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公开(公告)号：US08067434B2
公开(公告)日：2011-11-29
申请号：US12082665
申请日：2008-04-11
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong-Liang Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译： 描述了在Ret上活性的化合物，以及使用这些化合物的方法。 还描述了使用X射线晶体学测定的Ret替代物的晶体结构。 使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。
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公开(公告)号：US07504509B2
公开(公告)日：2009-03-17
申请号：US11016350
申请日：2004-12-17
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译： 描述了在Ret上活性的化合物，以及使用这些化合物的方法。 还描述了使用X射线晶体学测定的Ret替代物的晶体结构。 使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。
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公开(公告)号：US20100324065A1
公开(公告)日：2010-12-23
申请号：US12082665
申请日：2008-04-11
申请人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Richard Artis , Ryan Bremer , Gaston Habets , Clarence R. Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： A61K31/497 , A61K31/437
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译： 描述了在Ret上活性的化合物，以及使用这些化合物的方法。 还描述了使用X射线晶体学测定的Ret替代物的晶体结构。 使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。
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公开(公告)号：US20070049615A1
公开(公告)日：2007-03-01
申请号：US11016350
申请日：2004-12-17
申请人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
发明人： Prabha Ibrahim , Dean Artis , Ryan Bremer , Gaston Habets , Clarence Hurt , Shumeye Mamo , Marika Nespi , Chao Zhang , Jiazhong Zhang , Yong Zhu , Rebecca Zuckerman , Heike Krupka , Abhinav Kumar , Brian West
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
摘要翻译： 描述了在Ret上活性的化合物，以及使用这些化合物的方法。 还描述了使用X射线晶体学测定的Ret替代物的晶体结构。 使用这种Ret替代晶体和结构信息可以例如用于鉴定分子支架和开发结合并调节Ret的配体，并用于基于已知配体鉴定改良的配体。
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公开(公告)号：US20050170431A1
公开(公告)日：2005-08-04
申请号：US10789818
申请日：2004-02-27
IPC分类号： C07K16/40 , C12N20060101 , C12N9/12 , G01N33/53 , G01N33/573
CPC分类号： G01N33/573 , C07K2299/00 , C12N9/1205 , G01N2333/9121 , G01N2500/00
摘要： A crystal structure of PYK2 is described that was determined by X-ray crystallography. The use of PYK2 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PYK2.
摘要翻译： 描述了通过X射线晶体学确定的PYK2的晶体结构。 例如，使用PYK2晶体和结构信息可以用于鉴定分子支架和开发结合和调节PYK2的配体。
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公开(公告)号：US09058210B2
公开(公告)日：2015-06-16
申请号：US12948599
申请日：2010-11-17
CPC分类号： H04L47/70 , G06F9/5011 , G06F9/505 , G06F17/30657 , G06F17/30864 , G06F2209/504 , H04L63/10 , H04L67/22 , Y02D10/22
摘要： Methods and systems to automatically respond to consider the weight of a request when responding to requests associated with resources are described. In one embodiment, an interface module may be configured to receive a request associated with consumer identifier and a resource. A calculator module may be configured to determine a weight of the request and a usage module configured to calculate, using a processor, a usage level associated with the consumer identifier, the usage level based on a usage history associated with the consumer identifier. An enforcer module may also be configured to respond to the request based on the usage level and the weight of the request. In one embodiment, the usage module may also be configured to update the usage level associated with the consumer identifier based on the weight of the request.
摘要翻译： 描述在响应与资源相关联的请求时自动响应的方法和系统来考虑请求的权重。 在一个实施例中，接口模块可以被配置为接收与消费者标识符和资源相关联的请求。 计算器模块可以被配置为确定请求的权重，并且使用模块被配置为基于与消费者标识符相关联的使用历史来使用处理器来计算与消费者标识符相关联的使用水平的使用水平。 执行者模块还可以被配置为基于请求的使用级别和权重来响应请求。 在一个实施例中，使用模块还可以被配置为基于请求的权重来更新与消费者标识符相关联的使用水平。
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公开(公告)号：US08621259B2
公开(公告)日：2013-12-31
申请号：US12986877
申请日：2011-01-07
申请人： James Lloyd , Faye Dai Hall , Michael Eynon , Abhinav Kumar
发明人： James Lloyd , Faye Dai Hall , Michael Eynon , Abhinav Kumar
IPC分类号： G06F11/00
CPC分类号： G06F11/3495 , G06F11/3447 , G06F11/3476 , G06F2201/87
摘要： A method to detect potential problems within a heterogeneous and diverse application environment. Operations data is received from a plurality of application servers within the application environment. The operations data pertains to operations performed at the plurality of application servers over a predetermined time interval. The operations data is aggregated. The aggregated data is compared to reference data, and a potential problem within the application environment is detected if the aggregated data deviates from the reference data in a predetermined manner.
