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1.发明申请SATURATED AND UNSATURATED SILAHYDROCARBONS VIA IRON AND COBALT PYRIDINE DIIMINE CATALYZED OLEFIN SILYLATION 有权饱和和不饱和硅烷通过铁和钴吡啶二胺催化烯烃硅酸盐公开(公告)号：US20140330036A1
公开(公告)日：2014-11-06
申请号：US14243044
申请日：2014-04-02
申请人： Kenrick Martin Lewis , Crisita Carmen Hojilla Atienza , Julie L. Boyer , Paul J. Chirik , Johannes G.P. Delis , Aroop Kumar Roy
发明人： Kenrick Martin Lewis , Crisita Carmen Hojilla Atienza , Julie L. Boyer , Paul J. Chirik , Johannes G.P. Delis , Aroop Kumar Roy
IPC分类号： C07F7/08
CPC分类号： C07F7/0829 , C07F7/0805 , C07F7/0896 , C07F15/02 , C07F15/025 , C07F15/06 , C07F15/065
摘要： The present invention relates to processes for the synthesis of saturated and unsaturated silahydrocarbons using iron-containing or cobalt-containing catalysts. The processes of the invention can produce tetraalkylsilanes, phenyltrialkylsilanes, substituted phenyltrialkylsilanes and their mixtures, which are useful as lubricants and hydraulic fluids, as well as alkyl alkenylsilanes, phenyl alkenylsilanes and substituted phenyl alkenylsilanes and their mixtures, which are useful in the synthesis of saturated silahydrocarbons and other organofunctional silanes.
摘要翻译： 本发明涉及使用含铁或含钴催化剂合成饱和和不饱和硅烷烃的方法。 本发明的方法可以生产四烷基硅烷，苯基三烷基硅烷，取代的苯基三烷基硅烷及其混合物，其可用作润滑剂和液压流体，以及烷基烯基硅烷，苯基烯基硅烷和取代的苯基烯基硅烷及其混合物，其可用于合成饱和 硅烷烃等有机官能硅烷。
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2.发明授权Activation of metal salts with silylhydrides and their use in hydrosilylation reactions 有权金属盐与甲硅烷基化的活化及其在氢化硅烷化反应中的应用公开(公告)号：US09440999B2
公开(公告)日：2016-09-13
申请号：US14278099
申请日：2014-05-15
申请人： Julie L. Boyer , Aroop Kumar Roy
发明人： Julie L. Boyer , Aroop Kumar Roy
CPC分类号： C07F7/1876 , B01J31/1815 , B01J31/2239 , B01J2231/323 , B01J2531/007 , B01J2531/72 , B01J2531/821 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07F7/0838 , C07F7/0879 , C07F7/0896 , C07F7/1804
摘要： The invention relates generally to transition metal salts, more specifically to iron, nickel, cobalt, manganese and ruthenium salts, activated with silylhydrides, and their use as efficient hydrosilylation catalysts.
摘要翻译： 本发明一般涉及过渡金属盐，更具体地涉及用甲硅烷基化氢活化的铁，镍，钴，锰和钌盐，以及它们作为有效的氢化硅烷化催化剂的用途。
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3.发明授权Saturated and unsaturated silahydrocarbons via iron and cobalt pyridine diimine catalyzed olefin silylation 有权饱和和不饱和硅烃通过铁和钴吡啶二亚胺催化烯烃甲硅烷基化公开(公告)号：US09371339B2
公开(公告)日：2016-06-21
申请号：US14243044
申请日：2014-04-02
申请人： Kenrick Martin Lewis , Crisita Carmen Hojilla Atienza , Julie L. Boyer , Paul J. Chirik , Johannes G. P. Delis , Aroop Kumar Roy
发明人： Kenrick Martin Lewis , Crisita Carmen Hojilla Atienza , Julie L. Boyer , Paul J. Chirik , Johannes G. P. Delis , Aroop Kumar Roy
CPC分类号： C07F7/0829 , C07F7/0805 , C07F7/0896 , C07F15/02 , C07F15/025 , C07F15/06 , C07F15/065
摘要： The present invention relates to processes for the synthesis of saturated and unsaturated silahydrocarbons using iron-containing or cobalt-containing catalysts. The processes of the invention can produce tetraalkylsilanes, phenyltrialkylsilanes, substituted phenyltrialkylsilanes and their mixtures, which are useful as lubricants and hydraulic fluids, as well as alkyl alkenylsilanes, phenyl alkenylsilanes and substituted phenyl alkenylsilanes and their mixtures, which are useful in the synthesis of saturated silahydrocarbons and other organofunctional silanes.
