公开(公告)号：US07108787B2

公开(公告)日：2006-09-19

申请号：US10343014

申请日：2001-07-27

申请人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Shinji Miyazaki ,  Kazuo Imamura ,  Ken Suzuki ,  Koji Kamenosono

发明人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Shinji Miyazaki ,  Kazuo Imamura ,  Ken Suzuki ,  Koji Kamenosono

IPC分类号： B01D69/08 ,  B01D63/02 ,  B01D63/06

CPC分类号： B01D67/0088 ,  B01D67/0013 ,  B01D67/0016 ,  B01D69/02 ,  B01D69/08 ,  B01D71/28 ,  B01D71/40 ,  B01D71/76 ,  B01D2323/12

摘要： A modified hollow-fiber membrane which has improved surface hydrophilicity without increasing the amount of components released therefrom, is less apt to interact with living-body components, does not adsorb proteins, and is less apt to deteriorate in performance. The hollow-fiber membrane has a copolymer of 2-methacryloyloxyethylphosphorylcholine and other polymerizable vinyl monomer held on a surface of the membrane, the copolymer being present on the surface in a higher concentration than in other parts of the membrane. The modified hollow-fiber membrane is useful in medical applications such as hemodialysis and blood filtration and in the medical industry, food industry etc.

摘要翻译： 在不增加从其释放的成分的量的情况下具有改善的表面亲水性的改性中空纤维膜不容易与活体成分相互作用，不吸附蛋白质，并且性能较不易劣化。 中空纤维膜具有2-甲基丙烯酰氧基乙基磷酰胆碱和保持在膜表面上的其它可聚合乙烯基单体的共聚物，该共聚物以比膜的其它部分更高的浓度存在于表面上。 改性中空纤维膜可用于血液透析和血液过滤以及医疗行业，食品工业等医疗应用。

公开(公告)号：US06828028B1

公开(公告)日：2004-12-07

申请号：US10048367

申请日：2002-01-25

申请人： Hiroki Fukui ,  Ken Suzuki ,  Kenshiro Shuto ,  Nobuyuki Yamamoto ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

发明人： Hiroki Fukui ,  Ken Suzuki ,  Kenshiro Shuto ,  Nobuyuki Yamamoto ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

IPC分类号： B32B2738

CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06 ,  Y10T428/31511 ,  Y10T428/31515

摘要： A medical material having a surface which is safe and excellent in stability with the lapse of time and has a high durability as needed in establishing a long-lasting surface lubricity in a wet state and an excellent compatibility with blood, and a method for producing the same. These materials are obtained by forming a coating layer with a coating material containing a polymeric substance (A) having a heterocyclic group represented by the formula (1) on at least a part of a surface of a medical material base, and then ring-opening the heterocyclic group remaining in the coating layer by a nucleophilic compound (N): wherein X represents O, NH or S; and R1 represents H or CH3.

摘要翻译： 一种医用材料，其具有安全性和稳定性优异的时间，并且在建立湿状态下的持久的表面润滑性和与血液的优异的相容性方面需要时具有高的耐久性，以及用于制备 相同。 这些材料通过在包含医药材料基材的表面的至少一部分上的含有式（1）表示的具有杂环基的聚合物质（A）的涂布材料形成涂层而得到，然后开环 通过亲核化合物（N）保留在涂层中的杂环基：其中X表示O，NH或S; 且R 1表示H或CH 3。

公开(公告)号：US06706260B1

公开(公告)日：2004-03-16

申请号：US09743357

申请日：2001-01-05

申请人： Shinji Tanaka ,  Ken Suzuki ,  Kenshiro Shuto ,  Akio Hayashi ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

发明人： Shinji Tanaka ,  Ken Suzuki ,  Kenshiro Shuto ,  Akio Hayashi ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

IPC分类号： A61K3174

CPC分类号： C08F230/02 ,  A61L15/24 ,  A61L15/26 ,  A61L27/16 ,  C08F30/02 ,  C08L43/02 ,  C08F2220/1825 ,  C08F2222/108 ,  C08F2222/1013 ,  C08F2220/1858 ,  C08F2220/325 ,  C08L101/02

摘要： A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R1, R2 and R3 are the same or different and each represents hydrogen atom or C1-4 alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.

