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    Virus-interacting layered phyllosilicates and methods of inactivating viruses in the gastrointestinal tract
    2.
    发明申请
    Virus-interacting layered phyllosilicates and methods of inactivating viruses in the gastrointestinal tract 审中-公开
    病毒相互作用的层状页硅酸盐和灭活胃肠道病毒的方法

    公开(公告)号：US20070231412A1

    公开(公告)日：2007-10-04

    申请号：US11641639

    申请日：2006-12-18

    申请人： John Hughes ,  Panayiotis Constantinides ,  Jerald Darlington

    发明人： John Hughes ,  Panayiotis Constantinides ,  Jerald Darlington

    IPC分类号： A61K48/00 ,  A61K33/06 ,  A61K33/12 ,  A61K33/38

    CPC分类号： C09C1/42 ,  A01N59/00 ,  A01N59/06 ,  C01P2004/20 ,  C01P2004/61

    摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein is a method of inactivating a virus in the gastrointestinal tract of a mammalian subject comprising administering to said subject a composition comprising a layered phyllosilicate material in an amount effective for virus inactivation. Also provided are methods of treating a viral infection in the gastrointestinal tract of a mammalian subject. Methods of delivering a therapeutic agent to a mammalian subject and methods of inactivating a virus in waste expelled from a mammal are also provided.

    摘要翻译： 层状页硅酸盐可用于吸附和/或结合病毒，从而使病毒失活。 因此，本文提供的是灭活哺乳动物受试者的胃肠道中的病毒的方法，包括向所述受试者施用含有有效用于病毒灭活的量的层状页硅酸盐材料的组合物。 还提供了治疗哺乳动物受试者的胃肠道中的病毒感染的方法。 还提供了向哺乳动物受试者递送治疗剂的方法和从哺乳动物排出的废物中灭活病毒的方法。

    Virus-interacting layered phyllosilicates and methods of inactivating viruses on animate and inanimate surfaces
    3.
    发明申请
    Virus-interacting layered phyllosilicates and methods of inactivating viruses on animate and inanimate surfaces 审中-公开
    病毒相互作用的层状页硅酸盐和在动画和无生命表面上灭活病毒的方法

    公开(公告)号：US20070224293A1

    公开(公告)日：2007-09-27

    申请号：US11641319

    申请日：2006-12-18

    申请人： John Hughes ,  Jerald Darlington ,  Panayiotis Constantinides

    发明人： John Hughes ,  Jerald Darlington ,  Panayiotis Constantinides

    IPC分类号： A61K33/12 ,  A61K33/06

    CPC分类号： C09C1/42 ,  A01N59/00 ,  A01N59/06 ,  C01P2004/20 ,  C01P2004/61

    摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein is a method of inhibiting transfer of a virus to a surface comprising contacting the surface with a composition comprising a layered phyllosilicate material in an amount sufficient for inhibiting the transfer of the virus thereto. Also provided are methods of inactivating a virus on a surface comprising contacting the surface with a composition comprising a layered phyllosilicate material in an amount sufficient to inactivate said virus.

    摘要翻译： 层状页硅酸盐可用于吸附和/或结合病毒，从而灭活病毒。 因此，本文提供了一种抑制病毒转移到表面的方法，包括使表面与包含层状页硅酸盐材料的组合物接触，所述组合物的量足以抑制病毒转移到其上。 还提供了使表面灭活病毒的方法，包括使表面与含有足以灭活所述病毒的量的层状页硅酸盐材料的组合物接触。

    Monoterpene compositions and uses thereof
    4.
    发明申请
    Monoterpene compositions and uses thereof 审中-公开
    单萜组合物及其用途

    公开(公告)号：US20060104997A1

    公开(公告)日：2006-05-18

    申请号：US10498566

    申请日：2002-12-11

    申请人： Panayiotis Constantinides ,  Reena Patil ,  Elijah Bolotin ,  Likan Liang

    发明人： Panayiotis Constantinides ,  Reena Patil ,  Elijah Bolotin ,  Likan Liang

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K31/337 ,  A61K31/11 ,  A61K31/045

    CPC分类号： A61K9/4858 ,  A61K9/1075 ,  A61K31/045 ,  A61K31/11 ,  A61K31/337 ,  A61K47/10 ,  A61K47/22

    摘要： The present invention relates to pharmaceutical compositions and methods for the mucosal and oral administration of monoterpenes and derivatives thereof. The compositions of this invention further comprise one or more surfactants and cosolvents and are in the form of self-emulsifying compositions. The compositions of the invention may further comprise water-insoluble therapeutic agents, vaccines and diagnostics. Such agents include but are not limited to taxanes, steroids, topoisomerase inhibitors such as etoposide and other water-insoluble or lipophilic drugs.

