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公开(公告)号：US20240053364A1
公开(公告)日：2024-02-15
申请号：US18126546
申请日：2023-03-27
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N2800/347 , G01N2800/52 , G01N2333/70578 , G01N2333/4706 , G01N2333/4727 , G01N2333/70596 , G01N2333/8146
Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US20230279290A1
公开(公告)日：2023-09-07
申请号：US18145735
申请日：2022-12-22
Applicant: Meso Scale Technologies, LLC.
Inventor： John Kenten , John Pettersson , George Sigal , Alexander K. Tucker-Schwartz
IPC: C09K11/02 , C12Q1/6816
CPC classification number: C09K11/02 , C12Q1/6816
Abstract: The disclosure relates to novel compositions comprising an electrochemiluminescence (ECL) co-reactant. In embodiments, the composition further comprises an ionic component, a surfactant, or combination thereof. In embodiments, the ECL co-reactant is triethanolamine (TEA), tert-butyldiethanolamine (tBDEA), methyldibutylethanolamine (MDEA), 3-[Bis-(2-hydroxy-ethyl)-amino]-propane-1-sulfonic acid (DEA-PS), or a combination thereof. Methods of using the compositions and kits comprising the compositions are also provided herein, including methods using ECL-labeled oligonucleotide probes having quenching moieties.
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公开(公告)号：US10408823B2
公开(公告)日：2019-09-10
申请号：US15311309
申请日：2015-05-15
Applicant: MESO SCALE TECHNOLOGIES, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , George Sigal , Martin Stengelin , David Routenberg
IPC: C12Q1/6832 , C12Q1/6837 , G01N33/543 , C12Q1/6844
Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.
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公开(公告)号：US20140221325A1
公开(公告)日：2014-08-07
申请号：US14168688
申请日：2014-01-30
Applicant: Meso Scale Technologies, LLC
Inventor： Eli N. Glezer , John Kenten , Galina Nikolenko
CPC classification number: G01N33/6893 , G01N2800/347 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
Abstract translation: 本发明涉及诊断患者的肾小球肾炎（GN）的方法以及监测GN进展的方法和/或监测治疗剂或治疗方案的治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。
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公开(公告)号：US11697840B2
公开(公告)日：2023-07-11
申请号：US16136498
申请日：2018-09-20
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , John Kenten
IPC: C12Q1/6844 , G01N33/543 , C12Q1/682 , C12Q1/6837 , C12Q1/6848 , C12Q1/6804 , G01N33/542
CPC classification number: C12Q1/6844 , C12Q1/682 , C12Q1/6804 , C12Q1/6837 , C12Q1/6848 , G01N33/542 , G01N33/54306 , C12Q2531/125 , C12Q2533/107 , G01N2458/10 , C12Q1/6848 , C12Q2531/125 , C12Q2565/549 , C12Q1/6804 , C12Q2531/125 , C12Q2533/107 , C12Q2565/401 , C12Q2565/519
Abstract: The present invention is directed to improved methods for conducting immunoassays. The methods are designed to amplify signals in immunoassays and anchor immunoassay complexes employed therein.
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Patent Agency Ranking
公开(公告)号：US20190391140A1
公开(公告)日：2019-12-26
申请号：US16564208
申请日：2019-09-09
Applicant: MESO SCALE TECHNOLOGIES, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , George Sigal , Martin Stengelin , David Routenberg
IPC: G01N33/543 , C12Q1/6844 , C12Q1/6837 , C12Q1/6832
Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.
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公开(公告)号：US10436784B2
公开(公告)日：2019-10-08
申请号：US14854514
申请日：2015-09-15
Applicant: Meso Scale Technologies, LLC , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Inventor： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC: G01N33/53 , G01N33/569 , G01N33/68 , G01N33/566
Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20180246100A1
公开(公告)日：2018-08-30
申请号：US15902597
申请日：2018-02-22
Applicant: Meso Scale Technologies, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventor： William F. Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC: G01N33/569 , G01N33/566 , G01N33/68
CPC classification number: G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US20180074061A1
公开(公告)日：2018-03-15
申请号：US15813418
申请日：2017-11-15
Applicant: Meso Scale Technologies, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko , Martin Stengelin , Srikant Vaithilingam
IPC: G01N33/574
CPC classification number: G01N33/57423 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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公开(公告)号：US20170168047A1
公开(公告)日：2017-06-15
申请号：US15440191
申请日：2017-02-23
Applicant: Meso Scale Technologies, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , George Sigal , Martin Stengelin
CPC classification number: G01N33/54393 , C12Q1/6804 , G01N21/66 , G01N21/76 , G01N21/77 , G01N33/5306 , G01N33/5308 , G01N33/533 , G01N33/54306 , G01N33/56988 , G01N33/582 , G01N2021/7786 , C12Q2537/125 , C12Q2563/179
Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.
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