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1.发明授权公开(公告)号：US06878700B1
公开(公告)日：2005-04-12
申请号：US09541795
申请日：2000-03-31
申请人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00 , A61K31/33 , A61K31/415 , C07D221/02 , C07D265/30 , C07D319/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎性和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
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2.发明申请公开(公告)号：US20050250768A1
公开(公告)日：2005-11-10
申请号：US10921965
申请日：2004-08-20
申请人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。
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公开(公告)号：US06579882B2
公开(公告)日：2003-06-17
申请号：US09799729
申请日：2001-03-06
申请人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
发明人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
IPC分类号： A61K31519
CPC分类号： C07D493/04 , C07D495/04 , C07D513/04
摘要： Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
摘要翻译： 具有式Iare的化合物可用于治疗炎症。 还公开了包含式I化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。
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公开(公告)号：US06232320B1
公开(公告)日：2001-05-15
申请号：US09325336
申请日：1999-06-03
申请人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
发明人： Andrew O. Stewart , Steven A. Boyd , David L. Arendsen , Pramila Bhatia , Kevin R. Condroski , Jennifer C. Freeman , Indrani W. Gunawardana , Gui-Dong Zhu , Kraig Lartey , Catherine M. McCarty , Nicholas A. Mort , Meena V. Patel , Michael A. Staeger , David M. Stout
IPC分类号： A61K314365
CPC分类号： C07D493/04 , C07D495/04 , C07D513/04
摘要： Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
摘要翻译： 具有式Iare的化合物可用于治疗炎症。 还公开了包含式I化合物的药物组合物，以及哺乳动物抑制/治疗炎性疾病的方法。
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公开(公告)号：US08383624B2
公开(公告)日：2013-02-26
申请号：US12836637
申请日：2010-07-15
申请人： Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
发明人： Thomas D. Penning , Virajkumar B. Gandhi , Gui-Dong Zhu , Yunsong Tong , Keith W. Woods , Chunqiu Lai , Jane Gong , Alan S. Florjancic
IPC分类号： A61K31/495
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，X和Y在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US08383623B2
公开(公告)日：2013-02-26
申请号：US13086580
申请日：2011-04-14
申请人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
发明人： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC分类号： A01N43/58 , A61K31/50 , C07D237/30
CPC分类号： C07D471/04 , C07D401/04
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US08248191B2
公开(公告)日：2012-08-21
申请号：US12699248
申请日：2010-02-03
申请人： Guang-Ze Li , Gui-Dong Zhu
发明人： Guang-Ze Li , Gui-Dong Zhu
IPC分类号： H01P1/203
CPC分类号： H01P1/20354 , H01P1/20381 , H01P1/2039
摘要： A filter includes a circuit board, a low-pass filter circuit, and a high-pass filter circuit. The circuit board includes at least one metal layer, and a dielectric layer attached on the at least one metal layer. The low-pass filter circuit is defined in the metal layer, and includes a main line that has two parallel portions, and a modulating circuit serving as a capacitor connected to the main line of the low-pass filter circuit. The high-pass filter circuit defined in the metal layer includes a main line that has two parallel portions and is connected to the low-pass filter circuit, and a modulating circuit serving as a conductor connected to the main line of the high-pass filter circuit.
摘要翻译： 滤波器包括电路板，低通滤波器电路和高通滤波器电路。 电路板包括至少一个金属层和附着在至少一个金属层上的电介质层。 低通滤波器电路被限定在金属层中，并且包括具有两个平行部分的主线和用作连接到低通滤波器电路的主线的电容器的调制电路。 限定在金属层中的高通滤波器电路包括具有两个并联部分并连接到低通滤波器电路的主线，以及用作连接到高通滤波器的主线的导体的调制电路 电路。
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8.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂公开(公告)号：US20090186877A1
公开(公告)日：2009-07-23
申请号：US12413834
申请日：2009-03-30
申请人： Vincent L. Giranda , Thomas D. Penning , Virajkumar B. Gandhi , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong
发明人： Vincent L. Giranda , Thomas D. Penning , Virajkumar B. Gandhi , Sheela A. Thomas , Gui-Dong Zhu , Jianchun Gong
IPC分类号： A61K31/551 , C07D235/06 , A61K31/4184 , C07D403/02 , A61P35/00
CPC分类号： C07D403/10 , C07D235/18 , C07D409/04
摘要： The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
摘要翻译： 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。
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公开(公告)号：US20080108659A1
公开(公告)日：2008-05-08
申请号：US11867369
申请日：2007-10-04
IPC分类号： A61K31/454 , C07D401/00 , A61K31/4035 , A61P37/08 , A61P35/00 , A61P39/02 , A61K31/4025 , C07D209/44
CPC分类号： C07D209/44 , C07D209/46 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06
摘要： Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
摘要翻译： 公开了抑制聚（ADP-核糖）聚合酶活性的化合物，含有化合物的组合物和使用该化合物治疗疾病的方法。
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10.发明申请SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-羧酰胺是残留的PARP抑制剂公开(公告)号：US20070270476A1
公开(公告)日：2007-11-22
申请号：US11830318
申请日：2007-07-30
申请人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
发明人： Thomas Penning , Sheela Thomas , Gui-Dong Zhu , Jianchun Gong , Vincent Giranda , Viraj Gandhi
IPC分类号： A61K31/4164 , A61K31/426 , A61P29/00 , A61P31/04 , A61P35/00 , C07D235/04 , C07D277/20
CPC分类号： C07D235/18 , C07D409/04 , C07D413/04 , C07D417/04
摘要： Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
摘要翻译： 式（I）的化合物抑制PARP酶，并且可用于治疗与PARP相关的疾病或病症。 还公开了包含式（I）化合物，包含式（I）化合物的治疗方法的药物组合物，以及抑制包含式（I）化合物的PARP酶的方法。
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