摘要翻译： 含有具有式（I）表示的基团的聚合物的伤口覆盖剂（其中R 1，R 2和R 3相同或不同，各自表示氢原子或C 1-4烷基， m为2〜4的整数）; 含有该制剂的伤口覆盖材料; 以及伤口愈合方法，其包括用伤口覆盖材料覆盖受试者的伤口以保护伤口的步骤。

公开(公告)号：US20060217276A1

公开(公告)日：2006-09-28

申请号：US11423096

申请日：2006-06-08

申请人： Motohiro Mitani ,  Ryota Ando ,  Hirofumi Irie ,  Ken Suzuki ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

发明人： Motohiro Mitani ,  Ryota Ando ,  Hirofumi Irie ,  Ken Suzuki ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

IPC分类号： C11D3/00

CPC分类号： C11D3/046 ,  A61L12/142 ,  C11D3/0078 ,  C11D3/3784 ,  C11D3/48

摘要： Contact lens wetting solutions for reducing friction between the contact lens and ocular tissues, and maintaining such effect for a long time, are disclosed. The wetting solution is composed only of a particular ratio of a lubricant composed of copolymer (A) obtained by polymerizing a monomer composition comprising 2-(meth)acryloyloxyethyl phosphorylcholine and alkyl(meth)acrylate, a buffer, an inorganic chloride, a preservative, a chelating agent, and water. The copolymer (A) has a weight average molecular weight of 100,000 to 1,000,000, and satisfies the formula 80≦N×R≦240, provided that 4≦N≦18 and 10%≦R≦60%, wherein N stands for the carbon number of the alkyl group in monomer Y constituting copolymer (A), and R stands for a molar fraction of the unit derived from monomer Y with respect to the sum of the units derived from monomers X and Y.

摘要翻译： 公开了用于减少隐形眼镜与眼组织之间的摩擦并且长时间保持这种效果的隐形眼镜润湿溶液。 润湿溶液仅由通过聚合包含2-（甲基）丙烯酰氧基乙基磷酸胆碱和（甲基）丙烯酸烷基酯的单体组合物获得的共聚物（A），缓冲剂，无机氯化物，防腐剂， 螯合剂和水。 共聚物（A）的重均分子量为100,000〜1,000,000，满足公式80 <= N×R <= 240，条件是4≤N≤18且10％≤R≤60％，其中N 表示构成共聚物（A）的单体Y中的烷基的碳数，R表示来自单体Y的单元的摩尔分数相对于衍生自单体X和Y的单元的总和。

公开(公告)号：US5629361A

公开(公告)日：1997-05-13

申请号：US455205

申请日：1995-05-31

申请人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Yasukazu Saimi

发明人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Yasukazu Saimi

IPC分类号： A61K6/00 ,  A61K6/083 ,  C08F2/26 ,  C08F220/12 ,  C08F228/02 ,  C08K5/09 ,  C08K5/17

CPC分类号： C08F228/02 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0094 ,  A61K6/083 ,  C08F2/26 ,  C08F220/12

摘要： An emulsion of a polymer, in which the polymer comprises (a) a recurring unit derived from a (meth)acrylate and (b) a recurring unit derived from a vinyl compound having a group of --SO.sub.3 R in which R is a hydrogen atom, an alkali metal atom or ammonium ion. The emulsion forms a film on an adherend to decrease the infiltration into the adherend, exhibits an adhesion force to a hydroxyapatite structure, a cement, a metal or a mineral when it is applied thereto to form a film by only drying around room temperature without washing it with water, and exhibits excellent affinity to a radical-polymerizable acrylic resin composition.

摘要翻译： 聚合物的乳液，其中聚合物包含（a）衍生自（甲基）丙烯酸酯的重复单元和（b）衍生自具有-SO 3 R基团的乙烯基化合物的重复单元，其中R是氢原子， 碱金属原子或铵离子。 乳液在被粘物上形成膜以减少渗透到被粘物中，当施加到被粘附物上时，其表现出对羟基磷灰石结构，水泥，金属或矿​​物质的附着力，仅在室温下干燥而不洗涤 并且对自由基聚合性丙烯酸树脂组合物表现出极好的亲和力。