摘要翻译： 本发明涉及使用含铁或含钴催化剂合成饱和和不饱和硅烷烃的方法。 本发明的方法可以生产四烷基硅烷，苯基三烷基硅烷，取代的苯基三烷基硅烷及其混合物，其可用作润滑剂和液压流体，以及烷基烯基硅烷，苯基烯基硅烷和取代的苯基烯基硅烷及其混合物，其可用于合成饱和 硅烷烃等有机官能硅烷。
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4.发明授权Reusable homogeneous cobalt pyridine diimine catalysts for dehydrogenative silylation and tandem dehydrogenative-silylation-hydrogenation 有权用于脱氢甲硅烷基化和串联脱氢甲硅烷基化氢化的可重复使用的均匀的钴吡啶二亚胺催化剂公开(公告)号：US09447125B2
公开(公告)日：2016-09-20
申请号：US14270710
申请日：2014-05-06
申请人： Aroop Kumar Roy , Crisita Carmen Hojilla Atienza , Paul J. Chirik , Kenrick M. Lewis , Keith J. Weller , Susan Nye , Johannes G. P. Delis , Julie L. Boyer , Tianning Diao , Eric Pohl
发明人： Aroop Kumar Roy , Crisita Carmen Hojilla Atienza , Paul J. Chirik , Kenrick M. Lewis , Keith J. Weller , Susan Nye , Johannes G. P. Delis , Julie L. Boyer , Tianning Diao , Eric Pohl
IPC分类号： C08G77/06 , C07F7/18 , C07F7/08 , C08G77/38 , B01J31/18 , C07F15/06 , C08L83/04 , C08L83/14 , C08G77/04 , C08G77/12 , C08G77/20
CPC分类号： C07F7/1876 , B01J31/1815 , B01J2231/323 , B01J2531/0241 , B01J2531/0244 , B01J2531/845 , C07F7/0829 , C07F7/0838 , C07F7/0879 , C07F7/1804 , C07F15/065 , C08G77/12 , C08G77/20 , C08G77/38 , C08L83/04 , C08L83/14
摘要： Disclosed herein are cobalt complexes containing terdentate pyridine di-imine ligands and their use as efficient, reusable, and selective dehydrogenative silylation, crosslinking, and tandem dehydrogenative silylation-hydrogenation catalysts.
摘要翻译： 本文公开了含有三齿吡啶二亚胺配体的钴配合物及其作为有效，可重复使用和选择性脱氢甲硅烷基化，交联和串联脱氢甲硅烷基化氢化催化剂的用途。
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5.发明申请ACTIVATION OF METAL SALTS WITH SILYLHYDRIDES AND THEIR USE IN HYDROSILYLATION REACTIONS 有权金属盐与硅胶的活化及其在氢化反应中的应用公开(公告)号：US20140343311A1
公开(公告)日：2014-11-20
申请号：US14278099
申请日：2014-05-15
申请人： Julie L. Boyer , Aroop Kumar Roy
发明人： Julie L. Boyer , Aroop Kumar Roy
CPC分类号： C07F7/1876 , B01J31/1815 , B01J31/2239 , B01J2231/323 , B01J2531/007 , B01J2531/72 , B01J2531/821 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07F7/0838 , C07F7/0879 , C07F7/0896 , C07F7/1804
摘要： The invention relates generally to transition metal salts, more specifically to iron, nickel, cobalt, manganese and ruthenium salts, activated with silylhydrides, and their use as efficient hydrosilylation catalysts.
摘要翻译： 本发明一般涉及过渡金属盐，更具体地涉及用甲硅烷基化氢活化的铁，镍，钴，锰和钌盐，以及它们作为有效的氢化硅烷化催化剂的用途。
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6.发明申请REUSABLE HOMOGENEOUS COBALT PYRIDINE DIIMINE CATALYSTS FOR DEHYDROGENATIVE SILYLATION AND TANDEM DEHYDROGENATIVE-SILYLATION-HYDROGENATION 有权用于去离子硅烷化和均聚脱氢硅烷化加氢反应的均匀的均匀的钴盐酸二丁酯催化剂公开(公告)号：US20140243486A1
公开(公告)日：2014-08-28
申请号：US14270710
申请日：2014-05-06
申请人： Aroop Kumar Roy , Crisita Carmen Hojilla Atienza , Paul J. Chirik , Kenrick M. Lewis , Keith J. Weller , Susan Nye , Johannes G.P. Delis , Julie L. Boyer , Tianning Diao , Eric Pohl
发明人： Aroop Kumar Roy , Crisita Carmen Hojilla Atienza , Paul J. Chirik , Kenrick M. Lewis , Keith J. Weller , Susan Nye , Johannes G.P. Delis , Julie L. Boyer , Tianning Diao , Eric Pohl
CPC分类号： C07F7/1876 , B01J31/1815 , B01J2231/323 , B01J2531/0241 , B01J2531/0244 , B01J2531/845 , C07F7/0829 , C07F7/0838 , C07F7/0879 , C07F7/1804 , C07F15/065 , C08G77/12 , C08G77/20 , C08G77/38 , C08L83/04 , C08L83/14
摘要： Disclosed herein are cobalt complexes containing terdentate pyridine di-imine ligands and their use as efficient, reusable, and selective dehydrogenative silylation, crosslinking, and tandem dehydrogenative silylation-hydrogenation catalysts.