    摘要翻译： 本发明涉及用于粘膜和口服单萜及其衍生物的药物组合物和方法。 本发明的组合物还包含一种或多种表面活性剂和助溶剂，并且是自乳化组合物的形式。 本发明的组合物还可包含水不溶性治疗剂，疫苗和诊断。 这些试剂包括但不限于紫杉烷类，类固醇类，拓扑异构酶抑制剂如依托泊苷和其他水不溶性或亲脂性药物。

    Lipid particles and suspensions and uses thereof
    6.
    发明申请
    Lipid particles and suspensions and uses thereof 审中-公开
    脂质颗粒和悬浮液及其用途

    公开(公告)号：US20060078618A1

    公开(公告)日：2006-04-13

    申请号：US10498572

    申请日：2002-12-11

    申请人： Panayiotis Constantinides ,  Reena Patil ,  Likan Liang

    发明人： Panayiotis Constantinides ,  Reena Patil ,  Likan Liang

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1075 ,  A61K9/0019 ,  A61K9/127

    摘要： The present invention relates to formulations and methods for the mucosal and parenteral administration of lipid particles an suspensions. The formulations of this invention are stable lipid particles useful for oral delivery of water-insoluble therapeutic agents, vaccines and diagnostics. The compositions of this invention promote the mucosal absorption of biologically active molecules across mucosal epithelial barriers. Stabilization of lipid particles is achieved by coating the hydrophobic central core with a polymer shell. The polymer shell can include bioadhesive agents, ligands, and absorption promoting agents. This invention relates to oral drug delivery systems for hydrophobic drugs, and in particular is concerned with improving the bioavailability of hydrophobic drugs from such systems. Using this system, anticancer drugs such as taxanes are orally effective.

    摘要翻译： 本发明涉及用于粘膜和肠胃外给予脂质颗粒悬浮液的制剂和方法。 本发明的制剂是用于口服递送水不溶性治疗剂，疫苗和诊断的稳定的脂质颗粒。 本发明的组合物促进生物活性分子穿过粘膜上皮屏障的粘膜吸收。 脂质颗粒的稳定通过用聚合物壳涂覆疏水性中心核来实现。 聚合物壳可以包括生物粘附剂，配体和吸收促进剂。 本发明涉及用于疏水药物的口服药物递送系统，并且特别涉及提高来自这种系统的疏水性药物的生物利用度。 使用该系统，抗癌药如紫杉烷是口服有效的。

    Stabilized reverse micelle compositions and uses thereof
    8.
    发明申请
    Stabilized reverse micelle compositions and uses thereof 有权
    稳定的反胶束组合物及其用途

    公开(公告)号：US20050079145A1

    公开(公告)日：2005-04-14

    申请号：US10497775

    申请日：2002-12-03

    申请人： Panayiotis Constantinides ,  Likan Liang ,  Eun-Hyun Jang

    发明人： Panayiotis Constantinides ,  Likan Liang ,  Eun-Hyun Jang

    IPC分类号： A61K8/14 ,  A61K9/107 ,  A61K9/48 ,  A61K31/727 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61K47/34 ,  A61K47/48 ,  A61Q19/00 ,  A61K7/06 ,  A61K7/075 ,  A61K7/08 ,  A61K7/11

    CPC分类号： A61K31/727 ,  A61K8/0291 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/4891 ,  A61K38/09 ,  A61K38/23 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61Q19/00

    摘要： The invention relates to compositions and methods for drug delivery suitable for promoting the transmucosal absorption of drugs, especially drugs with poor intrinsic bioavailability, such as peptides, proteins, vaccines, and nucleic acids. The delivery system of this invention preferably comprises fatty acid esters and their hydrophilic derivatives that associate with water and other polar solvents to form reverse micelles tha are physically stabilized in the presence of gastrointestinal fluid, water, and other hydrophilic solvents. Such stable reverse micelles are formed by suitable mixtures of polymeric or non-polymeric compounds with amphiphiles. Micelles made using these methods undergo phase transformation more slowly resulting in delayed drug release profiles and sustained absorption. When administered as a pharmaceutical to mucosal surfaces following oral ingestion or intranasal administration, therapeutic molecules principally solubilized in the aqueous phase are protected from digestion by mucosal enzymes and other mucosal degradative processes and are taken up by absorptive cell mechanisms and reach appropriate body compartments. The reverse micelle compositions may comprise mono-, di-glycerides and/or their transesterifed products containing C6-C12 fatty acids chains, wherein the transester groups consist of hydrohilic moieties.

    摘要翻译： 本发明涉及用于药物递送的组合物和方法，其适用于促进药物，特别是具有差的内在生物利用度的药物（例如肽，蛋白质，疫苗和核酸）的经粘膜吸收。 本发明的递送系统优选包含与水和其它极性溶剂缔合以形成反胶束的脂肪酸酯及其亲水性衍生物，其在胃肠液，水和其它亲水溶剂存在下物理稳定。 这种稳定的反胶束由聚合物或非聚合物与两亲物的合适混合物形成。 使用这些方法制备的胶束进行相变更慢，导致延迟的药物释放曲线和持续吸收。 当口服摄取或鼻内给药后作为药物施用于粘膜表面时，主要溶解在水相中的治疗分子被保护不被粘膜酶和其它粘膜降解过程消化，并被吸收细胞机制吸收并达到适当的身体隔室。 反胶束组合物可以包含含有C6-C12脂肪酸链的单 - ，二 - 甘油酯和/或其酯交换产物，其中酯基组由亲水部分组成。