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公开(公告)号：US20100069383A1
公开(公告)日：2010-03-18
申请号：US12500863
申请日：2009-07-10
申请人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
发明人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/52 , C07D413/12 , C07D473/00 , C07D401/12 , C07D239/95
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof that are effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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2.发明申请PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF 审中-公开作为细胞增殖抑制剂的药物化合物及其用途公开(公告)号：US20100068197A1
公开(公告)日：2010-03-18
申请号：US12500449
申请日：2009-07-09
申请人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Kazuyuki Suzuki , Robert J. Halter , In Chul Kim , Matthew Reeder , Ashantai Yungai
发明人： MARK B. ANDERSON , J. Adam Willardsen , Warren S. Weiner , Kazuyuki Suzuki , Robert J. Halter , In Chul Kim , Matthew Reeder , Ashantai Yungai
IPC分类号： A61K31/517 , C07D239/95 , C07D403/12 , C07D487/04 , A61K31/5025 , A61P35/00 , A61K39/395 , C12N5/00
CPC分类号： C07D403/12 , C07D239/95 , C07D487/04
摘要： Disclosed are compounds of Formula I effective as cytotoxic agents. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为细胞毒性剂有效的式I化合物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US20150353538A1
公开(公告)日：2015-12-10
申请号：US14589939
申请日：2015-01-05
申请人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David D. Dastrup
发明人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David D. Dastrup
IPC分类号： C07D471/04 , C07D213/61 , C07D213/65 , C07D401/12 , C07D235/06 , C07D213/71 , C07D409/12 , C07D213/75 , C07D413/12 , C07D213/64 , C07D213/73 , C07D333/22 , C07D417/12 , C07D213/68 , C07D233/64 , C07D307/48 , C07D237/20 , C07D213/53
CPC分类号： C07D213/75 , C07B2200/05 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/47 , C07D209/14 , C07D213/42 , C07D213/53 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/73 , C07D215/46 , C07D231/12 , C07D231/40 , C07D233/64 , C07D235/06 , C07D237/20 , C07D261/08 , C07D307/14 , C07D307/48 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/22 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.
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公开(公告)号：US08309562B2
公开(公告)日：2012-11-13
申请号：US12500863
申请日：2009-07-10
申请人： Mark B. Anderson , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
发明人： Mark B. Anderson , J. Adam Willardsen , Warren S. Weiner , Ashantai Yungai , Robert J. Halter , Yevgeniya Klimova , Kazuyuki Suzuki , Matthew Reeder
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72
CPC分类号： C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D487/04
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof that are effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US20150344426A1
公开(公告)日：2015-12-03
申请号：US14582641
申请日：2014-12-24
IPC分类号： C07D213/58 , C07D401/12 , C07D403/12
CPC分类号： C07D213/58 , C07D213/40 , C07D401/12 , C07D403/12 , C07D405/06
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.
摘要翻译： 本发明涉及可用于治疗癌症，全身或慢性炎症，类风湿性关节炎，糖尿病，肥胖症，T细胞介导的自身免疫疾病，缺血以及与这些疾病和病症相关的其它并发症的化合物，药物组合物和方法。
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公开(公告)号：US20120122840A1
公开(公告)日：2012-05-17
申请号：US13243876
申请日：2011-09-23
申请人： Dange Vijay Kumar , Ian A. McAlexander , Matthew Gregory Bursavich , Christophe Hoarau , Paul M. Slattum , David A. Gerrish , Jeffrey W. Lockman , Weston R. Judd , Michael Saunders , Daniel P. Parker , Daniel Feodore Zigar , In Chul Kim , J. Adam Willardsen , Kraig M. Yager , Mark D. Shenderovich , Brandi L. Williams , Keith D. Tardif
发明人： Dange Vijay Kumar , Ian A. McAlexander , Matthew Gregory Bursavich , Christophe Hoarau , Paul M. Slattum , David A. Gerrish , Jeffrey W. Lockman , Weston R. Judd , Michael Saunders , Daniel P. Parker , Daniel Feodore Zigar , In Chul Kim , J. Adam Willardsen , Kraig M. Yager , Mark D. Shenderovich , Brandi L. Williams , Keith D. Tardif
IPC分类号： A61K31/541 , C07D473/32 , G01N33/567 , A61K31/5377 , A61P35/00 , C07D473/16 , A61K31/52
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention relates to compounds, pharmaceutical compositions, and uses thereof, including therapeutic uses thereof, such as methods useful for treating cancer.
摘要翻译： 本发明涉及化合物，药物组合物及其用途，包括其治疗用途，例如可用于治疗癌症的方法。
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公开(公告)号：US20120329786A1
公开(公告)日：2012-12-27
申请号：US13601879
申请日：2012-08-31
申请人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David M. Dastrup
发明人： J. Adam Willardsen , Jeffrey W. Lockman , Brett R. Murphy , Weston R. Judd , In Chul Kim , Se-Ho Kim , Daniel Feodore Zigar , Kraig M. Yager , Tracey C. Fleischer , Ryan T. Terry-Lorenzo , J. Jay Boniface , Daniel P. Parker , Ian A. McAlexander , Matthew Gregory Bursavich , David M. Dastrup
IPC分类号： A61K31/549 , C12N5/02 , A61K31/5377 , A61K31/50 , A61K31/519 , A61K31/47 , A61K31/4545 , A61K31/4406 , A61K31/4402 , A61K31/357 , A61K31/17 , C07D417/12 , C07D413/12 , C07D237/20 , C07D471/04 , C07D215/46 , C07D401/12 , C07D211/98 , C07D211/04 , C07D317/46 , C07C275/40 , A61P35/00 , A61P29/00 , A61P19/02 , A61P3/04 , A61P3/10 , A61P9/10 , C12Q1/02
CPC分类号： C07D213/75 , C07B2200/05 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/47 , C07D209/14 , C07D213/42 , C07D213/53 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/73 , C07D215/46 , C07D231/12 , C07D231/40 , C07D233/64 , C07D235/06 , C07D237/20 , C07D261/08 , C07D307/14 , C07D307/48 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/22 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.
摘要翻译： 本发明涉及可用于治疗癌症，全身或慢性炎症，类风湿性关节炎，糖尿病，肥胖症，T细胞介导的自身免疫疾病，缺血以及与这些疾病和病症相关的其它并发症的化合物，药物组合物和方法。
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