-
公开(公告)号：USRE39197E1
公开(公告)日：2006-07-18
申请号：US10356794
申请日：2002-08-29
申请人： James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人： James T. Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号： A61K31/505 , A61K31/405 , C07D239/70 , C07D319/14 , C07D319/00
CPC分类号： C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
-
2.发明授权公开(公告)号：US06878700B1
公开(公告)日：2005-04-12
申请号：US09541795
申请日：2000-03-31
申请人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom von Geldern , Martin Winn , Zhili Xin , Steven A. Boyd , Gui-Dong Zhu , Jennifer C. Freeman , Indrani W. Gunawardana , Michael A. Staeger , Hwan-Soo Jae , John K. Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00 , A61K31/33 , A61K31/415 , C07D221/02 , C07D265/30 , C07D319/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immunune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎性和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
-
公开(公告)号：US06329534B1
公开(公告)日：2001-12-11
申请号：US09654322
申请日：2000-09-01
申请人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze
发明人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze
IPC分类号： C07D31180
CPC分类号： C07D407/04 , C07D311/80 , C07D409/04
摘要： Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 式I化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除率不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，化合物的制剂，含该化合物的组合物，以及使用该化合物的治疗方法。
-
公开(公告)号：US06436986B1
公开(公告)日：2002-08-20
申请号：US09635349
申请日：2000-08-09
IPC分类号： A61K3135
CPC分类号： C07D311/80
摘要： The instant invention relates to compounds of formula I which are useful as antagonists of the glucocorticoid receptor and for treating diabetes in a mammal. In addition, any glucocorticoid receptor antagonist(s) is useful for the treatment of diabetes.
摘要翻译： 本发明涉及式I化合物，其可用作糖皮质激素受体的拮抗剂并用于治疗哺乳动物的糖尿病。 此外，任何糖皮质激素受体拮抗剂可用于治疗糖尿病。
-
公开(公告)号：US06593480B2
公开(公告)日：2003-07-15
申请号：US09795998
申请日：2001-02-28
申请人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze , Kimba L. Ashworth , Kresna Hartandi
发明人： Philip R. Kym , Benjamin C. Lane , John K. Pratt , Tom Von Geldern , Martin Winn , Jehrod Brenneman , Jyoti R. Patel , David L. Arendsen , Irini Akritopoulou-Zanze , Kimba L. Ashworth , Kresna Hartandi
IPC分类号： C07D31180
CPC分类号： C07D407/04 , C07D311/80 , C07D409/04
摘要： Compounds of formula I are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 式I化合物可用于治疗II型糖尿病，肥胖症，高血糖症，葡萄糖清除率不足，高胰岛素血症，高甘油三酯血症和高循环糖皮质激素水平，化合物的制剂，含该化合物的组合物，以及使用该化合物的治疗方法。
-
6.发明授权
公开(公告)号：US6110922A
公开(公告)日：2000-08-29
申请号：US222491
申请日：1998-12-29
申请人： James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
发明人： James Link , Gang Liu , Zhonghua Pei , Tom von Geldern , Martin Winn , Zhili Xin
IPC分类号： C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10 , A61K31/505 , A61K31/405 , C07C319/00 , C07D239/70 , C07D319/14
CPC分类号： C07D207/27 , C07C323/62 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10 , C07C2101/02 , C07C2101/04 , C07C2101/08
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译： 本发明涉及可用于治疗炎性和免疫疾病的新颖的肉桂酰胺化合物，包含这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。
-
7.发明申请Novel glucocorticoid receptor ligands for the treatment of metabolic disorders 失效用于治疗代谢紊乱的新型糖皮质激素受体配体公开(公告)号：US20070027117A1
公开(公告)日：2007-02-01
申请号：US11491337
申请日：2006-07-21
申请人： Richard Bishop , Russell Cink , Bradley Gates , Lars Hagberg , Peer Jacobsen , Philip Kym , Chunqiu Lai , Marvin Leanna , James Link , Steven Richards , Noah Tu , Tom von Geldern
发明人： Richard Bishop , Russell Cink , Bradley Gates , Lars Hagberg , Peer Jacobsen , Philip Kym , Chunqiu Lai , Marvin Leanna , James Link , Steven Richards , Noah Tu , Tom von Geldern
CPC分类号： C07J1/00 , Y10S514/866 , Y10S514/909
摘要： This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.
摘要翻译： 本发明涉及作为肝脏选择性糖皮质激素受体拮抗剂的新型化合物，制备这些化合物的方法，以及使用这些化合物来调节代谢的方法，特别是降低血清葡萄糖水平，胰岛素水平或脂质水平，和/或 减轻体重。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.02 秒)