公开(公告)号：US5554669A

公开(公告)日：1996-09-10

申请号：US327414

申请日：1994-10-21

申请人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Yasukazu Saimi

发明人： Nobuo Nakabayashi ,  Kazuhiko Ishihara ,  Yasukazu Saimi

IPC分类号： A61K6/00 ,  A61K6/083 ,  C08F2/26 ,  C08F220/12 ,  C08F228/02 ,  C08L33/08 ,  C08L33/10

CPC分类号： C08F228/02 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/0094 ,  A61K6/083 ,  C08F2/26 ,  C08F220/12

摘要： An emulsion of a polymer, in which the polymer comprises (a) a recurring unit derived from a (meth)acrylate and (b) a recurring unit derived from a vinyl compound having a group of --SO.sub.3 R in which R is a hydrogen atom, an alkali metal atom or ammonium ion. The emulsion forms a film on an adherend to decrease the infiltration into the adherend, exhibits an adhesion force to a hydroxyapatite structure, a cement, a metal or a mineral when it is applied thereto to form a film by only drying around room temperature without washing it with water, and exhibits excellent affinity to a radical-polymerizable acrylic resin composition.

摘要翻译： 聚合物的乳液，其中聚合物包含（a）衍生自（甲基）丙烯酸酯的重复单元和（b）衍生自具有-SO 3 R基团的乙烯基化合物的重复单元，其中R是氢原子， 碱金属原子或铵离子。 乳液在被粘物上形成膜以减少渗透到被粘物中，当施加到被粘附物上时，其表现出对羟基磷灰石结构，水泥，金属或矿​​物质的附着力，仅在室温下干燥而不洗涤 并且对自由基聚合性丙烯酸树脂组合物表现出极好的亲和力。

公开(公告)号：US06204324B1

公开(公告)日：2001-03-20

申请号：US08750102

申请日：1996-12-02

申请人： Kenshiro Shuto ,  Kazuo Matsuyama ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

发明人： Kenshiro Shuto ,  Kazuo Matsuyama ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

IPC分类号： C08L4300

CPC分类号： C08F30/02 ,  C08F6/003 ,  C08F6/06

摘要： A method for producing an aqueous solution of a polymer having a phosphorylcholine group in which a polymerizable composition containing a polymerizable monomer having the phosphorylcholine group represented by the formula (1) is polymerized in the presence of a non-metal polymerization initiator soluble in a water-containing medium, to obtain a crude polymer aqueous solution, and the crude polymer aqueous solution is purified with a separation membrane, and an aqueous solution of the polymer having the phosphorylcholine group obtained by the method and having not more than 2000 ppm of impurities. (X: a divalent organic residue, Y: an alkyleneoxy group having C1 to 6, Z: H, R5—O—CO—(R5: an alkyl group of C1 to 10), R1:H, CH3, R2, R3, R4: H, a hydrocarbon group or a hydroxy substituted hydrocarbon group of C1 to 6, m; 0 or 1)

摘要翻译： 一种具有磷酸胆碱基团的聚合物的水溶液的制备方法，其中含有具有式（1）表示的磷酸胆碱基的可聚合单体的可聚合组合物在可溶于水的非金属聚合引发剂存在下聚合 以获得粗聚合物水溶液，并且用分离膜纯化粗聚合物水溶液，并且通过该方法获得具有磷酸胆碱基的聚合物的水溶液，并且具有不超过2000ppm的杂质。 （X：二价有机残基，Y：具有C1〜6的亚烷基氧基，Z：H，R5-O-CO-（R5：C1〜10的烷基），R1：H，CH3，R2，R3， R4：H，C 1-6的烃基或羟基取代的烃基，m; 0或1）

公开(公告)号：US06258371B1

公开(公告)日：2001-07-10

申请号：US09054389

申请日：1998-04-03

申请人： Edouard Koulik ,  Larik Vincent ,  Patrick Cahalan ,  Eric Fogt ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

发明人： Edouard Koulik ,  Larik Vincent ,  Patrick Cahalan ,  Eric Fogt ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

IPC分类号： A61F1300

CPC分类号： A61L33/0047 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  C08L33/14

摘要： A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.

