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    Method for producing aqueous solution of polymer having phosphorylcholine groups
    1.
    发明授权
    Method for producing aqueous solution of polymer having phosphorylcholine groups 失效
    制备具有磷酸胆碱基团的聚合物水溶液的方法

    公开(公告)号：US06204324B1

    公开(公告)日：2001-03-20

    申请号：US08750102

    申请日：1996-12-02

    申请人： Kenshiro Shuto ,  Kazuo Matsuyama ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

    发明人： Kenshiro Shuto ,  Kazuo Matsuyama ,  Nobuo Nakabayashi ,  Kazuhiko Ishihara

    IPC分类号： C08L4300

    CPC分类号： C08F30/02 ,  C08F6/003 ,  C08F6/06

    摘要： A method for producing an aqueous solution of a polymer having a phosphorylcholine group in which a polymerizable composition containing a polymerizable monomer having the phosphorylcholine group represented by the formula (1) is polymerized in the presence of a non-metal polymerization initiator soluble in a water-containing medium, to obtain a crude polymer aqueous solution, and the crude polymer aqueous solution is purified with a separation membrane, and an aqueous solution of the polymer having the phosphorylcholine group obtained by the method and having not more than 2000 ppm of impurities. (X: a divalent organic residue, Y: an alkyleneoxy group having C1 to 6, Z: H, R5—O—CO—(R5: an alkyl group of C1 to 10), R1:H, CH3, R2, R3, R4: H, a hydrocarbon group or a hydroxy substituted hydrocarbon group of C1 to 6, m; 0 or 1)

    摘要翻译： 一种具有磷酸胆碱基团的聚合物的水溶液的制备方法，其中含有具有式（1）表示的磷酸胆碱基的可聚合单体的可聚合组合物在可溶于水的非金属聚合引发剂存在下聚合 以获得粗聚合物水溶液，并且用分离膜纯化粗聚合物水溶液，并且通过该方法获得具有磷酸胆碱基的聚合物的水溶液，并且具有不超过2000ppm的杂质。 （X：二价有机残基，Y：具有C1〜6的亚烷基氧基，Z：H，R5-O-CO-（R5：C1〜10的烷基），R1：H，CH3，R2，R3， R4：H，C 1-6的烃基或羟基取代的烃基，m; 0或1）

    Medical materials and process for producing the same
    3.
    发明授权
    Medical materials and process for producing the same 有权
    医疗材料和生产过程相同

    公开(公告)号：US06828028B1

    公开(公告)日：2004-12-07

    申请号：US10048367

    申请日：2002-01-25

    申请人： Hiroki Fukui ,  Ken Suzuki ,  Kenshiro Shuto ,  Nobuyuki Yamamoto ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

    发明人： Hiroki Fukui ,  Ken Suzuki ,  Kenshiro Shuto ,  Nobuyuki Yamamoto ,  Kazuhiko Ishihara ,  Nobuo Nakabayashi

    IPC分类号： B32B2738

    CPC分类号： A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L33/06 ,  Y10T428/31511 ,  Y10T428/31515

    摘要： A medical material having a surface which is safe and excellent in stability with the lapse of time and has a high durability as needed in establishing a long-lasting surface lubricity in a wet state and an excellent compatibility with blood, and a method for producing the same. These materials are obtained by forming a coating layer with a coating material containing a polymeric substance (A) having a heterocyclic group represented by the formula (1) on at least a part of a surface of a medical material base, and then ring-opening the heterocyclic group remaining in the coating layer by a nucleophilic compound (N): wherein X represents O, NH or S; and R1 represents H or CH3.

    摘要翻译： 一种医用材料，其具有安全性和稳定性优异的时间，并且在建立湿状态下的持久的表面润滑性和与血液的优异的相容性方面需要时具有高的耐久性，以及用于制备 相同。 这些材料通过在包含医药材料基材的表面的至少一部分上的含有式（1）表示的具有杂环基的聚合物质（A）的涂布材料形成涂层而得到，然后开环 通过亲核化合物（N）保留在涂层中的杂环基：其中X表示O，NH或S; 且R 1表示H或CH 3。

    Nonspecific hybridization inhibitors, clinical examination reagents and clinical examination method
    6.
    发明授权
    Nonspecific hybridization inhibitors, clinical examination reagents and clinical examination method 有权
    非特异性杂交抑制剂，临床检查试剂和临床检查方法

    公开(公告)号：US08252531B2

    公开(公告)日：2012-08-28

    申请号：US10476069

    申请日：2002-04-25

    申请人： Shujiro Sakaki ,  Kenshiro Shuto ,  Mamoru Tsuchida ,  Yoshihiro Ashihara ,  Mitsuo Isomura

