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    Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin
    4.
    发明申请
    Process for providing a temperature-stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin 审中-公开
    在肉毒杆菌毒素的神经毒性成分的基础上提供温度稳定的肌肉松弛剂的方法

    公开(公告)号：US20090010965A1

    公开(公告)日：2009-01-08

    申请号：US12154982

    申请日：2008-05-29

    申请人： Karl-Heinz Eisele ,  Harold V. Taylor ,  Matthias Marx

    发明人： Karl-Heinz Eisele ,  Harold V. Taylor ,  Matthias Marx

    IPC分类号： A61K39/02

    CPC分类号： A61K9/0019 ,  A61K38/4893 ,  Y02A50/469

    摘要： The present invention provides a method for providing a muscle relaxant, wherein said muscle relaxant is a reconstituted solution comprising the neurotoxic component of botulinum toxin free of complexing proteins, which exhibits at least one of the following characteristics, more preferably all characteristics a) to d): a. Stable at storage temperatures above 20° C. b. Stable in the presence of preservatives and/or analgesics c. Resistant against “freeze and thaw”-cycles d. Stable if stored in containers of different material.

    摘要翻译： 本发明提供一种提供肌肉松弛剂的方法，其中所述肌肉松弛剂是包含不含络合蛋白的肉毒杆菌毒素的神经毒性成分的重构溶液，其表现出以下特征中的至少一个，更优选所有特征a）至d ）： 一个。 在高于20℃的储存温度下稳定。 在防腐剂和/或止痛剂存在下稳定c。 抵抗“冻融” - 循环d。 如果存放在不同材料的容器中，则稳定。

    Sheet-like reinforced material
    5.
    发明授权
    Sheet-like reinforced material 失效
    片状增强材料

    公开(公告)号：US4617225A

    公开(公告)日：1986-10-14

    申请号：US791113

    申请日：1985-10-24

    申请人： Peter Horn ,  Edwin Baumann ,  Matthias Marx ,  Peter Gerarts

    发明人： Peter Horn ,  Edwin Baumann ,  Matthias Marx ,  Peter Gerarts

    IPC分类号： B32B5/28 ,  B32B5/24 ,  B32B37/10 ,  B32B38/00 ,  C08G69/16 ,  C08J5/24 ,  B32B3/26 ,  B32B5/18 ,  B32B7/04 ,  B32B27/04

    CPC分类号： C08G69/16 ,  B32B5/24 ,  Y10T428/24967 ,  Y10T428/249955 ,  Y10T428/249981 ,  Y10T428/249991 ,  Y10T442/647

    摘要： Sheet-like reinforced materials consisting ofA. a core layer comprising a sheet-like textile structure, preferably a glass fiber mat,B. a plastic matrix composed of a nylon which has been polymerized under alkaline conditions and penetrates both the core layer and the surface layer of layers,are produced batchwise by the RIM method or continuously on a double-belt press by impregnating the sheet-line textile structure and the foam sheets with a lactam melt and polymerizing the latter. The reinforced material can be used for the production of finished articles having a satisfactory surface, for example for the automotive or aircraft industry.

    摘要翻译： 由A组成的片状增强材料，包括片状织物结构的芯层，优选玻璃纤维垫B.由尼龙组成的塑料基质，其在碱性条件下已经聚合并渗透到芯层和 通过RIM方法分批生产或在双带压榨机上连续地通过用内酰胺熔体浸渍片状织物结构和泡沫片材并使其聚合而分批生产层。 增强材料可以用于生产具有令人满意的表面的成品，例如用于汽车或飞机工业。

    Liquid, urea group-containing polyisocyanate mixtures
    6.
    发明授权
    Liquid, urea group-containing polyisocyanate mixtures 失效
    液态，含脲基的多异氰酸酯混合物

    公开(公告)号：US4611083A

    公开(公告)日：1986-09-09

    申请号：US674077

    申请日：1984-11-23

    申请人： Ingolf Buethe ,  Matthias Marx ,  Willibald Schonleben

    发明人： Ingolf Buethe ,  Matthias Marx ,  Willibald Schonleben

    IPC分类号： C07C265/12 ,  C07C275/28 ,  C08G18/32 ,  C08G18/42 ,  C08G18/44 ,  C08G18/48 ,  C08G18/50 ,  C08G18/56 ,  C08G18/60 ,  C08G18/72 ,  C08G18/78 ,  C08G18/80 ,  C08L75/00 ,  C08L75/04 ,  C07C119/048

