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公开(公告)号：US07226911B2
公开(公告)日：2007-06-05
申请号：US10846374
申请日：2004-05-13
申请人： Jun Kudo , Kazunori Shibuya , Nobuyoshi Shimizu
发明人： Jun Kudo , Kazunori Shibuya , Nobuyoshi Shimizu
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4741
摘要： The present invention relates to provide a protein group binding to keratin which is the major component of body hair, or genes encoding the same, particularly to keratin-associated proteins (KAP) which bind specifically and strongly to hair keratin or genes encoding the same. The base sequence of eurochromtic region of approximately 33.5 Mb of human chromosome 21 was determined, a dot-matrix analysis of the base sequence of the long arm region of chromosome 21 (21q22.3) was carried out, homology search was made to low frequency repetitive sequences and 16 KAP genes being expressed only in hair root cells were found. Moreover, the high frequency repetitive sequences present in the sequence spanning for approximately 1 Mb between CLDN8 gene and TIAM1 gene in the long arm region of chromosome 21(21q22.11) were masked, the presence or absence of short low frequency repetitive sequence was searched, and 22 KAP genes were found. Moreover, a group of functional peptide was designed from the above mentioned KAPs.
摘要翻译： 本发明涉及提供与作为身体毛发的主要成分的角蛋白结合的蛋白质组，或编码其的基因，特别是与毛发角蛋白特异性强烈结合的角蛋白相关蛋白（KAP）或其编码基因的角蛋白相关蛋白（KAP）。 测定21号染色体约33.5Mb的欧洲色素碱基序列，对21号染色体长臂区（21q22.3）的碱基序列进行点阵分析，对低频进行同源性检索 发现重复序列和仅在发根细胞中表达的16个KAP基因。 此外，染色体21（21q22.11）的长臂区域中CLDN8基因和TIAM1基因之间跨越约1Mb的序列中存在的高频重复序列被掩蔽，搜索是否存在短的低频重复序列 ，发现22个KAP基因。 此外，从上述KAP设计了一组功能性肽。
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公开(公告)号：US20050170366A1
公开(公告)日：2005-08-04
申请号：US10846374
申请日：2004-05-13
申请人： Jun Kudo , Kazunori Shibuya , Nobuyoshi Shimizu
发明人： Jun Kudo , Kazunori Shibuya , Nobuyoshi Shimizu
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12Q1/68 , A01K67/027 , A61K7/06 , A61K7/11 , C07H21/04
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/4741
摘要： The present invention relates to provide a protein group binding to keratin which is the major component of body hair, or genes encoding the same, particularly to keratin-associated proteins (KAP) which bind specifically and strongly to hair keratin or genes encoding the same. The base sequence of eurochromtic region of approximately 33.5 Mb of human chromosome 21 was determined, a dot-matrix analysis of the base sequence of the long arm region of chromosome 21 (21q22.3) was carried out, homology search was made to low frequency repetitive sequences and 16 KAP genes being expressed only in hair root cells were found. Moreover, the high frequency repetitive sequences present in the sequence spanning for approximately 1 Mb between CLDN8 gene and TIAM1 gene in the long arm region of chromosome 21 (21q22.11) were masked, the presence or absence of short low frequency repetitive sequence was searched, and 22 KAP genes were found. Moreover, a group of functional peptide was designed from the above mentioned KAPs.
