Method for the purification of liponic acid

    公开(公告)号:US20060014823A1

    公开(公告)日:2006-01-19

    申请号:US10532205

    申请日:2003-11-17

    IPC分类号: C07D339/02 A61K31/385

    CPC分类号: C07D339/04

    摘要: The invention relates to a process for purifying lipoic acid, which comprises adding to a solution of lipoic acid at least 0.1 times the amount of an adsorbent, based on the mass of lipoic acid to be purified, and subsequently removing the adsorbent. It is possible in this way to provide racemic or nonracemic lipoic acid with an oligomer content below 1% by weight, for example from 0.1 to 1% by weight.

    Thermoplastic polyamides having polyether amines
    4.
    发明授权
    Thermoplastic polyamides having polyether amines 有权
    具有聚醚胺的热塑性聚酰胺

    公开(公告)号:US08481652B2

    公开(公告)日:2013-07-09

    申请号:US12809478

    申请日:2008-12-15

    IPC分类号: C08L77/00

    摘要: Thermoplastic molding compositions comprising A) from 10 to 99% by weight of at least one thermoplastic polyamide, B) from 0.01 to 30% by weight of at least one highly branched or hyperbranched polyetheramine, C) from 0 to 70% by weight of further added materials, where the total of the percentages by weight of components A) to C) is 100%; the use of polyetheramines for improving the flowability and/or thermal stability of polyamides; and to the use of the molding compositions for the production of fibers, of foils, or of moldings of any type, and also to the resultant fibers, foils, or moldings.

    摘要翻译: 热塑性模塑组合物,其包含A)10至99重量%的至少一种热塑性聚酰胺,B)0.01至30重量%的至少一种高度支化或超支化的聚醚胺,C)0-70重量% 组分A)至C)的重量百分比的总和为100%; 使用聚醚胺改善聚酰胺的流动性和/或热稳定性; 以及用于生产纤维,箔或任何类型的模制品的成型组合物的用途,以及所得纤维,箔或模制品的使用。

    Stable ammonium salts of alpha-liponic acid, the production thereof and the use of the same
    5.
    发明申请
    Stable ammonium salts of alpha-liponic acid, the production thereof and the use of the same 审中-公开
    稳定的α-脂肪酸铵盐,其生产和使用

    公开(公告)号:US20060199847A1

    公开(公告)日:2006-09-07

    申请号:US10552964

    申请日:2004-04-14

    摘要: The invention relates to ammonium salts of α-liponic acid of general formula (I): (Lp) (A), formed from α-liponic acid (Lp) and amino compounds (A)=of general formula (II) or general formula (III). The invention also relates to a method for producing said salts, and to the use of said salts as constituents in pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements. The invention also relates to pharmaceutical, dermatological and cosmetic agents, foodstuffs, animal feed supplements or food supplements in which the inventive salts are used.

    摘要翻译: 本发明涉及由α-脂肪酸(Lp)和氨基化合物(A)=通式(II)或通式(II)形成的通式(I):(Lp)(A)的α-脂肪酸铵盐 (三)。 本发明还涉及制备所述盐的方法,以及所述盐作为药物,皮肤病学和美容剂,食品,动物饲料添加剂或食品补充剂中的成分的用途。 本发明还涉及其中使用本发明的盐的药物,皮肤病学和美容剂,食品,动物饲料补充剂或食品补充剂。

    Process for the preparation of lipoic acid and dihydrolipoic acid
    6.
    发明申请
    Process for the preparation of lipoic acid and dihydrolipoic acid 失效
    制备硫辛酸和二氢硫辛酸的方法

    公开(公告)号:US20050101669A1

    公开(公告)日:2005-05-12

    申请号:US10432455

    申请日:2001-11-29

    IPC分类号: C07D339/04 A61K31/20

    CPC分类号: C07D339/04

    摘要: The present invention relates to a process for the preparation of R— and S-lipoic acid and R— and S-dihydrolipoic acid comprising (a) reaction of where MS is SO2—R′ and R and R′ independently of one another are C1-C6-alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl, with sodium sulfide and sulfur in methanol. The invention especially relates to processes for preparing pure R— or S-dihydrolipoic acid, which is either used directly or processed further to give R— and S-lipoic acid. The process also serves for the production of pharmaceuticals. The present invention further relates to a solution of sodium sulfide trihydrate and sulfur in methanol, the sulfur being present in a molar excess over the sodium sulfide trihydrate, and a kit which comprises the solution according to the invention.

