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    Hydroxylated contrast enhancement agents
    1.
    发明授权
    Hydroxylated contrast enhancement agents 失效
    羟基化对比增强剂

    公开(公告)号：US08378134B2

    公开(公告)日：2013-02-19

    申请号：US12570705

    申请日：2009-09-30

    申请人： Brian James Grimmond ,  Michael Todd Luttrell ,  Jeannette Christine DePuy ,  Mary Elizabeth Spilker ,  Michael James Rishel

    发明人： Brian James Grimmond ,  Michael Todd Luttrell ,  Jeannette Christine DePuy ,  Mary Elizabeth Spilker ,  Michael James Rishel

    IPC分类号： C07F15/00 ,  C07D225/00

    CPC分类号： A61K49/103 ,  C07C229/16 ,  C07C229/76

    摘要： In one aspect, the present invention provides a contrast enhancement agent comprising an iron chelate having structure I wherein R1 is independently at each occurrence a hydroxy group, a C1-C3hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3hydroxyalkyl group; and wherein Q is a charge balancing counterion. Also provided is a metal chelating ligand having structure IX and medical formulations comprising the contrast enhancement I.

    摘要翻译： 一方面，本发明提供一种对比度增强剂，其包含具有结构I的铁螯合物，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1-C3烷基，b为0-4 ; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是电荷平衡抗衡离子。 还提供了具有结构IX的金属螯合配体和包含对比度增强I的医学制剂。

    Intermediates for Hydroxylated Contrast Enhancement Agents
    3.
    发明申请
    Intermediates for Hydroxylated Contrast Enhancement Agents 审中-公开
    羟基对比增强剂中间体

    公开(公告)号：US20110077417A1

    公开(公告)日：2011-03-31

    申请号：US12614729

    申请日：2009-11-09

    申请人： Brian James Grimmond ,  Michael James Rishel ,  Michael Todd Luttrell

    发明人： Brian James Grimmond ,  Michael James Rishel ,  Michael Todd Luttrell

    IPC分类号： C07D319/08 ,  C07F15/02 ,  C07C69/003

    CPC分类号： C07F7/1896 ,  C07D319/08 ,  C07F7/1804 ,  Y02P20/55

    摘要： In one aspect, the present invention provides a protected ligand precursor having structure XXI wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence acid sensitive protecting groups.

    摘要翻译： 一方面，本发明提供了具有结构XXI的受保护配体前体，其中R8在每次出现时独立地为保护的羟基，被保护的C 1 -C 3羟烷基或C 1 -C 3烷基，b为0-4; R 9 -R 11在每次出现时独立地为氢，被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基，条件是R 8 -R 11中的至少一个为被保护的羟基或被保护的C 1 -C 3羟烷基 ; R12和R13各自独立地存在酸敏感的保护基。

    INTERMEDIATES FOR HYDROXYLATED CONTRAST ENHANCEMENT AGENTS
    4.
    发明申请
    INTERMEDIATES FOR HYDROXYLATED CONTRAST ENHANCEMENT AGENTS 审中-公开
    羟基对比增强剂的中间体

    公开(公告)号：US20110077396A1

    公开(公告)日：2011-03-31

    申请号：US12785110

    申请日：2010-05-21

    申请人： Brian James Grimmond ,  Michael James Rishel ,  Michael Todd Luttrell

    发明人： Brian James Grimmond ,  Michael James Rishel ,  Michael Todd Luttrell

    IPC分类号： C07F15/02 ,  C07D319/08 ,  C07C229/36 ,  C07F7/18 ,  C07C215/20

    CPC分类号： A61K49/103

    摘要： In one aspect, the present invention provides a protected ligand precursor having structure XX wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence a protecting group is selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, and C2-C30 aromatic radicals.

    摘要翻译： 一方面，本发明提供具有结构XX的保护配体前体，其中R8在每次出现时独立地为保护的羟基，受保护的C1-C3羟烷基或C1-C3烷基，b为0-4; R 9 -R 11在每次出现时独立地为氢，被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基，条件是R 8 -R 11中的至少一个为被保护的羟基或被保护的C 1 -C 3羟烷基 ; 并且R 12和R 13在每次出现时独立地为保护基团，选自C 1 -C 30脂族基，C 3 -C 30环脂族基和C 2 -C 30芳族基。

    HEAT STABLE NANOPARTICLE PREPARATIONS AND ASSOCIATED METHODS THEREOF
    6.
    发明申请
    HEAT STABLE NANOPARTICLE PREPARATIONS AND ASSOCIATED METHODS THEREOF 有权
    热稳定的纳米材料制备及其相关方法

    公开(公告)号：US20140003997A1

    公开(公告)日：2014-01-02

    申请号：US13538493

    申请日：2012-06-29

    申请人： Brian Christopher Bales ,  Brian James Grimmond ,  Daniel Eugene Meyer ,  Bruce Allan Hay ,  Michael Todd Luttrell

    发明人： Brian Christopher Bales ,  Brian James Grimmond ,  Daniel Eugene Meyer ,  Bruce Allan Hay ,  Michael Todd Luttrell

    IPC分类号： A61L2/04 ,  B82Y5/00 ,  B82Y40/00

    CPC分类号： H01F1/0054 ,  A61K49/1842 ,  A61K49/186 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

    摘要： A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

    摘要翻译： 提供了一种在高温下对纳米颗粒制剂进行灭菌的方法。 纯化多个纳米颗粒以形成制剂，其中所述纳米颗粒至少包含核和壳，并且所述壳包含连接到核的一种或多种配体物质。 纳米颗粒制备由纯化的纳米颗粒组合物，载体流体和过量的未连接到核的一种或多种配体物质制备。 在核心附着的配体物质和纯化后加入的过量配体物质在结构上是相同的。 本发明提供的纳米颗粒制剂可用作医学成像技术如X射线和磁共振成像中的造影剂。

    NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF
    10.
    发明申请
    NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF 有权
    纳米材料组合物及其相关方法

    公开(公告)号：US20120156141A1

    公开(公告)日：2012-06-21

    申请号：US12968577

    申请日：2010-12-15

    申请人： Bruce Allan Hay ,  Brian Christopher Bales ,  Michael Todd Luttrell ,  Binil Itty Ipe Kandapallil

    发明人： Bruce Allan Hay ,  Brian Christopher Bales ,  Michael Todd Luttrell ,  Binil Itty Ipe Kandapallil

    IPC分类号： A61K49/18 ,  A61P35/00 ,  B82Y30/00

    CPC分类号： A61K49/1842 ,  A61K49/1845 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

    摘要： A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.

    摘要翻译： 提供纳米颗粒组合物，其中所述组合物包含纳米颗粒金属氧化物; 和包含至少两个磷酸酯基团的磷酸化多元醇。 多元醇包含一个或多个选自聚乙烯醚部分，聚丙烯醚部分，聚丁烯醚部分以及前述亲水部分中两个或更多个的组合的亲水基团。 还提供了制备纳米颗粒组合物的方法。 本发明提供的纳米颗粒组合物可用作医学成像技术如X射线和磁共振成像中的造影剂。