摘要:
The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate. The activity and stability of the entrapped membrane-associated molecule was significantly improved in macroporous silica.
摘要:
The present invention includes polyol modified titanium compounds, their preparation and use in methods to make biomolecule compatible monolithic titania. The invention also includes the use of the biomolecule compatible monolithic titania in bioanalytic applications, for example in biosensors, chromatographic columns, microarrays and bioaffinity columns.
摘要:
Siliceous materials were prepared by adding one or more additives, including one or more water soluble polymers, and derivatives thereof, as well as trifunctional silanes, to sols containing tetraalkoxysilanes derived from polyols. The polymers facilitate phase separation of the growing silica gel matrix, leading to high surface area self-supporting silica gels with cure occurring at ambient temperatures. The materials also show a significant reduction in shrinkage properties and significant protein stabilization abilities.
摘要:
The present invention relates to a two-step method of preparing methylsilsequixane (MSQ) materials suitable for chromatographic applications comprising treating a MSQ precursor with a suitable acid followed by treatment with a suitable base under conditions to form a MSQ monolith suitable for chromatographic applications.
摘要:
The present disclosure describes compounds of Formula (I) wherein m is 1 to 6, n is 6 to 10 and R1 is a straight or branch chain siloxane, their use in methods to modify the surface of hydrophobic substrates to render the substrates superhydrophilic and surface-modified substrates.
摘要:
A photo-responsive delivery system useful to deliver a compound to a target site is provided. The system includes a physiologically compatible matrix crosslinked with a photo-responsive matrix cross-linking agent. A method of making the delivery system and a method of delivering a compound to a target site using the system are also provided.
摘要:
The disclosure includes methods for preparing organosilicon-containing 1,2,3-triazoles by reacting an organosilicon containing azide with an alkyne compound or an organosilicon containing alkyne with an azide compound under thermal reaction conditions.
摘要:
The present disclosure relates to water-soluble stable gold nanoparticles (AuNPs) and methods for making the same. The present disclosure also includes the use of AuNPs, for example, in biological, medical and environmental assays for the detection of analytes, as well as biological and medical imaging.
摘要:
A particulate carrier for an agent comprising a solid core of a polysaccharide and a proteinaceous material and an organometallic polymer bonded to the core is provided. The agent has a biological activity, such as immunogenicity, and may comprise the proteinaceous material or be a separate component of the core. Polysaccharide cores include dextran, starch, cellulose and derivatives thereof and the organometallic polymer includes silicones including substituted silicones. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral administration to produce immune responses, including antibody responses.
摘要:
The present disclosure describes compounds of Formula (I) wherein m is 1 to 6, n is 6 to 10 and R1 is a straight or branch chain siloxane, their use in methods to modify the surface of hydrophobic substrates to render the substrates superhydrophilic and surface-modified substrates.