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公开(公告)号：US20200240903A1
公开(公告)日：2020-07-30
申请号：US16845560
申请日：2020-04-10
发明人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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2.发明授权公开(公告)号：US09804173B2
公开(公告)日：2017-10-31
申请号：US14478221
申请日：2014-09-05
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/70578 , G01N2800/065 , G01N2800/52
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
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3.发明申请公开(公告)号：US20160245799A1
公开(公告)日：2016-08-25
申请号：US15146293
申请日：2016-05-04
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
IPC分类号： G01N33/53 , G01N33/573 , G01N33/68 , G01N33/569
CPC分类号： G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
摘要翻译： 使用具有多个测定域的测定模块进行多重测试测量。 在优选实施方案中，这些测量在具有集成电极的测定模块中进行，所述测量模块具有适于接收测定模块的读取器装置，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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公开(公告)号：US20210033523A1
公开(公告)日：2021-02-04
申请号：US16996418
申请日：2020-08-18
发明人： Jacob N. Wohlstadter , Eli Glezer , James Wilbur , George Sigal , Kent Johnson , Charles Clinton , Alan Kishbaugh , Bandele Jeffrey-Coker , Jeff D. Debad , Alan B. Fischer
摘要： Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adopted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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公开(公告)号：US20200309790A1
公开(公告)日：2020-10-01
申请号：US16901294
申请日：2020-06-15
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： G01N33/68
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
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公开(公告)号：US20230038393A1
公开(公告)日：2023-02-09
申请号：US17720956
申请日：2022-04-14
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： G01N33/68
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient’s treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
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公开(公告)号：US20190257823A1
公开(公告)日：2019-08-22
申请号：US16401513
申请日：2019-05-02
发明人： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
IPC分类号： G01N33/53 , G01N33/68 , G01N33/573 , G01N33/569 , C12Q1/48 , G01N33/543
摘要： Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
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公开(公告)号：US09921166B2
公开(公告)日：2018-03-20
申请号：US14478197
申请日：2014-09-05
发明人： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeff D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
IPC分类号： G01N21/76 , B01L3/00 , B01L9/00 , C12Q1/00 , G01N33/543 , G01N27/30 , B01J19/00 , B33Y80/00 , C40B40/10
CPC分类号： G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
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公开(公告)号：US20140378347A1
公开(公告)日：2014-12-25
申请号：US14478221
申请日：2014-09-05
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/70578 , G01N2800/065 , G01N2800/52
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
摘要翻译： 公开了用于进行诸如克罗恩病和溃疡性结肠炎的炎症性肠病的检测的诊断测试的方法。 还描述了通过管理本发明的测试来监测患者的方法。 还描述了通过管理本发明的测试来监测患者治疗的方法。 还描述了通过将本发明的试验施用于用药物或候选药物治疗的患者，动物模型和细胞培养物的样品来评价药物或药物候选物的有效性的方法。 还公开了用于确定分析物的有用性的方法，例如， 用作本发明各种方法中用于炎性肠病的诊断和监测标志物的细胞因子。
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公开(公告)号：US10712351B2
公开(公告)日：2020-07-14
申请号：US15716743
申请日：2017-09-27
发明人： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC分类号： G01N33/68
摘要： Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
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