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公开(公告)号：US08309562B2
公开(公告)日：2012-11-13
申请号：US12500863
申请日：2009-07-10
申请人： Mark B. Anderson , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
发明人： Mark B. Anderson , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof that are effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US20100069383A1
公开(公告)日：2010-03-18
申请号：US12500863
申请日：2009-07-10
申请人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
发明人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/52 , C07D413/12 , C07D473/00 , C07D401/12 , C07D239/95
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof that are effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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3.发明申请PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF 审中-公开作为细胞增殖抑制剂的药物化合物及其用途公开(公告)号：US20100068197A1
公开(公告)日：2010-03-18
申请号：US12500449
申请日：2009-07-09
申请人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Kazuyuki Suzuki , Robert J. Halter , In Chul Kim , Matthew Reeder , Ashantai Yungai
发明人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Kazuyuki Suzuki , Robert J. Halter , In Chul Kim , Matthew Reeder , Ashantai Yungai
IPC分类号： A61K31/517 , C07D239/95 , C07D403/12 , C07D487/04 , A61K31/5025 , A61P35/00 , A61K39/395 , C12N5/00
CPC分类号： C07D403/12 , C07D239/95 , C07D487/04
摘要： Disclosed are compounds of Formula I effective as cytotoxic agents. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为细胞毒性剂有效的式I化合物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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4.发明申请PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF 审中-公开作为细胞增殖抑制剂的药物化合物及其用途公开(公告)号：US20090280133A1
公开(公告)日：2009-11-12
申请号：US12465786
申请日：2009-05-14
IPC分类号： A61K39/395 , C07D239/42 , A61K31/505 , A61P35/00
CPC分类号： C07D239/42 , C07D239/48 , C07D239/69
摘要： Disclosed are compounds of Formula I effective as cytotoxic agents. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为细胞毒性剂有效的式I化合物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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5.发明申请COMPOSITIONS AND THERAPEUTIC USES OF IKK-RELATED KINASE EPSILON AND TANKBINDING KINASE 1 INHIBITORS 审中-公开IKK相关激素EPSILON和TANKINDING KINASE 1抑制剂的组合物和治疗用途公开(公告)号：US20140288044A1
公开(公告)日：2014-09-25
申请号：US14112847
申请日：2012-04-12
申请人： Ryan Holcomb , Paul R. Sebahar , Kazuyuki Suzuki , Donald A. McLeod , David M. Dastrup , Christophe Hoarau , Robert J. Halter , Matthew Gregory Bursavich , Mark D. Shenderovich , Burt Richards , Paul L. Bartel
发明人： Ryan Holcomb , Paul R. Sebahar , Kazuyuki Suzuki , Donald A. McLeod , David M. Dastrup , Christophe Hoarau , Robert J. Halter , Matthew Gregory Bursavich , Mark D. Shenderovich , Burt Richards , Paul L. Bartel
IPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D405/14 , C07D409/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention relates to compounds, pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders.
摘要翻译： 本发明涉及包含这些化合物的化合物，药物组合物和药物，以及这些化合物，组合物和药物在治疗疾病和病症的方法中的用途。
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6.发明申请AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 审中-公开作为IKK EPSILON和/或TBK1的抑制剂的氨基吡啶化合物公开(公告)号：US20120238540A1
公开(公告)日：2012-09-20
申请号：US13445627
申请日：2012-04-12
申请人： Ryan C. HOLCOMB , Kazuyuki Suzuki , Robert J. Halter , Paul R. Sebahar , Donald A. McLeod , Mark D. Shenderovich , Kraig M. Yager , Matthew Gregory Bursavich , Ashantai J. Yungai , Burt Richards , Paul L. Bartel , Daniel A. Wettstein
发明人： Ryan C. HOLCOMB , Kazuyuki Suzuki , Robert J. Halter , Paul R. Sebahar , Donald A. McLeod , Mark D. Shenderovich , Kraig M. Yager , Matthew Gregory Bursavich , Ashantai J. Yungai , Burt Richards , Paul L. Bartel , Daniel A. Wettstein
IPC分类号： A61K31/506 , A61K31/5377 , C07D405/12 , C07D413/14 , C07D403/12 , A61K31/551 , A61P29/00 , A61P19/04 , A61P17/06 , A61P11/00 , A61P1/00 , A61P3/04 , A61P5/48 , A61P3/00 , A61P35/00 , C12N5/071 , C07D413/12
CPC分类号： A61K31/505 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/635 , C07D239/42 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08
摘要： The invention relates to certain amino-pyrimidine compounds that inhibit IKK epsilon and/or TBK1, methods of making such compounds, pharmaceutical compositions comprising such compounds, and the use of these compounds in treating a variety of diseases and disorders.