摘要翻译： 通过使用共聚物涂层制造生物相容性医疗用品，优选血液相容性医疗用品的方法。 使用具有官能团（伯氨基）的甲基丙烯酸酯或丙烯酸酯单体合成用于随后连接肝素的共聚物涂层。 共聚物涂层的合成使用适当比例的疏水单体/亲水单体/官能单体进行，以优化共聚物在醇中的溶解度，其在水中的不溶性（肝素偶联之前和之后），肝素偶联效力和 肝素生物活性。 一旦制成共聚物涂层，医用制品被涂覆。 然后将涂层干燥并加入肝素。 以这种方式，本发明提供了制造生物相容性医疗用品，优选血液兼容医疗制品的方法。

公开(公告)号：US5368733A

公开(公告)日：1994-11-29

申请号：US133167

申请日：1993-10-13

申请人： Nobuo Nakabayashi ,  Kazuhiko Ishihara

发明人： Nobuo Nakabayashi ,  Kazuhiko Ishihara

IPC分类号： C08B15/06 ,  A61L33/08 ,  A61M1/18 ,  B01D67/00 ,  C08F251/02 ,  B01D69/08

CPC分类号： B01D67/0088 ,  A61L33/08 ,  C08F251/02

摘要： A water-soluble cellulose derivative which is obtained by subjecting a water-soluble cellulose to graft polymerization with 2-methacryloyloxyethyl phosphorylcholine and has a structural unit of the following formula (I): ##STR1## wherein n is an integer of 1-100, as well as a biocompatible material containing the water-soluble cellulose derivative as an effective component thereof. The water-soluble cellulose derivative having such specific structural unit is furnished with both of biocompatibility and affinity to cellulose and is thus utilizable as a biocompatible material, for example for hemocatharsis.

摘要翻译： PCT No.PCT / JP93 / 00177 Sec。 371日期：1993年10月13日 102（e）日期1993年10月13日PCT提交1993年2月12日PCT公布。 公开号WO93 / 16117 日本1988年8月19日。一种水溶性纤维素衍生物，其通过使水溶性纤维素与2-甲基丙烯酰氧基乙基磷酰胆碱进行接枝聚合而获得，并具有下式（I）的结构单元：其中n为 1-100的整数，以及含有水溶性纤维素衍生物作为其有效成分的生物相容性材料。 具有这种特定结构单元的水溶性纤维素衍生物具有生物相容性和对纤维素的亲和力，因此可用作生物相容性材料，例如用于血液渗透。

公开(公告)号：US06270788B1

公开(公告)日：2001-08-07

申请号：US09411405

申请日：1999-10-04

申请人： Edouard Koulik ,  Larik Vincent ,  Patrick Cahalan ,  Eric Fogt ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

发明人： Edouard Koulik ,  Larik Vincent ,  Patrick Cahalan ,  Eric Fogt ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

IPC分类号： A61F1300

CPC分类号： A61L33/0047 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0029 ,  C08L33/14

摘要： A method for making a biocompatible medical article, and preferably, a blood compatible medical article, through the use of a copolymer coating. The copolymer coating is synthesized using methacrylate or acrylate monomers with a functional group (primary amino group) for subsequent attachment of heparin. Synthesis of the copolymer coating is carried out using the proper proportion of hydrophobic monomer/hydrophilic monomer/functional monomer in order to optimize the solubility of the copolymer in alcohol, its insolubility in water (before and after heparin coupling), the heparin coupling efficacy and heparin bioactivity. Once the copolymer coating is fashioned, a medical article is coated with it. The coating is thereafter dried and heparin attached. In such a manner the present invention provides for a method for making a biocompatible medical article, and preferably, a blood compatible medical article.

摘要翻译： 通过使用共聚物涂层制造生物相容性医疗用品，优选血液相容性医疗用品的方法。 使用具有官能团（伯氨基）的甲基丙烯酸酯或丙烯酸酯单体合成用于随后连接肝素的共聚物涂层。 共聚物涂层的合成使用适当比例的疏水单体/亲水单体/官能单体进行，以优化共聚物在醇中的溶解度，其在水中的不溶性（肝素偶联之前和之后），肝素偶联效力和 肝素生物活性。 一旦制成共聚物涂层，医用制品被涂覆。 然后将涂层干燥并加入肝素。 以这种方式，本发明提供了制造生物相容性医疗用品，优选血液兼容医疗制品的方法。