摘要翻译： 本发明涉及提供与作为身体毛发的主要成分的角蛋白结合的蛋白质组，或编码其的基因，特别是与毛发角蛋白特异性强烈结合的角蛋白相关蛋白（KAP）或其编码基因的角蛋白相关蛋白（KAP）。 测定21号染色体约33.5Mb的欧洲色素碱基序列，对21号染色体长臂区（21q22.3）的碱基序列进行点阵分析，对低频进行同源性检索 发现重复序列和仅在发根细胞中表达的16个KAP基因。 此外，染色体21（21q22.11）的长臂区域中CLDN8基因和TIAM1基因之间跨越约1Mb的序列中存在的高频重复序列被掩蔽，搜索是否存在短的低频重复序列 ，发现22个KAP基因。 此外，从上述KAP设计了一组功能性肽。
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3.发明授权Position detecting method for touchscreen panel, touchscreen panel, and electronic apparatus 有权触摸屏面板，触摸屏面板和电子设备的位置检测方法公开(公告)号：US09280249B2
公开(公告)日：2016-03-08
申请号：US12759791
申请日：2010-04-14
申请人： Koichi Kondoh , Takashi Nakajima , Nobuyoshi Shimizu , Masanobu Hayama , Norio Endo , Daisuke Ichikawa
发明人： Koichi Kondoh , Takashi Nakajima , Nobuyoshi Shimizu , Masanobu Hayama , Norio Endo , Daisuke Ichikawa
IPC分类号： G06F3/045 , G06F3/041 , G06F3/0488
CPC分类号： G06F3/045 , G06F3/0416 , G06F3/0488 , G06F2203/04104 , G06F2203/04808
摘要： A position detecting method for a touchscreen panel includes the steps of (a) determining the presence or absence of contact with the touchscreen panel on a conductive film divided into multiple conductive regions; (b) measuring a time after the detection of the absence of the contact and determining whether the measured time is less than a predetermined time if step (a) determines the absence of the contact; and (c) determining the continuance of the contact if the measured time is less than the predetermined time.
摘要翻译： 一种用于触摸屏面板的位置检测方法，包括以下步骤：（a）确定在分成多个导电区域的导电膜上是否存在触摸屏面板的接触; （b）测量在不存在接触之后的时间，并且如果步骤（a）确定不存在接触，则确定所测量的时间是否小于预定时间; 和（c）如果测量时间小于预定时间，则确定接触的连续性。
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公开(公告)号：US09029513B2
公开(公告)日：2015-05-12
申请号：US13701947
申请日：2011-06-03
IPC分类号： C07K16/30 , A61K39/395 , C07K16/28
CPC分类号： C07K16/30 , A61K39/39558 , C07K16/2863 , C07K2317/73
摘要： A cell growth inhibitor that includes, as an antibody component, an artificially produced anti-EGFR antibody having specific binding capacity to EGFR which is characterized in that an epitope therefor is in a cysteine-rich subdomain 2 (C2 domain) and/or in a ligand-binding domain 1 (L1 domain) among four subdomains contained in the extracellular domain of EGFR.
摘要翻译： 作为抗体成分的细胞生长抑制剂，其特征在于，其表位为富含半胱氨酸的亚结构域2（C2结构域）和/或 配体结合域1（L1结构域）在包含在EGFR细胞外结构域的四个子结构域之间。
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公开(公告)号：US08711089B2
公开(公告)日：2014-04-29
申请号：US11288370
申请日：2005-11-29
IPC分类号： G09G5/00
CPC分类号： G06F3/0354
摘要： A position detection device includes an electromagnetic conversion element and a magnetic field generator. The electromagnetic conversion element is arranged on a given plane. The magnetic field generator is arranged facing one side of the electromagnetic conversion element in a direction vertical to the given plane and generates a magnetic field covering the electromagnetic conversion element. A relative position between the electromagnetic conversion element and the magnetic field generator is detected when a relative displacement parallel to the given plane is made by the electromagnetic conversion element and the magnetic field generator based on an output signal of the electromagnetic conversion element. The magnetic field generator has an opposed face that tilts to the electromagnetic conversion element, and generates the magnetic field from the opposed face.
摘要翻译： 位置检测装置包括电磁转换元件和磁场发生器。 电磁转换元件设置在给定的平面上。 磁场发生器沿垂直于给定平面的方向布置成面对电磁转换元件的一侧，并产生覆盖电磁转换元件的磁场。 当电磁转换元件和磁场发生器基于电磁转换元件的输出信号进行平行于给定平面的相对位移时，检测电磁转换元件与磁场发生器之间的相对位置。 磁场发生器具有倾斜于电磁转换元件的相对面，并从相对面产生磁场。
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公开(公告)号：US08530163B2
公开(公告)日：2013-09-10
申请号：US12120040
申请日：2008-05-13
CPC分类号： C12Q1/6895
摘要： A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 4 and mutated sequences thereof.
