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公开(公告)号：US20130090479A1
公开(公告)日：2013-04-11
申请号：US13540651
申请日：2012-07-03
IPC分类号： C07D277/593 , C07D231/14
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
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2.发明申请THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES 失效作为蛋白激酶抑制剂的THIAZOLES，IMIDAZOLES和PYRAZOLES有用公开(公告)号：US20090306155A1
公开(公告)日：2009-12-10
申请号：US12538396
申请日：2009-08-10
IPC分类号： A61K31/426 , C07D231/14 , C07D277/56 , C12N5/00 , A61P37/00 , A61P29/00 , A61P19/00 , A61P3/00 , A61P25/00 , A61P35/00 , A61K31/415
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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3.发明授权公开(公告)号：US07589214B2
公开(公告)日：2009-09-15
申请号：US11786464
申请日：2007-04-11
IPC分类号： C07D233/64 , A61K31/4164
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含该化合物的药学上可接受的组合物，使用该化合物的方法和组合物治疗各种疾病，病症或病症。 本发明还涉及制备本发明化合物的方法。
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4.发明申请公开(公告)号：US20070298065A1
公开(公告)日：2007-12-27
申请号：US11786464
申请日：2007-04-11
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/426 , A61K9/00 , A61P43/00 , C07D231/02 , C07D233/54 , C07D277/02 , C12N9/99
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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5.发明授权公开(公告)号：US08865751B2
公开(公告)日：2014-10-21
申请号：US13540651
申请日：2012-07-03
IPC分类号： A61K31/415 , A61K31/426 , C07D231/12 , C07D277/24 , C07D277/593 , C07D233/64 , C07D233/90 , C07D277/56 , C07D231/14
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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6.发明授权公开(公告)号：US08236832B2
公开(公告)日：2012-08-07
申请号：US12538396
申请日：2009-08-10
IPC分类号： A61K31/415 , A61K31/426 , C07D277/24 , C07D231/12
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含该化合物的药学上可接受的组合物，使用该化合物的方法和组合物治疗各种疾病，病症或病症。 本发明还涉及制备本发明化合物的方法。
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公开(公告)号：US20120214799A1
公开(公告)日：2012-08-23
申请号：US13442244
申请日：2012-04-09
申请人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
发明人： Juan-Miguel Jimenez , Guy Bemis , Francois Maltais , Tiansheng Wang , Ronald Knegtel , Chris Davis , Damien Fraysse , Dean Boyall , Luca Settimo , Stephen Young , Michael Mortimore
IPC分类号： A61K31/551 , A61P25/28 , A61P25/14 , A61P25/16 , A61P25/00 , A61P25/18 , A61P7/00 , A61P9/00 , A61P9/10 , A61P29/00 , A61P1/00 , A61P35/00 , C07D401/06 , A61K31/444 , C07D401/14 , C07D417/14 , A61K31/496 , C07D409/06 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/497 , A61P3/10
CPC分类号： C07D213/73 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US20120136000A1
公开(公告)日：2012-05-31
申请号：US12670989
申请日：2010-01-27
申请人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
发明人： Juan-Miguel Jimenez , John Studley , Ronald Knegtel , Luca Settimo , Damien Fraysse , Philip N. Collier , Guy Brenchley , Dean Boyall , Andrew Miller , Heather Twin , Stephen Young
IPC分类号： A61K31/496 , A61K31/497 , A61K31/437 , A61K31/506 , A61P37/00 , A61P29/00 , A61P35/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P1/00 , A61P37/06 , A61P35/02 , A61P19/04 , C07D471/04
CPC分类号： C07D471/04 , A61K31/496 , A61K31/506 , C07D239/24 , C07D241/10 , C07D519/00
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
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公开(公告)号：US08017619B2
公开(公告)日：2011-09-13
申请号：US12713811
申请日：2010-02-26
申请人： Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人： Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号： A01N43/54 , A61K31/505 , C07D491/00
CPC分类号： A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法，包含该化合物的药学上可接受的组合物，以及使用该化合物和组合物治疗各种疾病，病症或病症的方法。
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10.发明授权公开(公告)号：US07855214B2
公开(公告)日：2010-12-21
申请号：US11046664
申请日：2005-01-26
申请人： Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
发明人： Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
IPC分类号： C07D487/22 , C07D487/14 , A61K31/519 , A61P35/00 , A61P29/00
CPC分类号： C07D403/12 , C07D471/04 , C07D487/04 , C07D487/12
摘要： The present invention relates to compounds useful as inhibitors of Tec family protein kinases. These compounds have the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, G, Cy1, and X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作Tec家族蛋白激酶抑制剂的化合物。 这些化合物具有通式I或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，G，Cy 1和X如本文所定义。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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