摘要翻译： 本发明涉及抑制IKKε和/或TBK1的某些氨基嘧啶化合物，制备这些化合物的方法，包含这些化合物的药物组合物以及这些化合物在治疗各种疾病和病症中的用途。
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7.发明授权4-arylamin-or-4-heteroarylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效4-芳基氨基 - 或 - 4-杂芳基氨基 - 喹唑啉及其类似物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途公开(公告)号：US07989462B2
公开(公告)日：2011-08-02
申请号：US11773303
申请日：2007-07-03
申请人： Sui Xiong Cai , Mark B. Anderson , Adam Willardsen , Nilantha Sudath Sirisoma , Hong Zhang , Kazuyuki Suzuki
发明人： Sui Xiong Cai , Mark B. Anderson , Adam Willardsen , Nilantha Sudath Sirisoma , Hong Zhang , Kazuyuki Suzuki
IPC分类号： A01N43/90 , A61K31/519 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D239/02
CPC分类号： C07D239/94 , C07D239/72 , C07D403/12
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US20100107996A1
公开(公告)日：2010-05-06
申请号：US12595285
申请日：2008-05-19
CPC分类号： E02F9/2025 , F01P7/044 , F01P7/08 , F02D29/02 , F02D29/04
摘要： A work vehicle is provided with an engine, a traveling device driven by driving force from the engine to cause the work vehicle to travel, a first hydraulic pump driven by the driving force from the engine to discharge hydraulic oil, and a cooling device having a cooling fan driven by the hydraulic oil supplied by the first hydraulic pump to cool the engine, and a control unit. The control unit performs a normal cooling control in which an upper limit fan speed is determined based on an engine speed, and a cooling suppression control in which the upper limit fan speed determined based on the engine speed is suppressed to be less than the upper limit fan speed during the normal cooling control when a predetermined operation required to increase the engine speed is performed.
摘要翻译： 工作车辆设置有发动机，由发动机的驱动力驱动以使作业车辆行驶的行驶装置，由来自发动机的驱动力驱动以排出液压油的第一液压泵，以及具有 由第一液压泵供应的液压油驱动的冷却风扇以冷却发动机，以及控制单元。 控制单元进行基于发动机转速确定上限风扇速度的正常冷却控制，将根据发动机转速确定的上限风扇速度抑制在小于上限的冷却抑制控制 执行提高发动机转速所需的规定动作时的正常冷却控制时的风扇转速。
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公开(公告)号：US20080004297A1
公开(公告)日：2008-01-03
申请号：US11773303
申请日：2007-07-03
申请人： Sui Cai , Mark Anderson , Adam Willardsen , Nilantha Sirisoma , Hong Zhang , Kazuyuki Suzuki
发明人： Sui Cai , Mark Anderson , Adam Willardsen , Nilantha Sirisoma , Hong Zhang , Kazuyuki Suzuki
IPC分类号： A61K31/517 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/00 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12
CPC分类号： C07D239/94 , C07D239/72 , C07D403/12
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US20050205272A1
公开(公告)日：2005-09-22
申请号：US11000405
申请日：2004-12-01
申请人： Kazuyuki Suzuki , Takeshi Takaura
发明人： Kazuyuki Suzuki , Takeshi Takaura
CPC分类号： E02F9/2228 , E02F3/844 , E02F9/2235 , E02F9/2285
摘要： A hydraulic control apparatus which is used in order to prevent the blade from falling over on the pitch back side during a dual tilting operation, and to operate the left and right tilting cylinders in a uniform manner even in case where there is a large difference in the load pressure between the left and right tilting cylinders. In cases where it is desired to perform a dual tilting operation, the operator moves the operating lever either leftward or rightward while pressing the dual tilting switch of the operating lever. As a result of the switch being pressed, an electrical control signal that places the flow-combining/flow-dividing switching valve or flow-combining/flow-dividing valve in the flow-dividing position is generated by the controller, and the electrical control signal is output to the flow-combining/flow-dividing switching valve so that the flow-combining/flow-dividing switching valve or flow-combining/flow-dividing valve is switched to the flow-dividing position.
摘要翻译： 一种液压控制装置，其用于在双重倾斜操作期间防止叶片在后倾侧上落下，并且即使在差异较大的情况下也以均匀的方式操作左右倾斜滚筒 左右倾斜缸之间的负载压力。 在需要执行双倾斜操作的情况下，操作者在按压操作杆的双倾斜开关的同时向左或向右移动操作杆。 作为开关被按压的结果，通过控制器产生将流量合流/分流切换阀或流动组合/分流阀放置在分流位置的电气控制信号，并且电气控制 信号被输出到流动组合/分流切换阀，使得流动组合/分流切换阀或流动组合/分流阀切换到分流位置。
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