公开(公告)号：US08023109B2

公开(公告)日：2011-09-20

申请号：US12895776

申请日：2010-09-30

申请人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

发明人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

IPC分类号： G01N21/27 ,  G01N21/64

CPC分类号： G01N21/05 ,  G01N21/554 ,  G01N21/645 ,  G01N21/66 ,  G01N2021/0346

摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。

公开(公告)号：US20110019195A1

公开(公告)日：2011-01-27

申请号：US12895776

申请日：2010-09-30

申请人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

发明人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

IPC分类号： G01N21/59

CPC分类号： G01N21/05 ,  G01N21/554 ,  G01N21/645 ,  G01N21/66 ,  G01N2021/0346

摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。

公开(公告)号：US20090009756A1

公开(公告)日：2009-01-08

申请号：US10571906

申请日：2005-03-02

申请人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

发明人： Junta Yamamichi ,  Miki Ogawa ,  Yoichiro Handa ,  Takeshi Imamura ,  Norihiko Utsunomiya ,  Satoru Nishiuma

IPC分类号： G01N21/01

CPC分类号： G01N21/05 ,  G01N21/554 ,  G01N21/645 ,  G01N21/66 ,  G01N2021/0346

摘要： A detection device comprising a substrate comprising a plurality of objects of which properties are changed due to the contact with a target substance, means for bringing the target substance into contact with the objects, and means for detecting a change in properties of the objects caused when the target substance is brought into contact with the objects, based on light output when the objects are irradiated with light, wherein the plurality of the objects are located in the direction in which the light for irradiation travels, and the detecting means is means for detecting the change in the properties based on the summation of light output from the plurality of the objects upon irradiation with light.

摘要翻译： 一种检测装置，包括：基板，包括由于与目标物质的接触而使特性变化的多个物体;使目标物质与物体接触的装置;以及用于检测物体的特性变化的装置， 当物体被光照射时，目标物质与物体接触，其中多个物体位于照射光的行进方向上，检测装置是检测装置 基于在照射光时来自多个物体的光输出的总和的属性的变化。

公开(公告)号：US07465579B2

公开(公告)日：2008-12-16

申请号：US11165524

申请日：2005-06-24

申请人： Satoru Hatakeyama ,  Hideaki Okamoto ,  Norihiko Utsunomiya ,  Junta Yamamichi

发明人： Satoru Hatakeyama ,  Hideaki Okamoto ,  Norihiko Utsunomiya ,  Junta Yamamichi

IPC分类号： C12M1/00 ,  C12M3/00

CPC分类号： C12N13/00 ,  C12M35/02

摘要： A device for introducing fine magnetic particles into a cell by applying an electric field to a reaction field where a sample solution containing cells and the fine magnetic particles are introduced, in order to form pores in the surface of the cell, and then applying a magnetic field to the reaction field to introduce the fine magnetic particles into the cell through the pore(s).

摘要翻译： 通过向导入含有电池和微细粒子的样品溶液的反应场施加电场，将细磁粒子引入电池的装置，以在电池表面形成孔，然后施加磁 通过反应场将微细磁性颗粒引入细胞中。

公开(公告)号：US08283183B2

公开(公告)日：2012-10-09

申请号：US11114077

申请日：2005-04-26

申请人： Takashi Ikeda ,  Norihiko Utsunomiya ,  Junta Yamamichi

发明人： Takashi Ikeda ,  Norihiko Utsunomiya ,  Junta Yamamichi

IPC分类号： G01N33/533 ,  H01G4/16

CPC分类号： G01N15/1031 ,  G01N33/54326

摘要： A detection device and a detecting method using the detection device are provided in which a magnetic particle is used as a marker particle, and the ratio of a region with reversed magnetization to the whole area of a free layer of a magnetoresistive effect film is increased by a stray magnetic field generated through a biochemical reaction from the magnetic particle remaining on a surface of the magnetoresistive effect film, so that a large detection signal is obtained and obtained detection data can be stored with stability.

摘要翻译： 提供一种检测装置和使用该检测装置的检测方法，其中使用磁性颗粒作为标记颗粒，并且具有反磁化的区域与磁阻效应膜的自由层的整个区域的比例增加 通过从残留在磁阻效应膜的表面上的磁性颗粒的生化反应产生的杂散磁场，从而可以稳定地存储获得大的检测信号并获得检测数据。

公开(公告)号：US20050244873A1

公开(公告)日：2005-11-03

申请号：US11114077

申请日：2005-04-26

申请人： Takashi Ikeda ,  Norihiko Utsunomiya ,  Junta Yamamichi

发明人： Takashi Ikeda ,  Norihiko Utsunomiya ,  Junta Yamamichi

IPC分类号： G01R33/09 ,  C12Q1/68 ,  G01N15/10 ,  G01N27/72 ,  G01N27/74 ,  G01N33/543 ,  G01N33/551 ,  G01N33/553 ,  G01R33/12

CPC分类号： G01N15/1031 ,  G01N33/54326

摘要： A detection device and a detecting method using the detection device are provided in which a magnetic particle is used as a marker particle and a ratio of a region with reversed magnetization to the whole area of a free layer of a magnetoresistive effect film is increased by a stray magnetic field generated through a biochemical reaction from the magnetic particle remaining on a surface of the magnetoresistive effect film, so that a large detection signal is obtained and obtained detection data can be stored with stability.