摘要翻译： 本文公开了含有三齿吡啶二亚胺配体的钴配合物及其作为有效，可重复使用和选择性脱氢甲硅烷基化，交联和串联脱氢甲硅烷基化氢化催化剂的用途。
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公开(公告)号：US20110086063A1
公开(公告)日：2011-04-14
申请号：US12995851
申请日：2009-06-04
IPC分类号： A61K39/235 , A61K31/7088 , A61P25/36 , A61P25/30 , A61P25/34 , C12N7/00 , C12N15/63
CPC分类号： A61K39/0013 , A61K47/643 , A61K47/646 , A61K2039/525 , A61K2039/55522 , A61K2039/55527 , A61K2039/6012 , A61K2039/6075 , A61P37/06 , C07K14/70575 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343
摘要： The invention provides an adenovirus-antigen conjugate comprising an adenovirus with a coat protein and an antigen of an addictive drug conjugated to the coat protein of the adenovirus. The invention also provides an adenoviral vector comprising a nucleic acid sequence which encodes an antibody directed against the addictive drug. The invention further provides a method of inducing an immune response against an addictive drug or reducing the effect of an addictive drug in a human by ad-ministering to the human the aforementioned adenovirus-antigen conjugate or antibody encoding adenoviral vector.
摘要翻译： 本发明提供一种腺病毒 - 抗原结合物，其包含具有外壳蛋白的腺病毒和与腺病毒的外壳蛋白缀合的成瘾药物的抗原。 本发明还提供了包含编码针对上瘾药物的抗体的核酸序列的腺病毒载体。 本发明进一步提供一种通过向人提供上述腺病毒 - 抗原缀合物或编码腺病毒载体的抗体，诱导针对成瘾药物的免疫应答或降低成瘾药物对人体的作用的方法。
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公开(公告)号：US07022496B2
公开(公告)日：2006-04-04
申请号：US09904698
申请日：2001-07-13
申请人： Gary Ketner , Julie L. Boyer
发明人： Gary Ketner , Julie L. Boyer
IPC分类号： C12P21/00
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2710/10322 , C12N2710/10343 , C12N2840/203 , C12N2840/44
摘要： The present invention provides a modified adenovirus comprising genomic adenoviral DNA which has been modified so that (i) the only gene product of the early region (E4) that is expressed is open reading frame 6 (ORF-6), (ii) neither the gene product of the E1A region nor the gene product of the E1B region is expressed, and (iii) no other early or late gene products are expressed. The present invention also provides methods of inhibiting repair of breaks in double-stranded DNA in a cell, preventing concatamerization of linear wild-type adenoviral DNA, inhibiting V(D)J recombination of nucleic acid sequences encoding immunoglobulins, preventing apoptosis, and preventing and treating cancer.
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9.发明申请COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST YERSINIA PESTIS 有权用于诱导对YERSINIA PESTIS产生免疫反应的组合物和方法公开(公告)号：US20090104232A1
公开(公告)日：2009-04-23
申请号：US12238129
申请日：2008-09-25
申请人： Ronald G. Crystal , Julie L. Boyer
发明人： Ronald G. Crystal , Julie L. Boyer
CPC分类号： C07K16/1228 , A61K39/025 , A61K2039/5256 , A61K2039/53 , C07K2317/56 , C12N2799/022 , C12N2799/04 , C12N2799/06 , Y02A50/407
摘要： The invention provides a gene transfer vector for inducing an immune response against Yersinia pestis in a mammal. The gene transfer vector comprises a nucleic acid sequence encoding an immunogenic portion of one or more proteins of Yersinia pestis and/or a nucleic acid sequence encoding a monoclonal antibody directed against Yersinia pestis. The invention further provides a method of producing an immune response against Yersinia pestis in a mammal comprising administration of the gene transfer vector to the mammal. The invention also provides a monoclonal antibody directed against the Virulence (V) antigen of Y. pestis, as well as a hybridoma cell line producing same and a nucleic acid sequence encoding same.
摘要翻译： 本发明提供了用于在哺乳动物中诱导针对鼠疫耶尔森氏菌的免疫应答的基因转移载体。 基因转移载体包含编码鼠疫耶尔森疫苗的一种或多种蛋白质的免疫原性部分的核酸序列和/或编码针对鼠疫耶尔森菌的单克隆抗体的核酸序列。 本发明进一步提供了在哺乳动物中产生针对鼠疫耶尔森疫霉的免疫应答的方法，包括向哺乳动物施用基因转移载体。 本发明还提供了针对鼠疫耶氏菌的毒力（V）抗原的单克隆抗体，以及产生其的杂交瘤细胞系和编码它的核酸序列。
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