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公开(公告)号:US20080058247A1
公开(公告)日:2008-03-06
申请号:US11832019
申请日:2007-08-01
申请人: Jian Ni , Craig Rosen , Reiner Gentz
发明人: Jian Ni , Craig Rosen , Reiner Gentz
IPC分类号: A61K31/70 , A61K38/00 , A61P43/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N5/00 , G01N33/00
CPC分类号: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
摘要翻译: 公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。
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公开(公告)号:US20050119457A1
公开(公告)日:2005-06-02
申请号:US10314942
申请日:2002-12-10
申请人: Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
发明人: Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
IPC分类号: C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/735 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/50 , C07H21/04
CPC分类号: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体,宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US20080015149A1
公开(公告)日:2008-01-17
申请号:US11773491
申请日:2007-07-05
申请人: Jian Ni , Reiner Gentz , Craig Rosen , Fu-Tong Lui
发明人: Jian Ni , Reiner Gentz , Craig Rosen , Fu-Tong Lui
IPC分类号: A61K38/17 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07H21/04 , C07K14/435 , C07K16/18 , C12N15/63 , C12N5/10 , C12P21/00 , G01N33/53
CPC分类号: C12N9/6475 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/4726 , C07K14/705 , C07K14/70535 , C07K16/18 , C07K16/2851 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.
摘要翻译: 本发明涉及作为半乳凝素超家族成员的新型半乳凝素11蛋白。 特别地,提供了分离的核酸分子,其编码人galectin11蛋白。 还提供了Galectin11多肽,载体,宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定galectin11活性的激动剂和拮抗剂的筛选方法。 还提供诊断和治疗方法。
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公开(公告)号:US20060039905A1
公开(公告)日:2006-02-23
申请号:US11246980
申请日:2005-10-11
申请人: Jian Ni , Reiner Gentz , Craig Rosen , Fu-Tong Liu
发明人: Jian Ni , Reiner Gentz , Craig Rosen , Fu-Tong Liu
IPC分类号: C07K16/28 , C07K14/705 , C07H21/04 , C12P21/06 , A61K39/395
CPC分类号: C12N9/6475 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/4726 , C07K14/705 , C07K14/70535 , C07K16/18 , C07K16/2851 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel galectin 11 proteins which are members of the galectin superfamily. In particular, isolated nucleic acid molecules are provided encoding the human galectin 11 proteins. Galectin 11 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of galectin 11 activity. Also provided are diagnostic and therapeutic methods.
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公开(公告)号:US06878812B2
公开(公告)日:2005-04-12
申请号:US09950688
申请日:2001-09-13
申请人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
发明人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
IPC分类号: A61K38/00 , C07K14/47 , C07K14/705 , C07K14/735 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/57 , C07K16/00
CPC分类号: C12N9/6489 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译: 本发明涉及新型金属蛋白酶样蛋白质。 特别地,提供了分离的核酸分子,其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体,宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。
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公开(公告)号:US06312937B1
公开(公告)日:2001-11-06
申请号:US09372154
申请日:1999-08-11
申请人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
发明人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
IPC分类号: C12N950
CPC分类号: C12N9/6489 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译: 本发明涉及新型金属蛋白酶样蛋白质。 特别地,提供了分离的核酸分子,其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体,宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。
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公开(公告)号:US6046031A
公开(公告)日:2000-04-04
申请号:US9156
申请日:1998-01-20
申请人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
发明人: Jian Ni , Steve Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
IPC分类号: A61K38/00 , C07K14/47 , C07K14/705 , C07K14/735 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/57 , C12P21/06
CPC分类号: C12N9/6489 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , A61K38/00 , C12N2799/026
摘要: The present invention relates to novel metalloproteinase-like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译: 本发明涉及新型金属蛋白酶样蛋白质。 特别地,提供了分离的核酸分子,其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体,宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。
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公开(公告)号:US20070238130A1
公开(公告)日:2007-10-11
申请号:US11627246
申请日:2007-01-25
申请人: Jian Ni , Steven Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
发明人: Jian Ni , Steven Ruben , Laurie Brewer , Reiner Gentz , Craig Rosen
CPC分类号: C12N9/6489 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70535 , C12N9/00 , C12N9/6475 , C12N9/6491 , C12N2799/026
摘要: The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TACE-like and matrilysin-like activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of these metalloproteinases.
摘要翻译: 本发明涉及新型金属蛋白酶样蛋白质。 特别地,提供了分离的核酸分子,其编码人类TACE样和基质溶素样蛋白。 TACE样和基质溶素样多肽也可以作为载体,宿主细胞和用于制备它们的重组方法提供。 本发明进一步涉及用于鉴定TACE样和基质溶素样活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及特征在于这些金属蛋白酶过度或过量生产的其它病症。
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公开(公告)号:US20050244857A1
公开(公告)日:2005-11-03
申请号:US11076187
申请日:2005-03-10
申请人: Jian Ni , Craig Rosen , James Pan , Reiner Gentz , Vishva Dixit
发明人: Jian Ni , Craig Rosen , James Pan , Reiner Gentz , Vishva Dixit
IPC分类号: C12N15/09 , C07H21/04 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/06 , C12Q1/68
CPC分类号: C07K14/70578
摘要: The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
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公开(公告)号:US20050233958A1
公开(公告)日:2005-10-20
申请号:US10979831
申请日:2004-11-03
申请人: Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig Rosen
发明人: Jian Ni , Reiner Gentz , Guo-Liang Yu , Craig Rosen
IPC分类号: A61K38/00 , A61K38/17 , C07K14/705 , C07K16/28
CPC分类号: C07K16/2878 , A61K38/00 , C07K14/70578 , C07K2317/622 , C07K2319/30
摘要: The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR5, which may be agonists and/or antagonists of DR5 activity.
摘要翻译: 本发明涉及作为肿瘤坏死因子(TNF)受体家族的成员的新的含有死亡域的受体-5(DR5)蛋白,现在已经显示结合TRAIL。 特别地,提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽,载体,宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。 本发明还涉及使用DR5特异性抗体(其可以是DR5活性的激动剂和/或拮抗剂)的减少或增加的细胞凋亡相关疾病的治疗。
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