    CPC分类号： C07C265/12 ,  C07C275/28 ,  C08G18/3228 ,  C08G18/5024 ,  C08G18/7825 ,  C08G18/8038

    摘要： The invention relates to urea group-containing polyisocyanate mixtures which are liquid at room temperature and have an isocyanate group content of from 15 to 30 weight percent and a diphenylmethane diisocyanate content of from 55 to 90 weight percent, obtained through the reaction of(A) polyoxyalkylene polyamines having a functionality of from 2 to 5 and an amine number from 20 to 250 with a polyisocyanate (B) selected from the group consisting of(B1) a mixture of diphenylmethane diisocyanates and polyphenyl polymethylene polyisocyanates having a diphenylmethane diisocyanate content of from 55 to 90 weight percent or(B2) at least one diphenylmethane diisocyanate isomer.The polyisocyanate mixtures claimed in the invention are used to prepare dense or cellular polyurethane and/or polyisocyanurate plastics, in particular, flexible polyurethane foams.

    摘要翻译： 本发明涉及含有脲基的多异氰酸酯混合物，其在室温下为液体，异氰酸酯基含量为15〜30重量％，二苯基甲烷二异氰酸酯含量为55〜90重量％，通过（A） 具有2至5的官能度和20至250的胺数的聚氧化烯多胺与选自（B1）二苯基甲烷二异氰酸酯和聚苯基多亚甲基多异氰酸酯的混合物的多异氰酸酯（B）的二异氰酸酯含量为55 至90重量％或（B2）至少一种二苯基甲烷二异氰酸酯异构体。 本发明要求保护的多异氰酸酯混合物用于制备致密或细胞聚氨酯和/或聚异氰脲酸酯塑料，特别是柔性聚氨酯泡沫塑料。

    Process for the preparation of optionally cellular polyurethane polyurea molded parts
    7.
    发明授权
    Process for the preparation of optionally cellular polyurethane polyurea molded parts 失效
    制备任选细胞聚氨酯聚脲模制件的方法

    公开(公告)号：US4595705A

    公开(公告)日：1986-06-17

    申请号：US700758

    申请日：1985-02-13

    申请人： Frank Werner ,  Matthias Marx ,  Peter Horn ,  Hans U. Schmidt

    发明人： Frank Werner ,  Matthias Marx ,  Peter Horn ,  Hans U. Schmidt

    IPC分类号： C08G18/32 ,  C08G18/40 ,  C08G18/65 ,  C08G18/14 ,  C08G18/30

    CPC分类号： C08G18/6529 ,  C08G18/3221 ,  C08G18/4009 ,  C08G18/4018 ,  C08G2101/0033 ,  C08G2120/00 ,  Y10T428/249989

    摘要： The invention relates to a one-shot process for the preparation of cellular or noncellular polyurethane polyurea parts having a modulus of flexural elasticity greater than 600 N/mm.sup.2 and densities of from 0.8 to 1.2 g/cm.sup.3 using the reaction injection molding technique, by reacting organic polyisocyanates, a polyol component, aromatic diamines, additional chain extenders and/or cross-linking agents in the presence of catalysts and optionally blowing agents, auxiliaries and/or additives, wherein the polyol component is a mixture containing(i) from 95 to 60 percent by weight of at least one compound selected from the group consisting of polyols, polyether polyamines, polyesteramides, and their mixtures having functionalities of from 2 to 6 and a molecular weight of from 1000 to 8000 and(ii) from 5 to 40 percent by weight of a least one aromatic and/or aromatic-aliphatic polyester polyol having a functionality of from 2 to 3 and a molecular weight of from 254 to 700, wherein the percents by weight are based on the total weight of the polyol component.

