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公开(公告)号：US20190225644A1
公开(公告)日：2019-07-25
申请号：US15768193
申请日：2016-10-17
Applicant: ModernaTX, Inc.
Inventor： Gabor BUTORA , Matthew STANTON , Thomas STEELE
IPC: C07H19/207
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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公开(公告)号：US20180305393A1
公开(公告)日：2018-10-25
申请号：US16008662
申请日：2018-06-14
Applicant: ModernaTX, Inc.
Inventor： Gabor BUTORA , Matthew STANTON , Thomas STEELE
IPC: C07H21/02
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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公开(公告)号：US20240189242A1
公开(公告)日：2024-06-13
申请号：US18277346
申请日：2022-02-18
Applicant: MODERNATX, INC.
Inventor： Meredith PACKER , Dipendra GYAWALI , Serenus HUA , Gabor BUTORA , Gregory John MERCER
IPC: A61K9/51 , A61K31/7105 , A61K47/18 , A61K47/26
CPC classification number: A61K9/5123 , A61K31/7105 , A61K47/18 , A61K47/26
Abstract: Provided herein are methods of reducing adduct formation in lipid nanoparticle compositions comprising a polynucleotide, such as mRNA, and an ionizable lipid; also disclosed are lipid nanoparticle compositions having a reduced adduct content, and methods of detecting the adducts.
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公开(公告)号：US20190218546A1
公开(公告)日：2019-07-18
申请号：US15768199
申请日：2016-10-17
Applicant: ModernaTX, Inc.
Inventor： Gabor BUTORA , Matthew STANTON , Thomas STEELE
IPC: C12N15/10 , C07H21/02 , C07D473/18 , C07D473/34
CPC classification number: C12N15/1089 , C07D473/18 , C07D473/34 , C07H21/00 , C07H21/02 , C12N2310/3125 , C12N2310/313 , C12N2310/314 , C12N2310/317
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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公开(公告)号：US20230323344A1
公开(公告)日：2023-10-12
申请号：US17929956
申请日：2022-09-06
Applicant: ModernaTx, Inc.
Inventor： Gabor BUTORA , Andrew W. Fraley , Edward John Miracco , Jennifer Nelson , Amy Rhoden Smith , Matthew Stanton
IPC: C12N15/113 , C12N15/11
CPC classification number: C12N15/113 , C12N15/111 , C12N2310/317 , C12N2310/321 , C12N2310/3231 , C12N2310/3233 , C12N2310/351 , C12N2320/51
Abstract: The disclosure provides polynucleotides encoding a polypeptide including a morpholino linker. In some embodiments, the polynucleotides of the invention have increased stability compared to wild-type polynucleotides.
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Patent Agency Ranking
公开(公告)号：US20210347810A1
公开(公告)日：2021-11-11
申请号：US17278095
申请日：2019-09-19
Applicant: ModernaTX, Inc.
Inventor： Gabor BUTORA , Jin LIM , Gary SHEN , Alison VOLKERT
IPC: C07J9/00 , A61K9/51 , C07J17/00 , C07J31/00 , C07J33/00 , C07J41/00 , C07J43/00 , A61K31/575 , A61K45/06
Abstract: The invention relates to sterol esters and methods for producing purified sterols that can be utilized in methods for producing a lipid nanoparticle.
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公开(公告)号：US20180312535A1
公开(公告)日：2018-11-01
申请号：US16008655
申请日：2018-06-14
Applicant: ModernaTX, Inc.
Inventor： Gabor BUTORA , Matthew STANTON , Thomas STEELE
IPC: C07H21/02
CPC classification number: C12N15/1089 , C07D473/18 , C07D473/34 , C07H21/00 , C07H21/02 , C12N2310/3125 , C12N2310/313 , C12N2310/314 , C12N2310/317
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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公开(公告)号：US20190255194A1
公开(公告)日：2019-08-22
申请号：US16289947
申请日：2019-03-01
Applicant: ModernaTX, Inc.
Inventor： Atanu ROY , Christopher R. CONLEE , Antonin DE FOUGEROLLES , Andrew W. FRALEY , Gabor BUTORA , Matthew STANTON
IPC: A61K48/00 , C12N15/87 , C07D498/22 , C07H19/06 , C12N15/11 , C07D487/16 , C07D487/04 , C07D473/40 , C07D473/38 , C07D473/34 , C07D473/30 , C07D473/18 , C07D473/16 , C07H19/23 , C07H19/20 , C07H19/167 , C07H19/14 , C07H19/10 , C07H19/067 , C07D239/54 , C07D405/04 , C07F9/6561 , C07F9/6558 , C07H19/16 , C12N15/67 , C07H21/02
Abstract: The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.
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公开(公告)号：US20190211368A1
公开(公告)日：2019-07-11
申请号：US15768206
申请日：2016-10-17
Applicant: ModernaTX, Inc.
Inventor： Gabor BUTORA , Matthew STANTON , Edward John MIRACCO
IPC: C12P19/34 , C12N15/113 , C07H21/02 , C12N15/10 , C12N9/12 , A61K31/7125
CPC classification number: C12P19/34 , A61K31/7125 , C07H21/02 , C12N9/1247 , C12N15/1096 , C12N15/113 , C12N2310/317 , C12Y207/07006
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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公开(公告)号：US20180291055A1
公开(公告)日：2018-10-11
申请号：US16008658
申请日：2018-06-14
Applicant: ModernaTX, Inc.
Inventor： Gabor BUTORA , Matthew STANTON , Thomas STEELE
IPC: C07H21/02
Abstract: The present disclosure relates to cap analogs, which can result in high levels of capping efficiency and transcription and improved translation efficiencies. The present disclosure also relates to methods useful for preparing cap analogs and using mRNA species containing such analogs, as well as kits containing the novel cap analogs.
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