    发明人： Shujiro Sakaki ,  Kenshiro Shuto ,  Mamoru Tsuchida ,  Yoshihiro Ashihara ,  Mitsuo Isomura

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6832

    摘要： The present invention relates to an inhibitor capable of increasing accuracy of the reaction in hybridization, and inhibiting nonspecific hybridization, a clinical diagnostic reagent, and a method of clinical analysis whereby nonspecific hybridization in clinical analysis is inhibited, and a target nucleic substance is detected easily with high accuracy. The inhibitor and the clinical diagnostic reagent contains polymer (H) having a nonspecific hybridization inhibitory action. The polymer has in its molecule at least one of carboxyl and sulfone groups, and phosphorylcholine-like groups, and has a weight average molecular weight of 1000 to 5000000. The method of clinical analysis includes contacting a sample with a test agent capable of hybridizing with a specific nucleic substance in the presence of the inhibitor.

    摘要翻译： 本发明涉及能够提高杂交反应精度，抑制非特异性杂交的抑制剂，临床诊断试剂和临床分析方法，临床分析中的非特异性杂交被抑制，容易检测到靶核酸 准确度高。 抑制剂和临床诊断试剂含有具有非特异性杂交抑制作用的聚合物（H）。 聚合物在其分子中具有羧基和砜基中的至少一个和磷酸胆碱样基团，并且具有1000至5000000的重均分子量。临床分析方法包括使样品与能够与 在抑制剂存在下的特定核酸物质。

    COSMETIC PRODUCT, NANOPARTICLES FOR COSMETICS, AND POWDER FOR COSMETICS
    7.
    发明申请
    COSMETIC PRODUCT, NANOPARTICLES FOR COSMETICS, AND POWDER FOR COSMETICS 审中-公开
    化妆品，化妆品用纳米脂和化妆品粉末

    公开(公告)号：US20100040697A1

    公开(公告)日：2010-02-18

    申请号：US12581474

    申请日：2009-10-19

    申请人： Hiroki Fukui ,  Yoshimi Sekine ,  Daisuke Kayaba ,  Eui-chul Kang ,  Atsuhiko Ogura ,  Kenshiro Shuto

    发明人： Hiroki Fukui ,  Yoshimi Sekine ,  Daisuke Kayaba ,  Eui-chul Kang ,  Atsuhiko Ogura ,  Kenshiro Shuto

    IPC分类号： A61K9/50 ,  A61K31/74

    CPC分类号： A61K8/8152 ,  A61K8/0241 ,  A61K2800/413 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q1/02 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/00 ,  A61Q19/00 ,  B82Y5/00

    摘要： The invention provides a cosmetic product which has a good texture and allows full expression of the inherent functions of ceramide as an intercellular lipid, such as skin barrier function and hair protection effect, as well as nanoparticles for cosmetics and powder for cosmetics which may be used in the above cosmetic product, exhibit good skin barrier function and hair protection effect, and are easy to incorporate into the above cosmetic product. The cosmetic product, the nanoparticles, and the powder for cosmetics according to the present invention contain a polymer obtained by polymerization of a monomer material containing a glycerol (meth)acrylate monomer represented by the formula (1): (R1: —H, —CH3; R2: —(CH2)n-; n is an integer of 1 to 4).

    摘要翻译： 本发明提供了一种具有良好质地的化妆品，并且能够充分表达神经酰胺作为细胞间脂质的固有功能，例如皮肤屏障功能和毛发保护效果，以及可用于化妆品的化妆品和粉末的纳米颗粒 在上述化妆品中，具有良好的皮肤屏障功能和护发效果，并且容易并入上述化妆品中。 根据本发明的化妆品，纳米颗粒和化妆品粉末含有通过聚合由式（1）表示的甘油（甲基）丙烯酸酯单体的单体材料得到的聚合物：（R1：-H， - CH3; R2： - （CH2）n-; n为1〜4的整数）。

    Polymerized product of protein and process for producing it
    8.
    发明授权
    Polymerized product of protein and process for producing it 失效
    蛋白质聚合产物及其制备方法

    公开(公告)号：US5807942A

    公开(公告)日：1998-09-15

    申请号：US657557

    申请日：1996-06-04

    申请人： Shujiro Sakaki ,  Satoshi Yamada ,  Motohiro Mitani ,  Kenshiro Shuto ,  Yasumi Koinuma

    发明人： Shujiro Sakaki ,  Satoshi Yamada ,  Motohiro Mitani ,  Kenshiro Shuto ,  Yasumi Koinuma

    IPC分类号： C08H1/00 ,  C12N11/02 ,  C12N11/06 ,  C12N11/08

    CPC分类号： C08H1/00

    摘要： A polymerized product of protein, comprising a polymer of one or more protein-containing monomers represented by the general formula P.sub.r --�(Y).sub.k --(X).sub.m --R.sup.1 !.sub.n (1) wherein R.sup.1 represents a polymerizable group capable of causing a radical polymerization, P.sub.r denotes a protein residue, Y denotes a group formed from a functional group in said protein and the functional group R.sub.2 of the modifying agent given below, X denotes an organic divalent radical, k is zero or 1, m is zero or 1 and n is a numeral of 1 or higher, said protein-containing monomer being obtained by reacting a protein with a modifying agent represented by the general formula, R.sup.2 --(X).sub.m --R.sup.1 (2) wherein R.sub.2 represents a functional group capable of combining with a functional group of protein and R.sup.1, X and m are as given above.