摘要翻译： 提供一种使用该检测装置的检测装置和检测方法，其中使用磁性颗粒作为标记颗粒，并且具有反磁化的区域与磁阻效应膜的自由层的整个区域的比例增加了 通过从残留在磁阻效应膜的表面上的磁性颗粒的生化反应产生的杂散磁场，从而获得大的检测信号，并且可以稳定地存储所获得的检测数据。

公开(公告)号：US08198100B2

公开(公告)日：2012-06-12

申请号：US11114077

申请日：2005-04-26

申请人： Takashi Ikeda ,  Norihiko Utsunomiya ,  Junta Yamamichi

发明人： Takashi Ikeda ,  Norihiko Utsunomiya ,  Junta Yamamichi

IPC分类号： G01N33/533 ,  H01G4/16

摘要： A detection device and a detecting method using the detection device are provided in which a magnetic particle is used as a marker particle, and the ratio of a region with reversed magnetization to the whole area of a free layer of a magnetoresistive effect film is increased by a stray magnetic field generated through a biochemical reaction from the magnetic particle remaining on a surface of the magnetoresistive effect film, so that a large detection signal is obtained and obtained detection data can be stored with stability.

公开(公告)号：US20070004019A1

公开(公告)日：2007-01-04

申请号：US11165524

申请日：2005-06-24

申请人： Satoru Hatakeyama ,  Hideaki Okamoto ,  Norihiko Utsunomiya ,  Junta Yamamichi

发明人： Satoru Hatakeyama ,  Hideaki Okamoto ,  Norihiko Utsunomiya ,  Junta Yamamichi

IPC分类号： C12N13/00

CPC分类号： C12N13/00 ,  C12M35/02

摘要： A device for introducing fine magnetic particles into a cell by applying an electric field to a reaction field where a sample solution containing cells and the fine magnetic particles are introduced, in order to form pores in the surface of the cell, and then applying a magnetic field to the reaction field to introduce the fine magnetic particles into the cell through the pore(s).

摘要翻译： 通过向导入含有电池和微细粒子的样品溶液的反应场施加电场，将细磁粒子引入电池的装置，以在电池表面形成孔，然后施加磁 通过反应场将微细磁性颗粒引入细胞中。

公开(公告)号：US07659987B2

公开(公告)日：2010-02-09

申请号：US11659717

申请日：2005-09-14

申请人： Norihiko Utsunomiya ,  Mitsuro Sugita ,  Satoru Nishiuma ,  Takao Yonehara

发明人： Norihiko Utsunomiya ,  Mitsuro Sugita ,  Satoru Nishiuma ,  Takao Yonehara

IPC分类号： G01N21/00

CPC分类号： G01N21/554 ,  G01N21/648 ,  G01N2021/258 ,  G01N2201/0635 ,  G01N2201/0636

摘要： An information-acquiring device for acquiring information on an objective substance to be detected, which is provided with a sensing element that has a surface capable of fixing the objective substance to be detected thereon, and makes applied light change its wavelength characteristics in response to the fixed state of the objective substance to be detected onto the surface, a light source, and light-receiving means for receiving light emitted from the light source through the sensing element, has the light-receiving means and the light source arranged on the same substrate so that the light which has been emitted from the light source and has been transmitted through the sensing element can be led to the light-receiving means, and has means for varying the wavelength regions of each light incident on each of a plurality of the light-receiving means installed in an optical path from the light source to the light-receiving means.

摘要翻译： 一种信息获取装置，用于获取关于待检测的物质的信息，该信息获取装置设置有具有能够固定待检测的物体的表面的感测元件，并且使得施加的光响应于该检测元件的波长特性而改变其 要检测的目标物质的固定状态，光源和用于接收通过感测元件从光源发射的光的光接收装置，其中光接收装置和光源布置在同一基板上 使得已经从光源发射并已经透射通过感测元件的光可以被引导到光接收装置，并且具有用于改变入射到多个光中的每一个的每个光的波长区域的装置 - 接收装置安装在从光源到光接收装置的光路中。

公开(公告)号：US20080225292A1

公开(公告)日：2008-09-18

申请号：US12123167

申请日：2008-05-19

申请人： Satoru Nishiuma ,  Norihiko Utsunomiya ,  Takashi Ikeda

发明人： Satoru Nishiuma ,  Norihiko Utsunomiya ,  Takashi Ikeda

IPC分类号： G01N21/00 ,  B01J19/08

CPC分类号： G01N33/54326 ,  G01N33/54373 ,  Y10S435/808 ,  Y10S436/805

摘要： Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a liquid medium. Subsequently, the dispersion of the magnetic particles is applied to a surface having a periodic structure that is adapted to generate plasmon resonance and a change in the plasmon resonance attributable to the concentration of the target substance held on the magnetic particles fixed magnetically to the surface is optically detected to determine the concentration of the target substance in the specimen.

摘要翻译： 使具有保持目标物质俘获物的金属涂层的磁性颗粒与磁性颗粒分散在液体介质中的溶液中的样品中包含的目标物质反应。 随后，将磁性颗粒的分散体施加到具有适于产生等离子体共振的周期性结构的表面，并且由于保持在磁性颗粒上的目标物质的浓度与表面固定的等离子体共振的变化是 光学检测以确定样品中目标物质的浓度。