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8.发明授权Flow tracing though diverse logical and physical application and infrastructure layers/dependencies 有权通过不同的逻辑和物理应用程序和基础架构层/依赖关系进行流程跟踪公开(公告)号：US09170917B2
公开(公告)日：2015-10-27
申请号：US13078677
申请日：2011-04-01
申请人： Abhinav Kumar , Bhaven Avalani
发明人： Abhinav Kumar , Bhaven Avalani
CPC分类号： G06F11/3688 , G06F8/70 , G06F11/3419 , G06F11/3452 , G06F11/3466 , G06F11/3476 , G06F2201/865 , G06F2201/87
摘要： In various exemplary embodiments, a system and a related method and a related computer-readable medium to perform the method, for tracking numerous software calls in an enterprise environment is provided. The method includes tracking, during a runtime operation of the enterprise environment, layers through which each of the software calls passes. The tracking includes logging each of a multitude of physical components involved in each of the software calls, annotating each of the physical components with associated metadata, logging each of a multitude of logical components involved in the software calls, annotating each of the logical components with associated metadata, and logging a reliance of each of the physical components and the logical components on other physical and logical components. A dependency map is generated indicating the layers tracked in each of the software calls.
摘要翻译： 在各种示例性实施例中，提供了一种用于执行该方法的系统和相关方法以及相关的计算机可读介质，用于跟踪企业环境中的许多软件调用。 该方法包括在企业环境的运行时操作期间跟踪每个软件呼叫通过的层。 跟踪包括记录每个软件调用中涉及的多个物理组件中的每一个，用关联的元数据注释每个物理组件，记录软件调用中涉及的大量逻辑组件中的每一个，用每个逻辑组件注释每个逻辑组件 关联的元数据，并记录每个物理组件和逻辑组件对其他物理和逻辑组件的依赖。 生成依赖关系图，指示在每个软件调用中跟踪的层。
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9.发明授权公开(公告)号：US08983966B2
公开(公告)日：2015-03-17
申请号：US13196516
申请日：2011-08-02
CPC分类号： G06F17/30321 , G06F11/3409 , G06F11/3452 , G06F11/3476 , G06F11/3495 , G06F17/30091 , G06F2201/805 , G06F2201/87 , G06F2201/875
摘要： In various embodiments, a system and related method for organizing transactional data from a diverse and heterogeneous application environment is disclosed. In an example embodiment, a system includes a file system and one or more daemon indexers in electrical communication with the file system. The file system is arranged as a non-relational and serverless file system to allow for cost-effectiveness with ready scalability. The file system is to receive, in substantially real-time, unsorted transactional data from a publishing module. The one or more daemon indexers are arranged to receive the unsorted transactional data from the file system, organize the unsorted transactional data by operational characteristics, and store the organized transactional data on the file system.
摘要翻译： 在各种实施例中，公开了一种用于从多样化和异构应用环境组织事务数据的系统和相关方法。 在示例实施例中，系统包括与文件系统电通信的文件系统和一个或多个守护进程索引器。 文件系统被布置为非关系和无服务器的文件系统，以便具有成本效益并具有可扩展性。 文件系统基本上实时地从发布模块接收未排序的事务数据。 一个或多个守护进程索引器被安排为从文件系统接收未排序的事务数据，通过操作特征组织未排序的事务数据，并将有组织的事务数据存储在文件系统上。
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公开(公告)号：US08407520B2
公开(公告)日：2013-03-26
申请号：US12766712
申请日：2010-04-23
申请人： Ronald Francis Murphy , Sastry K. Malladi , Weian Deng , Abhinav Kumar , Bhaven Avalani , Arun Rai Mony
发明人： Ronald Francis Murphy , Sastry K. Malladi , Weian Deng , Abhinav Kumar , Bhaven Avalani , Arun Rai Mony
IPC分类号： G06F11/00
CPC分类号： G06F11/0775 , G06F11/0709 , G06F11/0766 , G06F11/0769 , G06F11/0772 , H04L41/0681 , H04L41/5038
摘要： A computer-implemented system and method for the definition, creation, management, transmission, and monitoring of errors in a SOA environment. An example embodiment includes: defining a common standard error data structure; automatically generating a unique identifier (ID) for each new error data instance; allowing customization of error data structure through extensions; creation and management of error instances that conform to this structure; ability to group errors across various dimensions; introducing the concept of an error library, the error library including a plurality of localizable error bundles, each of the error bundles including a plurality of error data instances for a particular domain, along with the associated metadata; automatically creating runtime artifacts for each error; ability to transmit errors either as faults or as part of the normal response payload; automatic error metric collection based on various error categories, and finally, tooling to help manage error libraries and reporting errors.
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