    摘要翻译： 一种蛋白质的聚合物，其含有一种或多种由通式P - [（Y）k-（X）m -R 1] n（1）表示的含有蛋白质的单体的聚合物，其中R1表示可引起 自由基聚合，Pr表示蛋白质残基，Y表示由所述蛋白质中的官能团形成的基团和下述赋形剂的官能团R2，X表示有机二价基团，k表示0或1，m为零或 1和n为1以上的数，所述含蛋白质的单体通过使蛋白质与通式R2-（X）m -R1（2）表示的改性剂反应而得到，其中，R2表示具有官能团的官能团 与蛋白质官能团结合，R1，X和m如上所述。

    Agitation mixer and feed pipe structure
    9.
    发明授权
    Agitation mixer and feed pipe structure 有权
    搅拌搅拌机和进料管结构

    公开(公告)号：US07993052B2

    公开(公告)日：2011-08-09

    申请号：US11863634

    申请日：2007-09-28

    申请人： Nobuyuki Sakamoto ,  Kenshiro Shuto ,  Satoshi Yamada ,  Hirofumi Irie

    发明人： Nobuyuki Sakamoto ,  Kenshiro Shuto ,  Satoshi Yamada ,  Hirofumi Irie

    IPC分类号： B01F7/04

    CPC分类号： B01F7/164 ,  B01F15/0202 ,  B01F15/0265

    摘要： An agitation method for mixing a solution and a solvent to precipitate a solid substance from the solution. The method includes preparing an agitation mixer including an agitation vessel, an impeller rotated in the agitation vessel, and a feed pipe connected to the agitation vessel and having a multiple pipe structure including an outer pipe and an inner pipe arranged in the outer pipe. A shearing clearance is formed in the agitation vessel between the impeller and the feed pipe. The method further includes shearing the solution and the solvent by rotating the impeller to precipitate the solid substance while feeding the solution and the solvent into the shearing clearance from the outer pipe and the inner pipe.

    摘要翻译： 用于混合溶液和溶剂以从溶液中沉淀出固体物质的搅拌方法。 该方法包括制备包括搅拌容器，在搅拌容器中旋转的叶轮和连接到搅拌槽的进料管的搅拌混合器，并具有包括布置在外管中的外管和内管的多管结构。 在叶轮和进料管之间的搅拌容器中形成剪切间隙。 该方法还包括在将溶液和溶剂从外管和内管供给到剪切间隙中的同时旋转叶轮以沉淀固体物质来剪切溶液和溶剂。

    Disinfectant gel for hands
    10.
    发明授权
    Disinfectant gel for hands 有权
    消毒剂凝胶手

    公开(公告)号：US07824665B2

    公开(公告)日：2010-11-02

    申请号：US11533639

    申请日：2006-09-20

    申请人： Koji Miyamoto ,  Yoshimi Sekine ,  Hiroki Fukui ,  Kenshiro Shuto

    发明人： Koji Miyamoto ,  Yoshimi Sekine ,  Hiroki Fukui ,  Kenshiro Shuto

    IPC分类号： A61K8/81 ,  A61K8/73 ,  A01N25/00

    CPC分类号： A01N31/02 ,  A01N25/04 ,  A01N25/10 ,  A01N33/12 ,  A01N47/44 ,  A01N2300/00

    摘要： The invention provides a quick-drying disinfectant gel for hands that spreads well in rubbing into hands, spreads easily over the hands, forms no scum, and is not sticky before and after drying. The disinfectant gel for hands of the invention contains 0.01 to 2.0 wt % of a maleic anhydride polymer, 0.01 to 5.0 wt % of polysaccharides, 40 to 95 wt % of a lower alcohol, and water, with the total being 100 wt %.

    摘要翻译： 本发明提供了一种快速消毒的手糊凝胶，可以很好地涂抹在手中，易于手掌涂抹，不会形成浮渣，干燥前后不粘。 本发明的手用消毒剂凝胶含有0.01〜2.0重量％的马来酸酐聚合物，0.01〜5.0重量％的多糖，40〜95重量％的低级醇和水，总计为100重量％。