    摘要翻译: 本发明涉及制备R-和S-硫辛酸和R-和S-二氢硫辛酸的方法,其包括(a)其中MS为SO 2 -R'和R和 R'彼此独立地是C 1 -C 6 - 烷基,C 3 -C 8 - 环烷基 C 3 -C 8 - 环烷基烷基,芳基或芳烷基,与硫化钠和硫在甲醇中反应。 本发明特别涉及制备纯R-或S-二氢硫辛酸的方法,其可直接使用或进一步加工得到R-和S-硫辛酸。 该方法还用于生产药物。 本发明还涉及硫化钠三水合物和硫在甲醇中的溶液,所述硫以超过硫化钠三水合物的摩尔量存在,以及包含根据本发明的溶液的试剂盒。

    Flame-proofed polyester molding materials
    7.
    发明授权
    Flame-proofed polyester molding materials 失效
    防火聚酯成型组合物

    公开(公告)号:US06716899B1

    公开(公告)日:2004-04-06

    申请号:US09674540

    申请日:2000-11-02

    IPC分类号: C08K55377

    摘要: Thermoplastic molding compositions comprise A) from 5 to 96% by weight of a polyester, B) from 1 to 30% by weight of a phosphinate of formula I and/or of a diphosphinate of formula II and/or polymers of these  where: R1 and R2 are linear or branched C1-C6-alkyl, phenyl or hydrogen, R3 is linear or branched C1-C10-alkylene, arylene, alkylarylene or arylalkylene, M is an alkaline-earth or alkali metal, Zn, Al, Fe or B, m is an integer from 1 to 3, n is an integer from 1 to 3, is 1 or 2 and C) from 1 to 30% by weight of at least one organic phosphorus-containing flame retardant, D) from 0 to 5% by weight of at least one ester or amide of saturated or unsaturated aliphatic carboxylic acids having from 10 to 40 carbon atoms with saturated aliphatic alcohols or amines having from 2 to 40 carbon atoms, and E) from 0 to 60% by weight of other additives, where the total of the percentages by weight of components A) to E) is 100%.

    摘要翻译: 热塑性成型组合物包含A)5至96重量%的聚酯,B)1至30重量%的式I的次膦酸酯和/或式II的二膦酸盐和/或其它的聚合物:R 1 并且R 2是直链或支链C 1 -C 6 - 烷基,苯基或氢,R 3是直链或支链C 1 -C 10 - 亚烷基,亚芳基,烷基亚芳基或芳基亚烷基,M是碱土金属或碱金属, Zn,Al,Fe或B,m为1〜3的整数,n为1〜3的整数,为1或2,C为1〜30重量%的至少一种含有机磷的阻燃剂, D)0至5重量%的至少一种具有10至40个碳原子的饱和或不饱和脂族羧酸的酯或酰胺与饱和脂族醇或具有2至40个碳原子的胺,以及E)0至60 重量%的其他添加剂,其中组分A)至E)的重量百分比的总和为100%。

    Method for the continuous production of polybutylene terephthalate from terephthal acid and butane diole
    8.
    发明授权
    Method for the continuous production of polybutylene terephthalate from terephthal acid and butane diole 失效
    从对苯二酸和丁二烯连续生产聚对苯二甲酸丁二醇酯的方法

    公开(公告)号:US06657040B1

    公开(公告)日:2003-12-02

    申请号:US10018337

    申请日:2001-12-19

    IPC分类号: C08G6378

    CPC分类号: C08G63/78 C08G63/85

    摘要: The invention relates to a method for the continuous production of polybutylene terephthalate from terephthal acid and 1,4-butane diole, comprising the following stages: a) direct esterification of terephthal acid with 1,4-butane diole in a reactor cascade of at least two reactors b) pre-condensation of the esterification product obtained in stage a), c) polycondensation of the pre-condensate obtained in stage b), whereby the temperature of the reactor cascade in stage a) is progressively decreased during its operation.

    摘要翻译: 本发明涉及一种从对苯二酸和1,4-丁二烯连续生产聚对苯二甲酸丁二醇酯的方法,包括以下步骤:a)至少在反应器级联中直接酯化对苯二甲酸与1,4-丁烷二烯 两个反应器b)在步骤a)中获得的酯化产物的预缩合,c)在步骤b)中获得的预冷凝物的缩聚,由此在步骤a)中级联的反应器的温度在其操作期间逐渐降低。

    Flame-proof moulding compounds
    10.
    发明授权
    Flame-proof moulding compounds 失效
    防火成型料

    公开(公告)号:US06538054B1

    公开(公告)日:2003-03-25

    申请号:US09284414

    申请日:1999-04-14

    IPC分类号: C08K53492

    摘要: Thermoplastic molding compositions comprise A) from 30 to 96% by weight of a polyester B) from 1 to 30% by weight of melamine cyanurate C) from 1 to 30% by weight of at least one phosphorus-containing flame retardant D) from 0.01 to 5% by weight of at least one ester or amide derived from a saturated or unsaturated aliphatic carboxylic acid having from 10 to 40 carbon atoms and a saturated aliphatic alcohol or &mine having from 2 to 40 carbon atoms E) from 0 to 60% by weight of other additives and processing aids where the total of the percentages by weight of components A) to E) is 100%.

    摘要翻译: 热塑性模塑组合物包含A)30至96重量%的聚酯B)1至30重量%的三聚氰胺氰尿酸酯C)1至30重量%的至少一种含磷阻燃剂D)0.01至5重量% 至少一种衍生自具有10至40个碳原子的饱和或不饱和脂族羧酸的酯或酰胺的重量和具有2至40个碳原子的饱和脂族醇或矿物E)0至60重量%的其它添加剂,以及 加工助剂,其中组分A)至E)的重量百分比的总和为100%。