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    Hydroxylated contrast enhancement agents
    3.
    发明授权
    Hydroxylated contrast enhancement agents 失效
    羟基化对比增强剂

    公开(公告)号：US08378134B2

    公开(公告)日：2013-02-19

    申请号：US12570705

    申请日：2009-09-30

    申请人： Brian James Grimmond ,  Michael Todd Luttrell ,  Jeannette Christine DePuy ,  Mary Elizabeth Spilker ,  Michael James Rishel

    发明人： Brian James Grimmond ,  Michael Todd Luttrell ,  Jeannette Christine DePuy ,  Mary Elizabeth Spilker ,  Michael James Rishel

    IPC分类号： C07F15/00 ,  C07D225/00

    CPC分类号： A61K49/103 ,  C07C229/16 ,  C07C229/76

    摘要： In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I wherein R1 is independently at each occurrence a hydroxy group, a C1-C3hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3hydroxyalkyl group; and wherein Q is a charge balancing counterion. Also provided is a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement I.

    摘要翻译： 一方面，本发明提供一种对比度增强剂，其包含具有结构I的铁螯合物，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1-C3烷基，b为0-4 ; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是电荷平衡抗衡离子。 还提供了具有结构IX的金属螯合配体和包含对比度增强I的医学制剂。

    NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF
    6.
    发明申请
    NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF 有权
    纳米材料组合物及其相关方法

    公开(公告)号：US20120156141A1

    公开(公告)日：2012-06-21

    申请号：US12968577

    申请日：2010-12-15

    申请人： Bruce Allan Hay ,  Brian Christopher Bales ,  Michael Todd Luttrell ,  Binil Itty Ipe Kandapallil

    发明人： Bruce Allan Hay ,  Brian Christopher Bales ,  Michael Todd Luttrell ,  Binil Itty Ipe Kandapallil

    IPC分类号： A61K49/18 ,  A61P35/00 ,  B82Y30/00

    CPC分类号： A61K49/1842 ,  A61K49/1845 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

    摘要： A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

    摘要翻译： 提供纳米颗粒组合物，其中所述组合物包含纳米颗粒金属氧化物; 和包含至少两个磷酸酯基团的磷酸化多元醇。 多元醇包含一个或多个选自聚乙烯醚部分，聚丙烯醚部分，聚丁烯醚部分以及前述亲水部分中两个或更多个的组合的亲水基团。 还提供了制备纳米颗粒组合物的方法。 本发明提供的纳米颗粒组合物可用作医学成像技术如X射线和磁共振成像中的造影剂。

    Intermediates for Hydroxylated Contrast Enhancement Agents
    7.
    发明申请
    Intermediates for Hydroxylated Contrast Enhancement Agents 审中-公开
    羟基对比增强剂中间体

    公开(公告)号：US20110077417A1

    公开(公告)日：2011-03-31

    申请号：US12614729

    申请日：2009-11-09

    申请人： Brian James Grimmond ,  Michael James Rishel ,  Michael Todd Luttrell

    发明人： Brian James Grimmond ,  Michael James Rishel ,  Michael Todd Luttrell

    IPC分类号： C07D319/08 ,  C07F15/02 ,  C07C69/003

    CPC分类号： C07F7/1896 ,  C07D319/08 ,  C07F7/1804 ,  Y02P20/55

    摘要： In one aspect, the present invention provides a protected ligand precursor having structure XXI wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence acid sensitive protecting groups.

