公开(公告)号：US11913861B2

公开(公告)日：2024-02-27

申请号：US17330121

申请日：2021-05-25

申请人： IonSense Inc.

发明人： Brian D Musselman ,  Frederick Li

IPC分类号： G01N1/38 ,  G01N1/44 ,  H01J49/16 ,  H01J49/12 ,  H01J49/04

CPC分类号： G01N1/38 ,  G01N1/44 ,  H01J49/0459 ,  H01J49/12 ,  H01J49/165 ,  G01N2001/386

摘要： Methods and devices for pretreatment of a conducting sampling substrate which enable an electrostatic charge to be used to transfer analyte molecules onto a sampling substrate, where the analyte molecules are in powder or particulate form. In an embodiment of the present invention, the electrostatic charge can be used to transfer powder samples containing nitrogenous bases, nucleosides, food additives, and prescription drugs such as acetaminophen, oxycodone, and dextromethorphan. In an embodiment of the present invention, a powder sample is transferred to a pre-treated sampling substrate using an electrostatic charge. The spatial distribution of the powder on the original surface is retained on the pre-treated sampling substrate using the electrostatic charge transfer. The electrostatic charge transfer can be used to transfer powder samples present on a surface or in the chambers of 96, 384 and 1536 well plate formats to either pins or mesh and analyzed with ambient desorption ionization.

公开(公告)号：US20220013347A1

公开(公告)日：2022-01-13

申请号：US17266246

申请日：2020-10-26

申请人： IonSense Inc..

发明人： Scott Oro ,  Brian D Musselman

IPC分类号： H01J49/16 ,  H01J49/14 ,  H01J49/42

摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by pulsing the carrier gas used to generate the excited species directed at the sample. The excited species are stepwise directed at the sample reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present ambient ionization experiment, the combination of stepping the sample in front of the excited species and pulsing the carrier gas used to generate the excited species increases the sensitivity of detection.

公开(公告)号：US09337007B2

公开(公告)日：2016-05-10

申请号：US14738899

申请日：2015-06-14

申请人： IONSENSE INC.

发明人： Brian D Musselman

IPC分类号： H01J49/00 ,  H01J49/16

CPC分类号： H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

摘要翻译： 本发明涉及一种生成分析物混合物的化学特征的方法和装置。 本发明涉及使用SPME表面吸收和吸附分析物混合物中的一种或两种。 在本发明的一个实施方案中，然后将表面暴露于用适当的空间分辨率选择的不同温度的离子化物质以解吸分析物混合物的化学特征。

公开(公告)号：US10283340B2

公开(公告)日：2019-05-07

申请号：US16104479

申请日：2018-08-17

申请人： IONSENSE INC.

发明人： Brian D Musselman

IPC分类号： H01J49/00 ,  H01J49/16 ,  G01N1/40 ,  H01J49/04 ,  G01N30/00 ,  G01N30/06 ,  G01N1/02

摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

公开(公告)号：US09390899B2

公开(公告)日：2016-07-12

申请号：US14493231

申请日：2014-09-22

申请人： IONSENSE, INC

发明人： Brian D Musselman

IPC分类号： G01N27/62 ,  H01J27/02 ,  H01J49/04 ,  H01J49/10 ,  H01J49/00 ,  G01N1/22

CPC分类号： H01J49/10 ,  G01N1/2214 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/0409

摘要： In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container.

摘要翻译： 在本发明的各种实施例中，可以以适当的时间间隔来监视货物集装箱，以确定货物在集装箱中没有运送受控物质。 监测利用从大气分析仪产生的反应物质电离存在于容器中的分析物分子，然后通过合适的光谱系统进行分析。 在本发明的一个实施方案中，可以使用吸附剂表面来吸收，吸附或冷凝容器内的分析物分子，然后可以用反应性物质询问吸附剂表面以产生容器内容物特征的分析物质。

公开(公告)号：US08895916B2

公开(公告)日：2014-11-25

申请号：US14279644

申请日：2014-05-16

申请人： Ionsense, Inc

发明人： Brian D Musselman

IPC分类号： G01N27/62 ,  H01J27/02

CPC分类号： H01J49/10 ,  G01N1/2214 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/0409

摘要： In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container.

