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公开(公告)号：US20090074701A1
公开(公告)日：2009-03-19
申请号：US11855450
申请日：2007-09-14
Applicant: Delphine Allard , David W. Cannell , Michael S. DeGeorge , Jeremy Puco , Jonathan Wright
Inventor： Delphine Allard , David W. Cannell , Michael S. DeGeorge , Jeremy Puco , Jonathan Wright
CPC classification number: A61Q5/065 , A61K8/891 , A61K8/898 , A61K2800/594
Abstract: The invention relates to methods of artificially coloring hair including applying to hair a composition containing at least one silicone film forming resin, at least one polysilicone polymer, and at least one hair colorant.
Abstract translation: 本发明涉及人发毛发的方法，包括向毛发施用含有至少一种硅氧烷成膜树脂，至少一种聚硅氧烷聚合物和至少一种毛发着色剂的组合物。
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2.发明申请Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US20070060598A1
公开(公告)日：2007-03-15
申请号：US11411413
申请日：2006-04-26
Applicant: Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
Inventor： Ronald Albers , Leticia Ayala , Steven Clareen , Maria Delgado Mederos , Robert Hilgraf , Sayee Hegde , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy Palanki , Kiran Sahasrabudhe , John Sapienza , Yoshitaka Satoh , Marianne Sloss , Elise Sudbeck , Jonathan Wright
IPC: A61K31/52 , C07D473/14
CPC classification number: A61K31/52 , C07D473/32
Abstract: Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
Abstract translation: 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。
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3.发明授权1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents 失效1,3-取代的环烯烃和环烷烃作为中枢神经系统药剂
公开(公告)号：US5314896A
公开(公告)日：1994-05-24
申请号：US957277
申请日：1992-10-15
Applicant: Bradley W. Caprathe , Dennis M. Downing , Juan C. Jaen , Stephen J. Johnson , William J. Smith, III , Lawrence D. Wise , Jonathan Wright , David J. Wustrow
Inventor： Bradley W. Caprathe , Dennis M. Downing , Juan C. Jaen , Stephen J. Johnson , William J. Smith, III , Lawrence D. Wise , Jonathan Wright , David J. Wustrow
IPC: A61K31/36 , A61K31/357 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P43/00 , C07D20060101 , C07D211/70 , C07D211/82 , C07D213/38 , C07D213/74 , C07D239/26 , C07D239/42 , C07D295/02 , C07D295/03 , C07D295/04 , C07D317/58 , C07D401/08 , C07D405/08 , C07D409/04 , C07D409/08 , C07D417/08
CPC classification number: C07D213/74 , C07D211/70 , C07D295/03 , C07D401/08 , C07D405/08 , C07D409/04 , C07D409/08
Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
Abstract translation: 描述了1,3-取代的环烯烃和环烷烃，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药以及用于治疗高泌乳素血症 相关病症和中枢神经系统疾病。
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公开(公告)号：US20100233114A1
公开(公告)日：2010-09-16
申请号：US12699941
申请日：2010-02-04
Applicant: Michael S. DeGeorge , Jonathan Wright , Jeremy Puco
Inventor： Michael S. DeGeorge , Jonathan Wright , Jeremy Puco
Abstract: The invention relates to compositions containing at least one silicone film forming resin and at least one polysilicone polymer, as well as to methods of applying such compositions to keratin materials.
Abstract translation: 本发明涉及含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物，以及将这些组合物应用于角蛋白材料的方法。
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5.发明授权4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists 失效4-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途公开(公告)号：US06448270B1
公开(公告)日：2002-09-10
申请号：US09592883
申请日：2000-06-13
Applicant: Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F.W. Keana
Inventor： Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F.W. Keana
IPC: A61K31445
CPC classification number: C07D401/06 , C07D211/14 , C07D211/18 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/52 , C07D211/54 , C07D211/58 , C07D405/06
Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as cerebral ischemia, central nervous system trauma, hypoglycemia, neurodegenerative disorders, anxiety, migraine headaches, convulsions, aminoglycoside antibiotics-induced hearing loss, chronic pain, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, urinary incontinence and neurodegenerative disorders such as lathyrism, Alzheimers' Disease, Parkinsonism, and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.
Abstract translation: 新的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如脑缺血，中枢神经 系统性创伤，低血糖症，神经退行性疾病，焦虑症，偏头痛，惊厥，氨基糖苷类抗生素诱发的听力损失，慢性疼痛，精神病，青光眼，CMV视网膜炎，阿片样物质耐受或戒断，尿失禁和神经退行性疾病，如莱姆里斯，阿尔茨海默病， 描述了帕金森综合征和亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。
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Patent Agency Ranking6.发明授权4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists 失效4-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
公开(公告)号：US6130234A
公开(公告)日：2000-10-10
申请号：US91594
申请日：1996-12-20
Applicant: Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F. W. Keana
Inventor： Christopher F. Bigge , Jonathan Wright , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Zhang-Lin Zhou , John F. W. Keana
IPC: A61K31/00 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/4535 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/498 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P25/00 , A61P25/02 , A61P25/04 , A61P43/00 , C07D211/14 , C07D211/18 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/52 , C07D211/54 , C07D211/58 , C07D211/70 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D235/08
CPC classification number: C07D401/06 , C07D211/14 , C07D211/18 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/52 , C07D211/54 , C07D211/58 , C07D405/06
Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headaches, glaucoma, CMV retinitis, chronic pain, opioid tolerance or withdrawals, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.