    摘要翻译： 一方面，本发明提供了具有结构XXI的受保护配体前体，其中R8在每次出现时独立地为保护的羟基，被保护的C 1 -C 3羟烷基或C 1 -C 3烷基，b为0-4; R 9 -R 11在每次出现时独立地为氢，被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基，条件是R 8 -R 11中的至少一个为被保护的羟基或被保护的C 1 -C 3羟烷基 ; R12和R13各自独立地存在酸敏感的保护基。

    AROMATIC HALOSULFONYL ISOCYANATE COMPOSITIONS
    9.
    发明申请
    AROMATIC HALOSULFONYL ISOCYANATE COMPOSITIONS 审中-公开
    芳香族卤代烷基异氰酸酯组合物

    公开(公告)号：US20090242479A1

    公开(公告)日：2009-10-01

    申请号：US12056415

    申请日：2008-03-27

    申请人： Gary William Yeager ,  Michael Todd Luttrell ,  Jiang Ji

    发明人： Gary William Yeager ,  Michael Todd Luttrell ,  Jiang Ji

    IPC分类号： B01D39/00 ,  C08G18/00

    CPC分类号： B01D69/08 ,  B01D61/025 ,  B01D67/0006 ,  B01D69/125 ,  B01D71/54 ,  B01D71/66 ,  B01D2323/40 ,  C08G18/3234 ,  C08G18/325 ,  C08G18/711 ,  C08G18/712 ,  C08G18/715 ,  C09D175/02 ,  C09D175/04

    摘要： The present invention provides a polymer composition comprising structural units derived from an aromatic halosulfonyl isocyanate having structure I wherein “m” is an integer from 2 to 5; “n” is an integer from 1 to 5; Ar is a C3-C40 aromatic radical which is free of aliphatic carbon-hydrogen bonds; and X is halogen. The polymer composition comprising aromatic halosulfonyl isocyanate are useful as membranes. In addition the present invention provides a separation membrane comprising a polymer composition comprising structural units derived from the aromatic halosulfonyl isocyanate having structure I.

    摘要翻译： 本发明提供一种聚合物组合物，其包含衍生自具有结构I的芳族卤代磺酰基异氰酸酯的结构单元，其中“m”为2至5的整数; “n”是1至5的整数; Ar是不含脂肪族碳氢键的C3-C40芳族基团; X为卤素。 包含芳族卤代磺酰基异氰酸酯的聚合物组合物可用作膜。 此外，本发明提供了一种分离膜，其包含聚合物组合物，其包含衍生自具有结构I的芳族卤代磺酰基异氰酸酯的结构单元。

    Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells
    10.
    发明授权
    Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells 有权
    具有PEG取代的α-羟基膦酸酯壳的超顺磁性纳米颗粒

    公开(公告)号：US09474810B2

    公开(公告)日：2016-10-25

    申请号：US13411004

    申请日：2012-03-02

    申请人： Bruce Allan Hay ,  Daniel Eugene Meyer ,  Brian Christopher Bales ,  Michael Todd Luttrell

    发明人： Bruce Allan Hay ,  Daniel Eugene Meyer ,  Brian Christopher Bales ,  Michael Todd Luttrell

    IPC分类号： A61K49/18 ,  A61K47/48 ,  A61K33/26 ,  A61K33/28 ,  A61K33/24 ,  A61K33/32 ,  A61K33/34

    CPC分类号： A61K49/186 ,  A61K33/24 ,  A61K33/26 ,  A61K33/32 ,  A61K33/34 ,  A61K47/548 ,  A61K47/60 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1842 ,  Y10T428/2982

    摘要： The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an α-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.

    摘要翻译： 本申请公开了纳米颗粒，特别是超顺磁性氧化铁的纳米颗粒，其可用于铁疗法和诸如磁共振（MR）的诊断成像。 所公开的纳米颗粒已经用含有聚乙二醇作为亲水部分的α-羟基膦酸缀合物进行处理，以使纳米颗粒充分亲水以发现在诊断成像中的应用。 所公开的改性亲水性纳米粒子是其中改性缀合物的亲水部分是聚环氧乙烷基聚合物并具有大于5,000道尔顿且小于或等于约30,000道尔顿的分子量的那些。 令人惊讶的是，与其中基于PEG的亲水部分具有小于5,000的分子量的类似纳米颗粒相比，这些纳米颗粒在保留的纳米颗粒的肝中具有更快速和完整的加工。