    摘要翻译： 本发明涉及使用反应注射成型技术制备具有大于600N / mm2的弯曲弹性模量和0.8至1.2g / cm 3的密度的细胞或非细胞聚氨酯聚脲部件的一步法，通过使 有机多异氰酸酯，多元醇组分，芳族二胺，另外的增链剂和/或交联剂，在催化剂和任选的发泡剂，助剂和/或添加剂的存在下，其中多元醇组分是含有（i）95至 60重量％的至少一种选自多元醇，聚醚多胺，聚酯酰胺及其混合物的至少一种化合物，其官能度为2至6，分子量为1000至8000，（ii）5至40％ 的至少一种官能度为2至3且分子量为254至700的至少一种芳族和/或芳族 - 脂族聚酯多元醇，其中百分比 基于多元醇组分的总重量。

    Storage-stable tris(hydroxyalkyl)isocyanurate polyol dispersions, process for their preparation and their utilization
    8.
    发明授权
    Storage-stable tris(hydroxyalkyl)isocyanurate polyol dispersions, process for their preparation and their utilization 失效
    储存稳定的三（羟烷基）异氰脲酸酯多元醇分散体，其制备及其利用过程

    公开(公告)号：US4514526A

    公开(公告)日：1985-04-30

    申请号：US633512

    申请日：1984-07-23

    申请人： Matthias Marx ,  Helmut Ganss ,  Wolfram Frank

    发明人： Matthias Marx ,  Helmut Ganss ,  Wolfram Frank

    IPC分类号： C08G18/38 ,  C08G18/65 ,  C08G18/14

    CPC分类号： C08G18/65 ,  C08G18/3853 ,  C08G2105/02 ,  Y10S516/02

    摘要： The invention relates to storage-stable tris(hydroxyalkyl)isocyanurate polyol dispersions containing(a) from 2 to 70 parts by weight tris(hydroxyalkyl)isocyanurate,(b) from 98 to 30 parts by weight of at least one polyol having a functionality of from 2 to 8 and a hydroxyl number from 20 to 1800, and(c) from 0 to 20 parts by weight of one or more dispersion stabilizers.The dispersions are prepared by dissolving starting components A and B at temperatures in excess of 100.degree. C., in some cases adding a dispersion stabilizer and/or crystallization accelerator, with continuous and step-wise cooling of the mixture while stirring. The products are utilized for the preparation of polyurethane plastics, in particular polyisocyanurate foams containing polyurethane or polyurethane groups.

    摘要翻译： 本发明涉及含有（a）2-70重量份三（羟基烷基）异氰脲酸酯的储存稳定的三（羟烷基）异氰脲酸酯多元醇分散体，（b）98-30重量份至少一种具有官能度 2至8，羟基数为20至1800，和（c）0至20重量份的一种或多种分散稳定剂。 通过将起始组分A和B在超过100℃的温度下溶解，在一些情况下加入分散体稳定剂和/或结晶促进剂，同时在搅拌下连续和逐步冷却混合物来制备分散体。 该产品用于制备聚氨酯塑料，特别是含有聚氨酯或聚氨酯基团的聚异氰脲酸酯泡沫。

    Process for purification of crude polyether polyols
    9.
    发明授权
    Process for purification of crude polyether polyols 失效
    纯聚醚多元醇的纯化方法

    公开(公告)号：US4507475A

    公开(公告)日：1985-03-26

    申请号：US516330

    申请日：1983-07-22

    申请人： Wolfgang Straehle ,  Raymond Denni ,  Matthias Marx

    发明人： Wolfgang Straehle ,  Raymond Denni ,  Matthias Marx

    IPC分类号： C08G65/30 ,  C07H15/04 ,  C07C41/34

    CPC分类号： C08G65/30

    摘要： A process for purifying crude polyether polyols which are prepared by anionic polymerization of alkylene oxides in the presence of basic catalysts. The polyols are mixed with water and ortho-phosphoric acid in certain quantity ratios, an adsorption agent is incorporated in the reaction mixture, the mixture is filtered and the water is removed from the polyether polyol by distillation.

    摘要翻译： 在碱性催化剂存在下，通过环氧烷阴离子聚合制备粗制聚醚多元醇的方法。 多元醇以一定量的比例与水和正磷酸混合，将反应混合物中加入吸附剂，过滤混合物，并通过蒸馏从聚醚多元醇中除去水。