摘要翻译： 提供探针，一组探针和探针或探针载体，探针或探针组固定在其上，用于分类真菌。 探针或一组探针能够共同检测相同物种的真菌，并将这些真菌与其他物种的真菌区分开来。 探针是用于检测病原真菌DNA的寡核苷酸探针，包括SEQ ID NOS的至少一个碱基序列。 1至4及其突变序列。
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公开(公告)号：US20130157898A1
公开(公告)日：2013-06-20
申请号：US13527332
申请日：2012-06-19
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6895 , C12Q1/689
摘要： A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 4 and mutated sequences thereof.
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公开(公告)号：US08178320B2
公开(公告)日：2012-05-15
申请号：US10496349
申请日：2002-11-22
CPC分类号： C40B40/02 , C07K16/00 , C07K16/005 , C07K2317/565 , C07K2317/622 , C12N15/1037 , C12N15/1093 , G01N2500/00
摘要： An artificial antibody library with a super-repertory (1011 or more) is constructed by: using a cDNA library as a template, amplifying a fragment containing the CDR1 and CDR2s regions of the VH or VL region of immunoglobulin gene and a fragment containing the CDR3 region each by the PCR method; integrating the VH library and the VL library, which are little contaminated with unexpressionable repertory and have high safety, into an non-expression vector; transferring it into a host; and then shuffling the VH region in the VH library with the VL region in the VL library.
摘要翻译： 通过使用cDNA文库作为模板，扩增含有免疫球蛋白基因的VH或VL区域的CDR1和CDR2区域的片段和含有CDR3的片段，构建具有超级片段（1011以上）的人工抗体文库 区域各自采用PCR法; 将不具有不可表达的毒素并且具有高度安全性的VH文库和VL文库整合到非表达载体中; 将其转移到主机中; 然后用VL库中的VL区域混合VH库中的VH区。
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公开(公告)号：US08153371B2
公开(公告)日：2012-04-10
申请号：US12948724
申请日：2010-11-17
CPC分类号： C12Q1/6895
摘要： A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus from fungus of other species. The probe is an oligonucleotide probe for detecting a pathogenic fungus DNA and includes at least one of base sequences of SEQ ID NOS. 1 to 4 and mutated sequences thereof.
摘要翻译： 提供探针，一组探针和探针或探针载体，探针或探针组固定在其上，用于分类真菌。 探针或一组探针能够共同检测相同物种的真菌，并将这些真菌与其他物种的真菌区分开来。 探针是用于检测病原真菌DNA的寡核苷酸探针，包括SEQ ID NOS的至少一个碱基序列。 1至4及其突变序列。
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公开(公告)号：US20110267044A1
公开(公告)日：2011-11-03
申请号：US13067070
申请日：2011-05-05
IPC分类号： G01B7/14
CPC分类号： G06F3/0354
摘要： A position detection device includes an electromagnetic conversion element and a magnetic field generator. The electromagnetic conversion element is arranged on a given plane. The magnetic field generator is arranged facing one side of the electromagnetic conversion element in a direction vertical to the given plane and generates a magnetic field covering the electromagnetic conversion element. A relative position between the electromagnetic conversion element and the magnetic field generator is detected when a relative displacement parallel to the given plane is made by the electromagnetic conversion element and the magnetic field generator based on an output signal of the electromagnetic conversion element. The magnetic field generator has an opposed face that tilts to the electromagnetic conversion element, and generates the magnetic field from the opposed face.
摘要翻译： 位置检测装置包括电磁转换元件和磁场发生器。 电磁转换元件设置在给定的平面上。 磁场发生器沿垂直于给定平面的方向布置成面对电磁转换元件的一侧，并产生覆盖电磁转换元件的磁场。 当电磁转换元件和磁场发生器基于电磁转换元件的输出信号进行平行于给定平面的相对位移时，检测电磁转换元件与磁场发生器之间的相对位置。 磁场发生器具有倾斜于电磁转换元件的相对面，并从相对面产生磁场。
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