Abstract translation: PCT No.PCT / US96 / 20766 Sec。 371日期：1998年9月16日 102（e）1998年9月16日PCT PCT 1996年12月20日PCT公布。 公开号WO97 / 23214 PCT 日期1997年7月3日新颖的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如中风 ，脑缺血，中枢神经系统创伤，低血糖症，焦虑症，抽搐，氨基糖苷类抗生素诱发的听力损失，偏头痛，青光眼，CMV视网膜炎，慢性疼痛，阿片样物质耐受或戒断，或神经退行性疾病，如幻影，阿尔茨海默病，帕金森综合征 并描述亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。
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公开(公告)号：US07601179B2
公开(公告)日：2009-10-13
申请号：US11855598
申请日：2007-09-14
Applicant: Delphine Allard , David W. Cannell , Michael S. DeGeorge , Jeremy Puco , Jonathan Wright
Inventor： Delphine Allard , David W. Cannell , Michael S. DeGeorge , Jeremy Puco , Jonathan Wright
IPC: A61Q5/10
CPC classification number: A61Q5/065 , A61K8/891 , A61K8/898 , A61K2800/594
Abstract: The invention relates to methods of preserving artificial color on keratin materials including applying to artificially colored keratin materials a composition containing at least one silicone film forming resin and at least one polysilicone polymer.
Abstract translation: 本发明涉及在角蛋白材料上保存人造色的方法，包括向人造着色的角蛋白材料施用含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物。
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8.发明授权Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith 有权卤代芳基取代的氨基嘌呤，其组合物及其处理方法公开(公告)号：US07521446B2
公开(公告)日：2009-04-21
申请号：US11411413
申请日：2006-04-26
Applicant: Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
Inventor： Ronald J. Albers , Leticia Ayala , Steven S. Clareen , Maria Mercedes Delgado Mederos , Robert Hilgraf , Kevin Hughes , Adam Kois , Veronique Plantevin-Krenitsky , Meg McCarrick , Lisa Nadolny , Moorthy S. S. Palanki , Kiran Sahasrabudhe , Yoshitaka Satoh , Marianne K. Sloss , Elise Sudbeck , Jonathan Wright
IPC: C07D473/32 , A61K31/52 , A61P3/10 , A61P11/00 , C07D239/50 , C07D239/48
CPC classification number: A61K31/52 , C07D473/32
Abstract: Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
Abstract translation: 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。
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公开(公告)号：US20090074702A1
公开(公告)日：2009-03-19
申请号：US11855598
申请日：2007-09-14
Applicant: Delphine Allard , David W. Cannell , Michael S. DeGeorge , Jeremy Puco , Jonathan Wright
Inventor： Delphine Allard , David W. Cannell , Michael S. DeGeorge , Jeremy Puco , Jonathan Wright
CPC classification number: A61Q5/065 , A61K8/891 , A61K8/898 , A61K2800/594
Abstract: The invention relates to methods of preserving artificial color on keratin materials including applying to artificially colored keratin materials a composition containing at least one silicone film forming resin and at least one polysilicone polymer.
Abstract translation: 本发明涉及在角蛋白材料上保存人造色的方法，包括向人造着色的角蛋白材料施用含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物。
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10.发明授权公开(公告)号：US07358274B2
公开(公告)日：2008-04-15
申请号：US11431056
申请日：2006-05-09
Applicant: Glenn Friedman , Jeffrey McKie , Jonathan Wright , Sophie Perrin-Ninkovic , Bernd M. Stein
Inventor： Glenn Friedman , Jeffrey McKie , Jonathan Wright , Sophie Perrin-Ninkovic , Bernd M. Stein
IPC: A61K31/4025 , C07D405/12
CPC classification number: C07D311/16 , A61K31/40
Abstract: This invention relates to Benzopyranone Compounds, compositions comprising a Benzopyranone Compound and methods for treating or preventing cancer or inhibiting the growth of a cancer cell or neoplastic cell comprising administering an effective amount of a Benzopyranone Compound. The Benzopyranone Compounds have the formula: or a pharmaceutically acceptable salt thereof, wherein R1 is halogen, trifluoromethyl or C1-6 alkyl.
Abstract translation: 本发明涉及苯并吡喃酮化合物，包含苯并吡喃酮化合物的组合物和用于治疗或预防癌症或抑制癌细胞或肿瘤细胞生长的方法，包括给予有效量的苯并吡喃酮化合物。 苯并吡喃酮化合物具有下式：或其药学上可接受的盐，其中R 1是卤素，三氟甲基或C 1-6烷基。
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