/0493 ,  G03H1/0866 ,  G03H2001/0212 ,  G03H2001/0428 ,  G03H2001/0447 ,  G03H2001/0452 ,  G03H2001/0497 ,  G03H2001/266 ,  G03H2210/12 ,  G03H2210/13 ,  G03H2222/14 ,  G03H2226/11 ,  G03H2240/62 ,  H04N5/332 ,  H04N9/045

    Abstract: The present disclosure relates to apparatuses and methods for performing in-line lens-free digital holography of objects. At least one embodiment relates to an apparatus for performing in-line lens-free digital holography of an object. The apparatus includes a point light source adapted for emitting coherent light. The apparatus also includes an image sensing device adapted and arranged for recording interference patterns resulting from interference from light waves directly originating from the point light source and object light waves. The object light waves originate from light waves from the point light source that are scattered or reflected by the object. The image sensing device comprises a plurality of pixels. The point light source comprises a broad wavelength spectrum light source and a pinhole structure. The image sensing device comprises a respective narrow band wavelength filter positioned above each pixel that filters within a broad wavelength spectrum of the point light source.

    Abstract translation: 本公开涉及用于执行物体的无线透镜数字全息术的装置和方法。 至少一个实施例涉及一种用于执行物体的直线无镜头数字全息术的装置。 该装置包括适于发射相干光的点光源。 该装置还包括适于和布置用于记录由直接源自点光源和物体光波的光波的干扰引起的干涉图案的图像感测装置。 物体光波源自被物体散射或反射的点光源的光波。 图像感测装置包括多个像素。 点光源包括宽波长光谱光源和针孔结构。 图像感测装置包括位于每个像素上方的相应的窄带波长滤波器，其在点光源的宽波长光谱内进行滤波。

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