摘要翻译： 在本发明的各种实施例中，可以以适当的时间间隔来监视货物集装箱，以确定货物在集装箱中没有运送受控物质。 监测利用从大气分析仪产生的反应物质电离存在于容器中的分析物分子，然后通过合适的光谱系统进行分析。 在本发明的一个实施方案中，可以使用吸附剂表面来吸收，吸附或冷凝容器内的分析物分子，然后可以用反应性物质询问吸附剂表面以产生容器内容物特征的分析物质。

公开(公告)号：US20190371592A1

公开(公告)日：2019-12-05

申请号：US16422339

申请日：2019-05-24

申请人： IonSense Inc.

发明人： Brian D Musselman

IPC分类号： H01J49/14

摘要： In an embodiment of the present ambient ionization experiment, the abundance of background chemicals relative to ions of interest is decreased by reducing the overall abundance of background chemicals introduced into the ionizing region. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by limiting the area which the sample volume is deposited. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by decreasing the duration of time that the sample is exposed to the atmospheric pressure ionization source. In an embodiment of the present invention, the reduction of unwanted background chemicals in the ionization region can be effected by limiting the sample volume. In an embodiment of the present invention dilution of the sample with water can be used to reduce the contribution of the background chemicals. In an embodiment of the present ambient ionization experiment, an ion intensifier is used to suppress ionization of background chemicals to permit more efficient ionization and detection of the molecules of interest.

公开(公告)号：US10056243B2

公开(公告)日：2018-08-21

申请号：US15812913

申请日：2017-11-14

申请人： IONSENSE INC.

发明人： Brian D Musselman

IPC分类号： H01J49/00 ,  H01J49/16 ,  H01J49/04

CPC分类号： H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

摘要： The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

公开(公告)号：US09633827B2

公开(公告)日：2017-04-25

申请号：US15081459

申请日：2016-03-25

申请人： IONSENSE INC.

发明人： Brian D Musselman

IPC分类号： H01J49/10 ,  H01J49/00 ,  G01N27/62 ,  B01D59/44 ,  H01J49/04 ,  G01N1/22

CPC分类号： H01J49/10 ,  G01N1/2214 ,  G01N27/62 ,  H01J49/0027 ,  H01J49/0409

摘要： In various embodiments of the invention, a cargo container can be monitored at appropriate time intervals to determine that no controlled substances have been shipped with the cargo in the container. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present in the container which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules within the container whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the contents of the container.

公开(公告)号：US09224587B2

公开(公告)日：2015-12-29

申请号：US14589687

申请日：2015-01-05

申请人： IONSENSE INC.

发明人： Jordan Krechmer ,  Brian D Musselman

IPC分类号： H01J49/04 ,  G01N27/62 ,  G01N27/64 ,  H01J49/24 ,  H01J49/10

CPC分类号： H01J49/049 ,  G01N27/622 ,  G01N27/626 ,  G01N27/64 ,  H01J27/26 ,  H01J49/004 ,  H01J49/04 ,  H01J49/0431 ,  H01J49/10 ,  H01J49/126 ,  H01J49/14 ,  H01J49/24 ,  Y10T436/24

摘要： The present invention is directed to a method and device to desorb an analyte using heat to allow desorption of the analyte molecules, where the desorbed analyte molecules are ionized with ambient temperature ionizing species. In various embodiments of the invention a current is passed through a mesh upon which the analyte molecules are present. The current heats the mesh and results in desorption of the analyte molecules which then interact with gas phase metastable neutral molecules or atoms to form analyte ions characteristic of the analyte molecules.