公开(公告)号：US20220369961A1

公开(公告)日：2022-11-24

申请号：US17663657

申请日：2022-05-16

Applicant: Medtronic, Inc.

Inventor： Kamal Deep Mothilal ,  Michael D. Eggen ,  Ning Yu ,  John P. Keane ,  Shantanu Sarkar ,  Randal C. Schulhauser ,  David L. Probst ,  Mark R. Boone ,  Kenneth A. Timmerman ,  Stanley J. Taraszewski ,  Matthew A. Joyce ,  Amruta Paritosh Dixit ,  Kathryn E. Hilpisch ,  Kathryn Ann Milbrandt ,  Laura M. Zimmerman ,  Matthew L. Plante

IPC: A61B5/145 ,  A61B5/0205 ,  A61B5/00 ,  G16H50/20 ,  G16H50/30

Abstract: This disclosure is directed to systems and techniques for detecting change in patient health based upon patient data. In one example, a medical system comprising processing circuitry communicably coupled to a glucose sensor and configured to generate continuous glucose sensor measurements of a patient. The processing circuitry is further configured to: extract at least one feature from the continuous glucose sensor measurements over at least one time period, wherein the at least one feature comprises one or more of an amount of time within a pre-determined glucose level range, a number of hypoglycemia events, a number of hyperglycemia events, or one or more statistical metrics corresponding to the continuous glucose sensor measurements; apply a machine learning model to the at least one extracted feature to produce data indicative of a risk of a cardiovascular event; and generate output data based on the risk of the cardiovascular event.

公开(公告)号：US20240268721A1

公开(公告)日：2024-08-15

申请号：US18626074

申请日：2024-04-03

Applicant: Medtronic, Inc.

Inventor： Daniel Hahn ,  Akhil Srinivasan ,  Patrick W. Kinzie ,  Randal C. Schulhauser ,  Jennifer L. Marckmann ,  Mohsen Askarinya ,  James K. Carney ,  David L. Probst ,  Santhisagar Vaddiraju ,  Alejo Chavez Gaxiola ,  Richard J. O'Brien ,  Anna M. Tycon ,  Omid Mahdavi ,  Shawn C. Kelley ,  David A. Anderson

IPC: A61B5/1468 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1486 ,  G01N27/30 ,  G01N27/327

CPC classification number: A61B5/1468 ,  A61B5/053 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  G01N27/301 ,  G01N27/3271

Abstract: Techniques are disclosed for measuring an analyte in a biological system. A system may include a medical device with an electrochemical sensor configured to sense the concentration of a plurality of analytes present in a biological system. Processing circuitry of the system may retrieve, identify, and process a respective signal from a respective work electrode to determine the concentration of a respective analyte. The system may further include an implantable medical device configured to sense a cardiac electrogram (EGM). In some examples, the system may be configured to determine one or more patient-specific relationships between the respective signals of the electrochemical sensor and the cardiac EGM during a first period of time. Based on the patient-specific relationships, the system may estimate concentrations of the one or more analytes corresponding to the respective signals based on the cardiac EGM of the patient collected over a second period of time.

公开(公告)号：US12186076B2

公开(公告)日：2025-01-07

申请号：US17171474

申请日：2021-02-09

Applicant: Medtronic, Inc.

Inventor： David L. Probst ,  Mark R. Boone

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1486 ,  A61K49/00 ,  A61B5/00

Abstract: An example medical device includes an optical sensor, processing circuitry, an antenna, and a power source. The optical sensor includes a light source; a reference optical beacon having a first fluorophore that emits a first fluorescence proportional to a first concentration of a substance proximate the beacon; a test optical beacon having a reagent substrate that reacts with an analyte to produce the substance and a second fluorophore that emits a second fluorescence proportional to a second concentration of the substance proximate the test beacon; and a photodetector to detect the first and second fluorescence. The processing circuitry determines a difference between the first and second fluorescence, which is indicative of the concentration of the analyte. The antenna and power source enable the medical device to operate completely within a biological system for continuous analyte monitoring.

公开(公告)号：US20220248986A1

公开(公告)日：2022-08-11

申请号：US17171474

申请日：2021-02-09

Applicant: Medtronic, Inc.

Inventor： David L. Probst ,  Mark R. Boone

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1459 ,  A61K49/00

Abstract: An example medical device includes an optical sensor, processing circuitry, an antenna, and a power source. The optical sensor includes a light source; a reference optical beacon having a first fluorophore that emits a first fluorescence proportional to a first concentration of a substance proximate the beacon; a test optical beacon having a reagent substrate that reacts with an analyte to produce the substance and a second fluorophore that emits a second fluorescence proportional to a second concentration of the substance proximate the test beacon; and a photodetector to detect the first and second fluorescence. The processing circuitry determines a difference between the first and second fluorescence, which is indicative of the concentration of the analyte. The antenna and power source enable the medical device to operate completely within a biological system for continuous analyte monitoring.

公开(公告)号：US20220026386A1

公开(公告)日：2022-01-27

申请号：US17382151

申请日：2021-07-21

Applicant: Medtronic, Inc.

Inventor： Jennifer Lorenz Marckmann ,  Mohsen Askarinya ,  David L. Probst ,  John E. Burnes

IPC: G01N27/327 ,  G01N27/30 ,  G01N27/31

Abstract: An electrochemical sensor may include a common reference electrode, at least one counter electrode, and a work electrode platform including a work electrode and at least one diffusion control layer. The work electrode may be electrically coupled to the common reference electrode. The electrode may include a reagent substrate configured to react with an analyte to produce a signal indicative of a concentration of the analyte. The at least one diffusion control layer may be configured to control the diffusion of the analyte to the work electrode.